Search Results - "Kambis, Tyler N"

Metabolites and Genes behind Cardiac Metabolic Remodeling in Mice with Type 1 Diabetes Mellitus by Kambis, Tyler N, Shahshahan, Hamid R, Mishra, Paras K

“…Metabolic remodeling is at the heart of diabetic cardiomyopathy. High glycemic fluctuations increase metabolic stress in the type 1 diabetes mellitus (T1DM)…”
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Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction by Kar, Sumit, Shahshahan, Hamid R, Kambis, Tyler N, Yadav, Santosh K, Li, Zhen, Lefer, David J, Mishra, Paras K

“…Patients with diabetes, a methionine-rich meat diet, or certain genetic polymorphisms show elevated levels of homocysteine (Hcy), which is strongly associated…”
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Transgenic Expression of miR-133a in the Diabetic Akita Heart Prevents Cardiac Remodeling and Cardiomyopathy by Kambis, Tyler N, Shahshahan, Hamid R, Kar, Sumit, Yadav, Santosh K, Mishra, Paras K

“…Advanced diabetes mellitus (DM) may have both insulin resistance and deficiency (double DM) that accelerates diabetic cardiomyopathy (DMCM), a cardiac muscle…”
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Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy by Kar, Sumit, Kambis, Tyler N, Mishra, Paras K

“…The death of cardiomyocytes is a precursor for the cascade of hypertrophic and fibrotic remodeling that leads to cardiomyopathy. In diabetes mellitus (DM), the…”
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miR‐133a Mitigates Ferroptosis by Attenuating Fatty Acid Metabolism in the Diabetic Heart by Kambis, Tyler N., Kar, Sumit, Mishra, Paras K.

“…Background/hypothesis of the study Myocardial lipid accumulation occurs prior to the development of cardiac dysfunction in patients with diabetes mellitus…”
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Genome Editing and Diabetic Cardiomyopathy by Kambis, Tyler N, Mishra, Paras K

“…Differential gene expression is associated with diabetic cardiomyopathy (DMCM) and culminates in adverse remodeling in the diabetic heart. Genome editing is a…”
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MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro by Yadav, Santosh K., Kambis, Tyler N., Kar, Sumit, Park, Song Y., Mishra, Paras K.

“…Providing a conducive microenvironment is critical to increase survival of transplanted stem cells in regenerative therapy. Hyperglycemia promotes stem cell…”
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Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease by Park, Song-Young, Pekas, Elizabeth J, Anderson, Cody P, Kambis, Tyler N, Mishra, Paras K, Schieber, Molly N, Wooden, TeSean K, Thompson, Jonathan R, Kim, Kyung Soo, Pipinos, Iraklis I

“…Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and muscle function in the lower limbs. A skeletal muscle myopathy…”
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Generating Ins2 +/- /miR-133aTg Mice to Model miRNA-Driven Cardioprotection of Human Diabetic Heart by Shahshahan, Hamid R, Kambis, Tyler N, Kar, Sumit, Yadav, Santosh K, Mishra, Paras K

“…Diabetes mellitus (DM) is caused either due to insulin deficiency (T1DM) or insulin resistance (T2DM). DM increases the risk of heart failure by diabetic…”
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Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic Cardiomyopathy by Kar, Sumit, Shahshahan, Hamid R, Hackfort, Bryan T, Yadav, Santosh K, Yadav, Roopali, Kambis, Tyler N, Lefer, David J, Mishra, Paras K

“…Obesity increases the risk of developing diabetes and subsequently, diabetic cardiomyopathy (DMCM). Reduced cardioprotective antioxidant hydrogen sulfide (H S)…”
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Regulating Polyamine Metabolism by miRNAs in Diabetic Cardiomyopathy by Kambis, Tyler N., Tofilau, Hadassha M. N., Gawargi, Flobater I., Chandra, Surabhi, Mishra, Paras K.

“…Purpose of Review Insulin is at the heart of diabetes mellitus (DM). DM alters cardiac metabolism causing cardiomyopathy, ultimately leading to heart failure…”
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Cardiac‐specific Overexpression of MiR‐133a Decreases Pyroptosis in Ins2+/− T1DM Mice Heart by Kambis, Tyler N., Yadav, Santosh K., Mishra, Paras K.

“…Increased pyroptosis (a caspase‐1‐dependent cell death) and decreased miR‐133a (the most abundant cardioprotective miRNA in the human heart) are documented in…”
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