Search Results - "Kambayashi, Jun‐ichi"

Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation by Fujimura, Hironobu, Altar, C Anthony, Chen, Ruoyan, Nakamura, Takashi, Nakahashi, Takeshi, Kambayashi, Jun-ichi, Sun, Bing, Tandon, Narendra N

“…Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays critical roles in the survival, growth, and maintenance of brain and…”
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Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor by Nakahashi, Takeshi, Fujimura, Hironobu, Altar, C.Anthony, Li, Jess, Kambayashi, Jun-ichi, Tandon, Narendra N, Sun, Bing

“…Brain-derived neurotrophic factor (BDNF) is an abundant neurotrophin in brain and peripheral nerves, where it affects neural development, survival and repair…”
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Increased platelet sensitivity to collagen in individuals resistant to low-dose aspirin by KAWASAKI, T, OZEKI, Y, IGAWA, T, KAMBAYASHI, J.-I

“…The purpose of this study was to assess individual differences in the pharmacological effects of acetylsalicylic acid (ASA) on bleeding time as measured by in…”
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Upregulation of Prostacyclin Synthesis-Related Gene Expression by Shear Stress in Vascular Endothelial Cells by Okahara, Kazuhiro, Sun, Bing, Kambayashi, Jun-ichi

“…Prostacyclin (prostaglandin I2, PGI2) has a variety of functions, including inhibition of smooth muscle cell proliferation, vasodilation, and antiplatelet…”
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Activation of the GP IIb-IIIa Complex Induced by Platelet Adhesion to Collagen Is Mediated by Both α2β1 Integrin and GP VI by Nakamura, Takashi, Kambayashi, Jun-ichi, Okuma, Minoru, Tandon, Narendra N.

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Vasopressin V2-Receptor blockade with tolvaptan in patients with chronic heart failure: Results from a double-blind, randomized trial by GHEORGHIADE, Mihai, NIAZI, Imran, OUYANG, John, CZERWIEC, Frank, KAMBAYASHI, Jun-Ichi, ZAMPINO, Manuela, ORLANDI, Cesare

“…In this study, we evaluated the effects of tolvaptan (OPC-41061), a novel, oral, nonpeptide vasopressin V2-receptor antagonist in patients with chronic heart…”
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Comparison of the Effects of Cilostazol and Milrinone on Intracellular cAMP Levels and Cellular Function in Platelets and Cardiac Cells by Cone, James, Wang, Sheng, Tandon, Narendra, Fong, Miranda, Sun, Bing, Sakurai, Kazushi, Yoshitake, Masuhiro, Kambayashi, Jun-ichi, Liu, Yongge

“…Cilostazol is a potent cyclic nucleotide phosphodiesterase (PDE) type 3 (PDE3) inhibitor that was recently approved by the Food and Drug Administration (FDA)…”
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Demonstration of Flow and Platelet Dependency in a Ferric Chloride-Induced Model of Thrombosis by Lockyer, Simon, Kambayashi, Jun-ichi

“…Further to characterize the processes involved in the FeCl3-induced thrombosis model, we determined the effect of aspirin, heparin, hirudin,…”
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Inhibition of Adenosine Uptake and Augmentation of Ischemia-Induced Increase of Interstitial Adenosine by Cilostazol, an Agent to Treat Intermittent Claudication by Liu, Yongge, Fong, Miranda, Cone, James, Wang, Sheng, Yoshitake, Masuhiro, Kambayashi, Jun-ichi

“…Cilostazol (Pletal), a quinolinone derivative with a cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitory activity, was recently approved by the Food…”
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New Mechanism of Action for Cilostazol: Interplay Between Adenosine and Cilostazol in Inhibiting Platelet Activation by Sun, Bing, Le, Sang N, Lin, Shihua, Fong, Miranda, Guertin, Maurice, Liu, Yongge, Tandon, Narendra N, Yoshitake, Masuhiro, Kambayashi, Jun-ichi

“…Cilostazol, a potent phosphodiesterase 3 inhibitor and anti-thrombotic agent, was recently shown to inhibit adenosine uptake into cardiac myocytes and vascular…”
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Interplay Between Inhibition of Adenosine Uptake and Phosphodiesterase Type 3 on Cardiac Function by Cilostazol, an Agent to Treat Intermittent Claudication by Wang, Sheng, Cone, James, Fong, Miranda, Yoshitake, Masuhiro, Kambayashi, Jun-ichi, Liu, Yongge

“…The authors have recently shown that cilostazol, a type 3 cyclic nucleotide phosphodiesterase (PDE3) inhibitor, has a much weaker positive inotropic effect…”
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Shear stress induces expression of CNP gene in human endothelial cells by Okahara, Kazuhiro, Kambayashi, Jun-ichi, Ohnishi, Tadashi, Fujiwara, Yoshiyuki, Kawasaki, Tomio, Monden, Morito

“…To elucidate the effect of blood flow on gene transcription of C-type natriuretic peptide (CNP), human umbilical vein endothelial cells were exposed to shear…”
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An anti‐platelet agent, OPC‐29030, inhibits translocation of 12‐lipoxygenase and 12‐hydroxyeicosatetraenoic acid production in human platelets by Ozeki, Yasushi, Nagamura, Yoshie, Ito, Hideki, Unemi, Fumiko, Kimura, Yukio, Igawa, Takehiro, Kambayashi, Jun‐ichi, Takahashi, Yoshitaka, Yoshimoto, Tanihiro

“…In human platelets, arachidonic acid is mainly metabolized by the two enzyme systems; cyclo‐oxygenase and 12‐lipoxygenase. Cyclo‐oxygenase produces…”
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Single embryonic stem cell-derived embryoid bodies for gene screening by Niimi, Masashi, Kim, Mu-Young, Tao, Lian, Liu, Hongmei, Wu, Xiaoyun, Kambayashi, Jun-ichi, Yoshitake, Masuhiro, Sun, Bing

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Shear stress down-regulates gene transcription and production of adrenomedullin in human aortic endothelial cells by Shinoki, Nobutoshi, Kawasaki, Tomio, Minamino, Naoto, Okahara, Kazuhiro, Ogawa, Atsuhiro, Ariyoshi, Hideo, Sakon, Masato, Kambayashi, Jun-ichi, Kangawa, Kenji, Monden, Morito

“…Vascular endothelial cells are potent modulators of vascular tone in response to shear stress. Levels of vasoactive peptides such as adrenomedullin (AM),…”
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Possible Involvement of m-Calpain in Vascular Smooth Muscle Cell Proliferation by Ariyoshi, Hideo, Okahara, Kazuhiro, Sakon, Masato, Kambayashi, Jun-ichi, Kawashima, Sei-ichi, Kawasaki, Tomio, Monden, Morito

“…Vascular smooth muscle cell (VSMC) proliferation still remains a poorly understood process, although it is believed to play a critical role in pathological…”
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Identification of μ-, m-calpains and calpastatin and capture of μ-calpain activation in endothelial cells by Fujitani, Kazumasa, Kambayashi, Jun-ichi, Sakon, Masato, Ohmi, Shinobu I., Kawashima, Sei-ichi, Yukawa, Masao, Yano, Yoshiko, Miyoshi, Hideyuki, Ikeda, Masataka, Shinoki, Nobutoshi, Monden, Morito

“…The presence of the calpain‐calpastatin system in human umbilical vein endothelial cells (HUVEC) was investigated by means of ion exchange chromatography,…”
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Fluid shear stress induces actin polymerization in human neutrophils by Okuyama, Masaki, Ohta, Yoshihiko, Kambayashi, Jun-ichi, Monden, Morito

“…We have previously reported that a physiological range of shear stress induces neutrophil homotypic aggregation mediated by lymphocyte function‐associated…”
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Cilostazol (pletal): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake by Liu, Y, Shakur, Y, Yoshitake, M, Kambayashi Ji, J

“…Cilostazol (Pletal), a quinolinone derivative, has been approved in the U.S. for the treatment of symptoms of intermittent claudication (IC) since 1999 and for…”
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Cell-penetrating inhibitors of calpain block both membrane fusion and filamin cleavage in chick embryonic myoblasts by Kwak, Kyu Bong, Kambayashi, Jun-ichi, Kang, Man Sik, Ha, Doo Bong, Chung, Chin Ha

“…Benzyloxycarbonyl(Z)-Leu-nLeu-H (calpeptin) and Z-Leu-Met-H, cell-penetrating inhibitors of calpain, were found to block myoblast fusion without any effect on…”
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