Search Results - "Kamath, Ajith V"

Structural Determinants for Inhibitor Specificity and Selectivity in PDE2A Using the Wheat Germ in Vitro Translation System by Iffland, André, Kohls, Darcy, Low, Simon, Luan, Jing, Zhang, Yan, Kothe, Michael, Cao, Qing, Kamath, Ajith V, Ding, Yuan-Hua, Ellenberger, Tom

“…Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac contractility, platelet aggregation, lipolysis,…”
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Differential Expression of SRY-Related HMG-Box Transcription Factor 2, Oligodendrocyte Lineage Transcription Factor 2, and Zinc Finger E‑Box Binding Homeobox 1 in Serum-Derived Extracellular Vesicles: Implications for Mithramycin Sensitivity and Targeted Therapy in High-Grade Glioma by Patnam, Sreekanth, Majumder, Biswanath, Joshi, Parth, Singh, Anula Divyash, Nagalla, Balakrishna, Kumar, Dilli, Biswas, Manjusha, Ranjan, Alok, Majumder, Pradip K., Rengan, Aravind Kumar, Kamath, Ajith V., Ray, Amitava, Manda, Sasidhar Venkata

“…Glioblastoma multiforme (GBM) is the most aggressive type of glioma and is often resistant to traditional therapies. Evidence suggests that glioma stem cells…”
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Kuragel: A biomimetic hydrogel scaffold designed to promote corneal regeneration by Agrawal, Parinita, Tiwari, Anil, Chowdhury, Suvro Kanti, Vohra, Mehak, Gour, Abha, Waghmare, Neha, Bhutani, Utkarsh, Kamalnath, S., Sangwan, Bharti, Rajput, Jyoti, Raj, Ritu, Rajendran, Nisha P., Kamath, Ajith V., Haddadin, Ramez, Chandru, Arun, Sangwan, Virender S., Bhowmick, Tuhin

“…Cornea-related injuries are the most common cause of blindness worldwide. Transplantation remains the primary approach for addressing corneal blindness, though…”
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The structure of XIAP BIR2: understanding the selectivity of the BIR domains by Lukacs, Christine, Belunis, Charles, Crowther, Robert, Danho, Waleed, Gao, Lin, Goggin, Barry, Janson, Cheryl A., Li, Shirley, Remiszewski, Stacy, Schutt, Andrew, Thakur, Manish K., Singh, Saroj K., Swaminathan, Srinivasan, Pandey, Rajat, Tyagi, Rajiv, Gosu, Ramachandraiah, Kamath, Ajith V., Kuglstatter, Andreas

“…XIAP, a member of the inhibitor of apoptosis family of proteins, is a critical regulator of apoptosis. Inhibition of the BIR domain–caspase interaction is a…”
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Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases by Board, Philip G., Coggan, Marjorie, Chelvanayagam, Gareth, Easteal, Simon, Jermiin, Lars S., Schulte, Gayle K., Danley, Dennis E., Hoth, Lise R., Griffor, Matthew C., Kamath, Ajith V., Rosner, Michele H., Chrunyk, Boris A., Perregaux, David E., Gabel, Christopher A., Geoghegan, Kieran F., Pandit, Jayvardhan

“…A new class of glutathione transferases has been discovered by analysis of the expressed sequence tag data base and sequence alignment. Glutathione…”
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High-throughput biochemical kinase selectivity assays: panel development and screening applications by Card, Amy, Caldwell, Chris, Min, Hyunsuk, Lokchander, Bina, Hualin Xi, Sciabola, Simone, Kamath, Ajith V, Clugston, Susan L, Tschantz, William R, Leyu Wang, Moshinsky, Deborah J

“…Kinases represent attractive targets for drug discovery. Eight small-molecule kinase inhibitors are currently marketed in the area of oncology, and numerous…”
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Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes by Clancy, J, Petitpas, J, Dib-Hajj, F, Yuan, W, Cronan, M, Kamath, A V, Bergeron, J, Retsema, J A

“…Several streptococcal strains had an uncharacterized mechanism of macrolide resistance that differed from those that had been reported previously in the…”
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Specificity Determinants of Human Cathepsin S Revealed by Crystal Structures of Complexes by Pauly, Thomas A, Sulea, Traian, Ammirati, Mark, Sivaraman, J, Danley, Dennis E, Griffor, Matthew C, Kamath, Ajith V, Wang, I.-K, Laird, Ellen R, Seddon, Andrew P, Ménard, Robert, Cygler, Miroslaw, Rath, Virginia L

“…Cathepsin S, a lysosomal cysteine protease of the papain superfamily, has been implicated in the preparation of MHC class II αβ-heterodimers for antigen…”
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Expression, purification and characterization of the human membrane transporter protein OATP2B1 from Sf9 insect cells by Tschantz, William R., Pfeifer, Nathan D., Meade, Caryl Lane, Wang, Leyu, Lanzetti, Anthony, Kamath, Ajith V., Berlioz-Seux, Francoise, Hashim, Muhammed F.

“…OATP2B1 is an important member of the organic anion transporting polypeptides (OATP) family and is implicated in the intestinal and hepatic disposition of…”
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Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors by Letavic, Michael A., Axt, Matt Z., Barberia, John T., Carty, Thomas J., Danley, Dennis E., Geoghegan, Kieran F., Halim, Nadia S., Hoth, Lise R., Kamath, Ajith V., Laird, Ellen R., Lopresti-Morrow, Lori L., McClure, Kim F., Mitchell, Peter G., Natarajan, Vijayalakshmi, Noe, Mark C., Pandit, Jayvardhan, Reeves, Lisa, Schulte, Gayle K., Snow, Sheri L., Sweeney, Francis J., Tan, Douglas H., Yu, Chul H.

“…A series of novel, selective TNF-α converting enzyme inhibitors based on 4-hydroxy and 5-hydroxy pipecolate hydroxamic acid scaffolds is described. The potency…”
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A new chemical tool for exploring the physiological function of the PDE2 isozyme by Chambers, Robert J., Abrams, Kristin, Garceau, Norman Y., Kamath, Ajith V., Manley, Christopher M., Lilley, Susan C., Otte, Douglas A., Scott, Dennis O., Sheils, Alissa L., Tess, David A., Vellekoop, A. Samuel, Zhang, Yan, Lam, Kelvin T.

“…Oxindole ( 2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in…”
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Formation in Vitro of Hybrid Dimers of H463F and Y74F Mutant Escherichia coli Tryptophan Indole-lyase Rescues Activity with l-Tryptophan by Phillips, Robert S, Johnson, Nancy, Kamath, Ajith V

“…Y74F and H463F mutant forms of Escherichia coli tryptophan indole-lyase (Trpase) have been prepared. These mutant proteins have very low activity with l-Trp as…”
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Identification of Allosteric PIF-Pocket Ligands for PDK1 using NMR-Based Fragment Screening and ¹H-¹⁵N TROSY Experiments by Stockman, Brian J, Kothe, Michael, Kohls, Darcy, Weibley, Laura, Connolly, Brendan J, Sheils, Alissa L, Cao, Qing, Cheng, Alan C, Yang, Lily, Kamath, Ajith V, Ding, Yuan-Hua, Charlton, Maura E

“…Aberrant activation of the phosphoinositide 3-kinase pathway because of genetic mutations of essential signalling proteins has been associated with human…”
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Cloning and Functional Characterization of an NAD+-Dependent DNA Ligase from Staphylococcus aureus by Kaczmarek, F S, Zaniewski, R P, Gootz, T D, Danley, D E, Mansour, M N, Griffor, M, Kamath, A V, Cronan, M, Mueller, J, Sun, D, Martin, P K, Benton, B, McDowell, L, Biek, D, Schmid, M B

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor by Hoth, Lise R., Tan, Douglas H., Wang, Ing-Kae, Wengender, Paul A., Thompson, Michelle A., Kamath, Ajith V., Geoghegan, Kieran F.

“…The membrane-anchored metalloproteinase ADAM17 (TNF-α converting enzyme; TACE; EC 3.4.24.86) continues to be an attractive drug target in inflammatory diseases…”
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A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function by Chambers, Robert J., Abrams, Kristin, Castleberry, Tessa A., Cheng, John B., Fisher, Douglas A., Kamath, Ajith V., Marfat, Anthony, Nettleton, David O., Pillar, Joann D., Salter, Eben D., Sheils, Alissa L., Shirley, John T., Turner, Claudia R., Umland, John P., Lam, Kelvin T.

“…Nicotinamide ( 2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis…”
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Roles of the tnaC-tnaA spacer region and Rho factor in regulating expression of the tryptophanase operon of Proteus vulgaris by Kamath, A V, Yanofsky, C

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Site-directed alteration of the active-site residues of histidine decarboxylase from Clostridium perfringens by Van Poelje, Paul D, Kamath, Ajith V, Snell, Esmond E

“…To clarify the mechanism of biogenesis and catalysis by the pyruvoyl-dependent histidine decarboxylase (HisDCase) from Clostridium perfringens, 12 mutant genes…”
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Spontaneous alpha-N-6-phosphogluconoylation of a "His tag" in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins by Geoghegan, K F, Dixon, H B, Rosner, P J, Hoth, L R, Lanzetti, A J, Borzilleri, K A, Marr, E S, Pezzullo, L H, Martin, L B, LeMotte, P K, McColl, A S, Kamath, A V, Stroh, J G

“…Several proteins expressed in Escherichia coli with the N-terminus Gly-Ser-Ser-[His]6- consisted partly (up to 20%) of material with 178 Da of excess mass,…”
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Identification of Allosteric PIF‐Pocket Ligands for PDK1 using NMR‐Based Fragment Screening and 1 H‐ 15 N TROSY Experiments by Stockman, Brian J., Kothe, Michael, Kohls, Darcy, Weibley, Laura, Connolly, Brendan J., Sheils, Alissa L., Cao, Qing, Cheng, Alan C., Yang, Lily, Kamath, Ajith V., Ding, Yuan‐Hua, Charlton, Maura E.

“…Aberrant activation of the phosphoinositide 3‐kinase pathway because of genetic mutations of essential signalling proteins has been associated with human…”
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