Three‐dimensional models of the segmented human fetal brain generated by magnetic resonance imaging

Recent advances in imaging technology have enabled us to obtain more detailed images of the human fetus in a nondestructive and noninvasive manner. Through detailed images, elaborate three‐dimensional (3D) models of the developing brain can be reconstructed. The segmentation of the developing brain...

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Bibliographic Details
Published in:	Congenital anomalies Vol. 58; no. 2; pp. 48 - 55
Main Authors:	Yamaguchi, Yutaka, Miyazaki, Reina, Kamatani, Mikako, Uwabe, Chigako, Makishima, Haruyuki, Nagai, Momoko, Katsube, Motoki, Yamamoto, Akira, Imai, Hirohiko, Kose, Katsumi, Togashi, Kaori, Yamada, Shigehito
Format:	Journal Article
Language:	English
Published:	Australia Wiley Subscription Services, Inc 01-03-2018
Subjects:	3D segmentation Algorithms Brain Brain - anatomy & histology Brain - diagnostic imaging brain development Embryos Fetus - anatomy & histology Fetus - diagnostic imaging Fetuses Grain boundaries human embryo human fetus Humans Image processing Image Processing, Computer-Assisted - methods Image reconstruction Image segmentation Imaging, Three-Dimensional - instrumentation Imaging, Three-Dimensional - methods Kyoto Collection Magnetic resonance imaging Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Models, Anatomic Morphology Neuroimaging NMR Nuclear magnetic resonance Organ Size Physical characteristics Resonance Three dimensional models brain development 3D segmentation human fetus human embryo Kyoto Collection
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Summary:	Recent advances in imaging technology have enabled us to obtain more detailed images of the human fetus in a nondestructive and noninvasive manner. Through detailed images, elaborate three‐dimensional (3D) models of the developing brain can be reconstructed. The segmentation of the developing brain has been determined by serial sections. Therefore, in this study, we attempted to develop a 3D model of the fetal brain using magnetic resonance image (MRI). MR images from 19 specimens (11 embryonic specimens and eight fetal specimens from 5.2 to 225 mm in crown rump length) were used to reconstruct 3D models of regionalized developing brains. From this analysis, we succeeded in registering a maximum of nine landmarks on MR images and reconstructing 19 sequential models of the regionalized developing brain. To confirm the validity of the landmarks, we also compared our results with three serial sections from the Kyoto Collection; the same morphological characteristics were observed on both serial sections and MRI. The morphological minutiae could be found on MR images, and regionalized models of the developing brain could be reconstructed. These results will be useful for clinical diagnosis of living fetuses in utero.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0914-3505 1741-4520
DOI:	10.1111/cga.12229