Search Results - "Kamata, Mika"

In vivo imaging with two-photon microscopy to assess the tumor-selective binding of an anti-CD137 switch antibody by Kaneko, Chisato, Tsutsui, Haruka, Ozeki, Kazuhisa, Honda, Masaki, Haraya, Kenta, Narita, Yoshinori, Kamata-Sakurai, Mika, Kikuta, Junichi, Tabo, Mitsuyasu, Ishii, Masaru

“…STA551, a novel anti-CD137 switch antibody, binds to CD137 in an extracellular ATP concentration-dependent manner. Although STA551 is assumed to show higher…”
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In vivo validation of the switch antibody concept: SPECT/CT imaging of the anti-CD137 switch antibody Sta-MB shows high uptake in tumors but low uptake in normal organs in human CD137 knock-in mice by Sugyo, Aya, Tsuji, Atsushi B, Sudo, Hitomi, Narita, Yoshinori, Taniguchi, Kenji, Nemoto, Takayuki, Isomura, Fumihisa, Awaya, Norihiro, Kamata-Sakurai, Mika, Higashi, Tatsuya

“…• Switch antibodies, Sta-MB and Sta-mIgG1, highly accumulated in tumors but not in the lymph nodes and spleen. • The conventional antibody Ure-MB showed high…”
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A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model by Kitazawa, Takehisa, Igawa, Tomoyuki, Sampei, Zenjiro, Muto, Atsushi, Kojima, Tetsuo, Soeda, Tetsuhiro, Yoshihashi, Kazutaka, Okuyama-Nishida, Yukiko, Saito, Hiroyuki, Tsunoda, Hiroyuki, Suzuki, Tsukasa, Adachi, Hideki, Miyazaki, Taro, Ishii, Shinya, Kamata-Sakurai, Mika, Iida, Takeo, Harada, Aya, Esaki, Keiko, Funaki, Miho, Moriyama, Chifumi, Tanaka, Eriko, Kikuchi, Yasufumi, Wakabayashi, Tetsuya, Wada, Manabu, Goto, Masaaki, Toyoda, Takeshi, Ueyama, Atsunori, Suzuki, Sachiyo, Haraya, Kenta, Tachibana, Tatsuhiko, Kawabe, Yoshiki, Shima, Midori, Yoshioka, Akira, Hattori, Kunihiro

“…Individuals with hemophilia A lack the coagulation factor FVIII and are treated with frequent intravenous injections of FVIII agents. However, many individuals…”
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Comparison of measurements of anti-PLA2R antibodies in Japanese patients with membranous nephropathy using in-house and commercial ELISA by Kaga, Hajime, Komatsuda, Atsushi, Yamamoto, Soh, Kikuchi, Tadashi, Kamata, Mika, Sato, Akiko, Odaka, Masafumi, Yokota, Shin-ichi, Takahashi, Naoto, Wakui, Hideki

“…Background The prevalence of antibodies against M-type anti-phospholipase A2 receptor (PLA2R) was reported to be ~ 70–80% in early studies on idiopathic…”
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578 Tumor selective immune responses of STA551, a novel anti-CD137 agonist antibody activated by extracellular ATP by Narita, Yoshinori, Kamata-Sakurai, Mika

“…BackgroundAgonistic antibodies targeting CD137 in clinic have failed due to severe hepatotoxicity, leading to the development of bispecific approaches that…”
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SAIL66, a next generation CLDN6-targeting T-cell engager, demonstrates potent antitumor efficacy through dual binding to CD3/CD137 by Kamikawa, Takayuki, Kimura, Naoki, Ishii, Shinya, Muraoka, Masaru, Kodama, Tatsushi, Taniguchi, Kenji, Yoshimoto, Moe, Miura-Okuda, Momoko, Uchikawa, Ryo, Kato, Chie, Shinozuka, Junko, Akai, Sho, Naoi, Sotaro, Tomioka, Nanami, Nagaya, Nishiki, Pang, Chai Ling, Garvita, Gupta, Feng, Shu, Shimada, Mei, Kamata-Sakurai, Mika, Aburatani, Hiroyuki, Kitazawa, Takehisa, Igawa, Tomoyuki

“…BackgroundOvarian cancer remains a formidable challenge in oncology, necessitating innovative therapeutic approaches. Claudin-6 (CLDN6), a member of the tight…”
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Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases by Sugiura, Daisuke, Aida, Satoshi, Denda‐Nagai, Kaori, Takeda, Kazuyoshi, Kamata‐Sakurai, Mika, Yagita, Hideo, Irimura, Tatsuro

“…The effects of MUC1 DNA vaccination on the orthotopic growth and liver metastasis of colon carcinoma cells were investigated in mice. Vaccination with MUC1 DNA…”
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1172 SAIL66, a next generation of T cell engager targeting CLDN6, potentiates efficacy by Kamikawa, Takayuki, Kimura, Naoki, Ishii, Shinya, Muraoka, Masaru, Taniguchi, Kenji, Uchikawa, Ryo, Yoshimoto, Moe, Okuda-Miura, Momoko, Akai, Sho, Kodama, Tatsushi, Sakumoto, Hirofumi, Kawai, Shigeto, Shimada, Mei, Kamata-Sakurai, Mika, Aburatani, Hiroyuki, Kitazawa, Takehisa, Igawa, Tomoyuki

“…BackgroundClaudin-6 (CLDN6), one of the over 20 known human CLDN family members, is upregulated in many solid tumors but shows minimal or no expression in…”
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A phase I dose escalation and cohort expansion study of T-cell redirecting bispecific antibody against Glypican 3 in patients with advanced solid tumors by Hashimoto, Kenji, Perera, Ayesh, Ogita, Yoshitaka, Nakamura, Mikiko, Ishiguro, Takahiro, Sano, Yuji, Kinoshita, Yasuko, Sakurai, Mika Kamata, Frings, Werner, Komatsu, Shun-ichiro, Kaneko, Akihisa, Ueda, Masamichi, Kishishita, Shohei, Gianella-Borradori, Athos

“…Abstract only…”
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An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors by Ishiguro, Takahiro, Sano, Yuji, Komatsu, Shun-Ichiro, Kamata-Sakurai, Mika, Kaneko, Akihisa, Kinoshita, Yasuko, Shiraiwa, Hirotake, Azuma, Yumiko, Tsunenari, Toshiaki, Kayukawa, Yoko, Sonobe, Yukiko, Ono, Natsuki, Sakata, Kiyoaki, Fujii, Toshihiko, Miyazaki, Yoko, Noguchi, Mizuho, Endo, Mika, Harada, Asako, Frings, Werner, Fujii, Etsuko, Nanba, Eitaro, Narita, Atsushi, Sakamoto, Akihisa, Wakabayashi, Tetsuya, Konishi, Hiroko, Segawa, Hiroaki, Igawa, Tomoyuki, Tsushima, Takashi, Mutoh, Hironori, Nishito, Yukari, Takahashi, Mina, Stewart, Lorraine, ElGabry, Ehab, Kawabe, Yoshiki, Ishigai, Masaki, Chiba, Shuichi, Aoki, Masahiro, Hattori, Kunihiro, Nezu, Junichi

“…Cancer care is being revolutionized by immunotherapies such as immune checkpoint inhibitors, engineered T cell transfer, and cell vaccines. The bispecific T…”
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Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974 by Shiraiwa, Hirotake, Narita, Atsushi, Kamata-Sakurai, Mika, Ishiguro, Takahiro, Sano, Yuji, Hironiwa, Naoka, Tsushima, Takashi, Segawa, Hiroaki, Tsunenari, Toshiaki, Ikeda, Yosuke, Kayukawa, Yoko, Noguchi, Mizuho, Wakabayashi, Tetsuya, Sakamoto, Akihisa, Konishi, Hiroko, Kuramochi, Taichi, Endo, Mika, Hattori, Kunihiro, Nezu, Junichi, Igawa, Tomoyuki

“…•History and methods of bispecific antibody generation with a common light chain.•Actual engineering of common light chain and other properties for bispecific…”
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Abstract 1851: Responses of a novel tumor selective anti-CD137 agonist antibody activated by elevated extracellular ATP in tumor microenvironment by Kamata-Sakurai, Mika, Narita, Yoshinori, Uchikawa, Ryo, Taniguchi, Kenji, Horikawa, Sayuri, Hamada, Koki, Hori, Yuji, Nemoto, Takayuki, Metsugi, Shoichi, Inatani, Michiyasu, Igawa, Tomoyuki

“…Background: CD137 (4-1BB) is a co-stimulatory molecule which exerts activation signals in multiple immune cell subsets. However, agonist antibodies targeting…”
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Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment by Mimoto, Futa, Tatsumi, Kanako, Shimizu, Shun, Kadono, Shojiro, Haraya, Kenta, Nagayasu, Miho, Suzuki, Yuki, Fujii, Etsuko, Kamimura, Masaki, Hayasaka, Akira, Kawauchi, Hiroki, Ohara, Kazuhiro, Matsushita, Masayuki, Baba, Takeshi, Susumu, Hiroaki, Sakashita, Takuya, Muraoka, Terushige, Aso, Kosuke, Katada, Hitoshi, Tanaka, Eriko, Nakagawa, Kenji, Hasegawa, Masami, Ayabe, Miho, Yamamoto, Tessai, Tanba, Shigero, Ishiguro, Takahiro, Kamikawa, Takayuki, Nambu, Takeru, Kibayashi, Tatsuya, Azuma, Yumiko, Tomii, Yasushi, Kato, Atsuhiko, Ozeki, Kazuhisa, Murao, Naoaki, Endo, Mika, Kikuta, Junichi, Kamata-Sakurai, Mika, Ishii, Masaru, Hattori, Kunihiro, Igawa, Tomoyuki

“…The extracellular adenosine triphosphate (ATP) concentration is highly elevated in the tumor microenvironment (TME) and remains tightly regulated in normal…”
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Abstract 5518: Single cell RNA sequencing revealed that the mechanism of the synergistic efficacy of STA551 and immune checkpoint inhibitor results from the induction of highly activated T cells in tumor by Uchikawa, Ryo, Takakuwa, Kazuya, Mikami, Hirofumi, Metsugi, Shoichi, Taniguchi, Kenji, Narita, Yoshinori, Kamata-Sakurai, Mika

“…Background: CD137 (4-1BB) is a co-stimulatory molecule which exerts activation signals in multiple immune cell subsets. However, agonist antibodies targeting…”
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Abstract 6715: CLDN6: Biological insight into therapeutic potency of SAIL66, a next generation of T-cell engager targeting CLDN6 by Kimura, Naoki, Taniguchi, Kenji, Kamikawa, Takayuki, Yoshimoto, Moe, Ishii, Shinya, Muraoka, Masaru, Shimada, Mei, Kamata-Sakurai, Mika, Kitazawa, Takehisa, Igawa, Tomoyuki

“…Background: Because of high recurrence rate, ovarian cancer continues to demand new treatments. Recently, we have developed a next-generation T-cell engager…”
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Macrophage C-type lectin on bone marrow–derived immature dendritic cells is involved in the internalization of glycosylated antigens by Denda-Nagai, Kaori, Kubota, Nobuyoshi, Tsuiji, Makoto, Kamata, Mika, Irimura, Tatsuro

“…Bone marrow–derived dendritic cells (DCs) were examined for the expression of the murine macrophage C-type lectin specific for galactose and…”
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Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer by Mikami, Hirofumi, Feng, Shu, Matsuda, Yutaka, Ishii, Shinya, Naoi, Sotaro, Azuma, Yumiko, Nagano, Hiroaki, Asanuma, Kentaro, Kayukawa, Yoko, Tsunenari, Toshiaki, Kamikawaji, Shogo, Iwabuchi, Ryutaro, Shinozuka, Junko, Yamazaki, Masaki, Kuroi, Haruka, Ho, Samantha Shu Wen, Gan, Siok Wan, Chichili, Priyanka, Pang, Chai Ling, Yeo, Chiew Ying, Shimizu, Shun, Hironiwa, Naoka, Kinoshita, Yasuko, Shimizu, Yuichiro, Sakamoto, Akihisa, Muraoka, Masaru, Takahashi, Noriyuki, Kawa, Tatsuya, Shiraiwa, Hirotake, Mimoto, Futa, Kashima, Kenji, Kamata-Sakurai, Mika, Ishikawa, Shumpei, Aburatani, Hiroyuki, Kitazawa, Takehisa, Igawa, Tomoyuki

“…Small-cell lung cancer (SCLC) is an aggressive cancer for which immune checkpoint inhibitors (ICI) have had only limited success. Bispecific T-cell engagers…”
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Abstract 1239: SAIL66, a next generation T cell engager targeting CLDN6, potentiates efficacy by binding to CD3/CD137 by Yoshimoto, Moe, Kimura, Naoki, Kamikawa, Takayuki, Ishii, Shinya, Muraoka, Masaru, Taniguchi, Kenji, Uchikawa, Ryo, Okuda-Miura, Momoko, Akai, Sho, Kodama, Tatsushi, Sakumoto, Hirofumi, Kawai, Shigeto, Shimada, Mei, Kamata-Sakurai, Mika, Aburatani, Hiroyuki, Kitazawa, Takehisa, Igawa, Tomoyuki

“…Background: Claudin-6 (CLDN6), one of over 20 known human CLDN family members, is upregulated in many solid tumors but shows minimal or no expression in…”
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Abstract DDT01-05: First-in-class T cell-redirecting bispecific antibody targeting glypican-3: a highly tumor-selective antigen by Ishiguro, Takahiro, Kinoshita, Yasuko, Sano, Yuji, Azuma, Yumiko, Tsunenari, Toshiaki, Ono, Natsuki, Kayukawa, Yoko, Kamata-Sakurai, Mika, Shiraiwa, Hirotake, Kaneko, Akihisa, Frings, Werner, Komatsu, Shunichiro, Nezu, Junichi, Endo, Mika

“…Immune checkpoint inhibitors such as anti-PD1 antibodies have shown promising clinical responses in several solid tumors, however there remain patients who do…”
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Abstract 1482: Anti-GPC3 TRAB, a first-in-class T cell-redirecting bispecific antibody targeting glypican-3 with potent in vitro and in vivo antitumor efficacy against solid tumors by Kinoshita, Yasuko, Ishiguro, Takahiro, Sano, Yuji, Azuma, Yumiko, Tsunenari, Toshiaki, Ono, Natsuki, Kayukawa, Yoko, Ueda, Otoya, Wada, Naoko A., Hino, Hiroshi, Jishage, Koichi, Shiraiwa, Hirotake, Kamata-Sakurai, Mika, Nezu, Junichi, Endo, Mika

“…We present efficacy data for the T cell-redirecting antibody (TRAB) with highly potent anti-tumor efficacy. Anti-Glypican-3 (GPC3) TRAB is a humanized IgG4…”
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