Search Results - "Kamai, Yasuki"

A Novel HER3-Targeting Antibody-Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization by Hashimoto, Yuuri, Koyama, Kumiko, Kamai, Yasuki, Hirotani, Kenji, Ogitani, Yusuke, Zembutsu, Akiko, Abe, Manabu, Kaneda, Yuki, Maeda, Naoyuki, Shiose, Yoshinobu, Iguchi, Takuma, Ishizaka, Tomomichi, Karibe, Tsuyoshi, Hayakawa, Ichiro, Morita, Koji, Nakada, Takashi, Nomura, Taisei, Wakita, Kenichi, Kagari, Takashi, Abe, Yuki, Murakami, Masato, Ueno, Suguru, Agatsuma, Toshinori

“…HER3 is a compelling target for cancer treatment; however, no HER3-targeted therapy is currently clinically available. Here, we produced U3-1402, an anti-HER3…”
Get full text

The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models by Katayama, Ryohei, Gong, Bo, Togashi, Noriko, Miyamoto, Masaya, Kiga, Masaki, Iwasaki, Shiho, Kamai, Yasuki, Tominaga, Yuichi, Takeda, Yasuyuki, Kagoshima, Yoshiko, Shimizu, Yuki, Seto, Yosuke, Oh-hara, Tomoko, Koike, Sumie, Nakao, Naoki, Hanzawa, Hiroyuki, Watanabe, Kengo, Yoda, Satoshi, Yanagitani, Noriko, Hata, Aaron N., Shaw, Alice T., Nishio, Makoto, Fujita, Naoya, Isoyama, Takeshi

“…ROS1 gene rearrangement was observed in around 1–2 % of NSCLC patients and in several other cancers such as cholangiocarcinoma, glioblastoma, or colorectal…”
Get full text

EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd by Haikala, Heidi M, Lopez, Timothy, Köhler, Jens, Eser, Pinar O, Xu, Man, Zeng, Qing, Teceno, Tyler J, Ngo, Kenneth, Zhao, Yutong, Ivanova, Elena V, Bertram, Arrien A, Leeper, Brittaney A, Chambers, Emily S, Adeni, Anika E, Taus, Luke J, Kuraguchi, Mari, Kirschmeier, Paul T, Yu, Channing, Shiose, Yoshinobu, Kamai, Yasuki, Qiu, Yang, Paweletz, Cloud P, Gokhale, Prafulla C, Jänne, Pasi A

“…Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are the standard-of-care treatment for -mutant non-small cell lung cancers (NSCLC)…”
Get full text

Correlation between penicillin-binding protein 2 mutations and carbapenem resistance in Escherichia coli by YAMACHIKA, Shinichiro, SUGIHARA, Chika, KAMAI, Yasuki, YAMASHITA, Makoto

“…It is well known that carbapenem-resistant mutations in penicillin-binding proteins (PBPs) are not observed in most Gram-negative bacteria under either…”
Get full text

Anti-Pseudomonas aeruginosa Compound, 1,2,3,4-Tetrahydro-1,3,5-triazine Derivative, Exerts Its Action by Primarily Targeting MreB by Yamachika, Shinichiro, Sugihara, Chika, Tsuji, Hayato, Muramatsu, Yasunori, Kamai, Yasuki, Yamashita, Makoto

“…In order to find new anti-Pseudomonas agents, we carried out whole-cell based P. aeruginosa growth assay, and identified 1,2,3,4-tetrahydro-1,3,5-triazine…”
Get full text

Anti-Pseudomonas aeruginosa Compound, 1,2,3,4-Tetrahydro-1,3,5-triazine Derivative, Exerts Its Action by Primarily Targeting MreB by Shinichiro Yamachika, Chika Sugihara, Hayato Tsuji, Yasunori Muramatsu, Yasuki Kamai, Makoto Yamashita

“…In order to find new anti-Pseudomonas agents, we carried out whole-cell based P.aeruginosa growth assay, and identified 1,2,3,4-tetrahydro-1,3,5-triazine…”
Get full text

Synthesis, cleavage, and antifungal activity of a number of novel, water-soluble ester prodrugs of antifungal triazole CS-758 by Kagoshima, Yoshiko, Mori, Makoto, Suzuki, Eiko, Shibayama, Takahiro, Iida, Tamako, Kamai, Yasuki, Konosu, Toshiyuki

“…Synthesis and evaluation of some esters of CS-758, as injectable prodrugs, are described. The phosphoryl ester 1a was converted to CS-758 in vivo. In this…”
Get full text

Design, Synthesis and Antifungal Activity of the Novel Water-Soluble Prodrug of Antifungal Triazole CS-758 by Kagoshima, Yoshiko, Mori, Makoto, Suzuki, Eiko, Kobayashi, Nobue, Shibayama, Takahiro, Kubota, Mikie, Kamai, Yasuki, Konosu, Toshiyuki

“…CS-758 was selected as a candidate for clinical trials, but since its water-solubility was insufficient for an injectable formulation, phosphoryl ester…”
Get full text

New Model of Oropharyngeal Candidiasis in Mice by KAMAI, Yasuki, KUBOTA, Mikie, KAMAI, Yoko, HOSOKAWA, Tsunemichi, FUKUOKA, Takashi, FILLER, Scott G

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Contribution of Candida albicans ALS1 to the Pathogenesis of Experimental Oropharyngeal Candidiasis by KAMAI, Yasuki, KUBOTA, Mikie, KAMAI, Yoko, HOSOKAWA, Tsunemichi, FUKUOKA, Takashi, FILLER, Scott G

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Antifungal Activities of R-135853, a Sordarin Derivative, in Experimental Candidiasis in Mice by KAMAI, Yasuki, KAKUTA, Masayo, SHIBAYAMA, Takahiro, FUKUOKA, Takashi, KUWAHARA, Shogo

“…ERRATUM ( vol. 49 , p. 1269 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
Get full text

In Vitro and In Vivo Activities of CS-758 (R-120758), a New Triazole Antifungal Agent by KAMAI, Yasuki, HARASAKI, Tamako, FUKUOKA, Takashi, OHYA, Satoshi, UCHIDA, Katsuhisa, YAMAGUCHI, Hideyo, KUWAHARA, Shogo

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Synthesis and Antifungal Activities of R-102557 and Related Dioxane-Triazole Derivatives by OIDA, Sadao, TAJIMA, Yawara, KONOSU, Toshiyuki, NAKAMURA, Yoshie, SOMADA, Atsushi, TANAKA, Teruo, HABUKI, Shinobu, HARASAKI, Tamako, KAMAI, Yasuki, FUKUOKA, Takashi, OHYA, Satoshi, YASUDA, Hiroshi

“…Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11-13 under acidic…”
Get full text

Characterization of Mechanisms of Fluconazole Resistance in a Candida albicans Isolate from a Japanese Patient with Chronic Mucocutaneous Candidiasis by Kamai, Yasuki, Maebashi, Kazunori, Kudoh, Michinari, Makimura, Koichi, Naka, Wataru, Uchida, Katsuhisa, Yamaguchi, Hideyo

“…We examined the mechanisms of fluconazole resistance in a fluconazole‐resistant Candida albicans isolate from a Japanese patient with chronic mucocutaneous…”
Get full text

Efficacy of CS-758, a Novel Triazole, against Experimental Fluconazole-Resistant Oropharyngeal Candidiasis in Mice by KAMAI, Yasuki, KUBOTA, Mikie, FUKUOKA, Takashi, KAMAI, Yoko, MAEDA, Naoyuki, HOSOKAWA, Tsunemichi, SHIBAYAMA, Takahiro, UCHIDA, Katsuhisa, YAMAGUCHI, Hideyo, KUWAHARA, Shogo

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Synthesis and in Vitro Antifungal Activities of Novel Triazole Antifungal Agent CS-758 by KONOSU, Toshiyuki, OIDA, Sadao, NAKAMURA, Yoshie, SEKI, Shinobu, UCHIDA, Takuya, SOMADA, Atsushi, MORI, Makoto, HARADA, Yoshiko, KAMAI, Yasuki, HARASAKI, Tamako, FUKUOKA, Takashi, OHYA, Satoshi, YASUDA, Hiroshi, SHIBAYAMA, Takahiro, INOUE, Shin-ichi, NAKAGAWA, Akihiko, SETA, Yasuo

“…Synthesis and in vitro antifungal activities of a novel triazole antifungal agent CS-758 (former name, R-120758) are described. The minimum inhibitory…”
Get full text

Proliferation of Intracellular Structure Corresponding to Reduced Affinity of Fluconazole for Cytochrome P-450 in Two Low-Susceptibility Strains of Candida albicans Isolated from a Japanese AIDS Patient by Maebashi, Kazunori, Kudoh, Michinari, Nishiyama, Yayoi, Makimura, Koichi, Kamai, Yasuki, Uchida, Katsuhisa, Yamaguchi, Hideyo

“…Three Candida albicans isolates, TIMM 3164, 3165 and 3166 with reduced fluconazole susceptibility, were isolated from two Japanese AIDS patients. We earlier…”
Get full text

Abstract 5376: Pleclinical investigation of T-DXd internalization and payload release in HER2 mutant non-small cell lung cancer cells by Yamasaki, Atsushi, Ikuta, Misa, Abe, Manabu, Deguchi, Tsuneo, Kamai, Yasuki, Nakamaru, Kenji, Agatsuma, Toshinori

“…Abstract Introduction: T-DXd (trastuzumab deruxtecan) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2) composed of…”
Get full text

Regulation of Insulin-like Growth Factor-I Expression in Mouse Preadipocyte Ob1771 Cells by Kamai, Y, Mikawa, S, Endo, K, Sakai, H, Komano, T

“…In mouse preadipocyte Ob1771 cells, transcription of the insulin-like growth factor-I (IGF-I) gene was stimulated by growth hormone (GH), and IGF-I protein…”
Get full text

Abstract LB-275: U3-1402, a novel HER3-targeting antibody-drug conjugate, exhibits its antitumor activity through increased payload intracellular delivery via highly efficient drug internalization by Koyama, Kumiko, Hashimoto, Yuuri, Kamai, Yasuki, Shiose, Yoshinobu, Abe, Manabu, Kaneda, Yuki, Maeda, Naoyuki, Hirotani, Kenji, Ogitani, Yusuke, Karibe, Tsuyoshi, Kagari, Takashi, Wakita, Kenichi, Ueno, Suguru, Agatsuma, Toshinori, Murakami, Masato

“…Abstract Background: Human epidermal growth factor receptor 3 (HER3), a member of the ErbB receptor tyrosine kinase family, is overexpressed in a variety of…”
Get full text