Search Results - "Kam, Monica"

Azole Fungicides and Their Endocrine Disrupting Properties: Perspectives on Sex Hormone-Dependent Reproductive Development by Draskau, Monica Kam, Svingen, Terje

“…Azoles are antifungal agents used in both agriculture and medicine. They typically target the CYP51 enzyme in fungi and, by so doing, disrupt cell membrane…”
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A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation by Svingen, Terje, Villeneuve, Daniel L, Knapen, Dries, Panagiotou, Eleftheria Maria, Draskau, Monica Kam, Damdimopoulou, Pauliina, O’Brien, Jason M

“…Abstract The adverse outcome pathway (AOP) framework provides a practical means for organizing scientific knowledge that can be used to infer cause-effect…”
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Using alternative test methods to predict endocrine disruption and reproductive adverse outcomes: do we have enough knowledge? by Svingen, Terje, Schwartz, Camilla Lindgren, Rosenmai, Anna Kjerstine, Ramhøj, Louise, Johansson, Hanna Katarina Lilith, Hass, Ulla, Draskau, Monica Kam, Davidsen, Nichlas, Christiansen, Sofie, Ballegaard, Anne-Sofie Ravn, Axelstad, Marta

“…Endocrine disrupting chemicals (EDCs) are a matter of great concern. They are ubiquitous in the environment, are considered harmful to humans and wildlife, yet…”
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AOP Key Event Relationship report: Linking decreased retinoic acid levels with disrupted meiosis in developing oocytes by Kam Draskau, Monica, Ravn Ballegaard, Anne-Sofie, Ramhøj, Louise, Bowles, Josephine, Svingen, Terje, Spiller, Cassy M.

“…[Display omitted] •The first case study to develop and publish an individual KER as a stand-alone unit of information under the AOP framework overseen by the…”
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Increased precursor cell proliferation after deep brain stimulation for Parkinson's disease: a human study by Vedam-Mai, Vinata, Gardner, Bronwen, Okun, Michael S, Siebzehnrubl, Florian A, Kam, Monica, Aponso, Palingu, Steindler, Dennis A, Yachnis, Anthony T, Neal, Dan, Oliver, Brittany U, Rath, Sean J, Faull, Richard L M, Reynolds, Brent A, Curtis, Maurice A

“…Deep brain stimulation (DBS) has been used for more than a decade to treat Parkinson's disease (PD); however, its mechanism of action remains unknown. Given…”
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The cellular composition and morphological organization of the rostral migratory stream in the adult human brain by Kam, Monica, Curtis, Maurice A., McGlashan, Susan R., Connor, Bronwen, Nannmark, Ulf, Faull, Richard L.M.

“…The rostral migratory stream (RMS) is the major pathway by which progenitor cells migrate from the subventricular zone (SVZ) to the olfactory bulb (OB) in…”
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In vitro and in vivo endocrine disrupting effects of the azole fungicides triticonazole and flusilazole by Draskau, Monica Kam, Boberg, Julie, Taxvig, Camilla, Pedersen, Mikael, Frandsen, Henrik Lauritz, Christiansen, Sofie, Svingen, Terje

“…Azoles are effective antifungal agents used in both medicine and agriculture. They typically work by inhibiting cytochrome P450 enzymes, primarily CYP51 of the…”
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Transcriptome analysis of fetal rat testis following intrauterine exposure to the azole fungicides triticonazole and flusilazole reveals subtle changes despite adverse endocrine effects by Draskau, Monica Kam, Lardenois, Aurélie, Evrard, Bertrand, Boberg, Julie, Chalmel, Frédéric, Svingen, Terje

“…Azoles are used in agriculture and medicine to combat fungal infections. We have previously examined the endocrine disrupting properties of the agricultural…”
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Human-relevant concentrations of the antifungal drug clotrimazole disrupt maternal and fetal steroid hormone profiles in rats by Draskau, Monica Kam, Rosenmai, Anna Kjerstine, Scholze, Martin, Pedersen, Mikael, Boberg, Julie, Christiansen, Sofie, Svingen, Terje

“…Clotrimazole is a non-prescription and broad-spectrum antifungal drug sold under brand names such as Canesten® and Lotrimin®. It is used to treat different…”
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The anti-androgenic fungicide triticonazole induces region-specific transcriptional changes in the developing rat perineum and phallus by Draskau, Monica Kam, Schwartz, Camilla Lindgren, Evrard, Bertrand, Lardenois, Aurélie, Pask, Andrew, Chalmel, Frédéric, Svingen, Terje

“…Intrauterine exposure to endocrine disrupting chemicals can interfere with male reproductive development. This can lead to male reproductive disorders such as…”
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Classical toxicity endpoints in female rats are insensitive to the human endocrine disruptors diethylstilbestrol and ketoconazole by Johansson, Hanna K.L., Christiansen, Sofie, Draskau, Monica Kam, Svingen, Terje, Boberg, Julie

“…•Current endpoints used for female reproductive toxicity are not sensitive enough.•New and improved test methods for female reproductive toxicity are…”
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Developmental biology meets toxicology: contributing reproductive mechanisms to build adverse outcome pathways by Draskau, Monica Kam, Spiller, Cassy M, Boberg, Julie, Bowles, Josephine, Svingen, Terje

“…Abstract An adverse outcome pathway (AOP) is a simplified description of the sequence of mechanistic events that lead to a particular toxicological effect,…”
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AOP key event relationship report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles by Panagiotou, Eleftheria Maria, Draskau, Monica Kam, Li, Tianyi, Hirschberg, Angelica, Svingen, Terje, Damdimopoulou, Pauliina

“…We recently proposed to formally recognize Key Event Relationships (KERs) as building blocks of Adverse Outcome Pathways (AOPs) that can be independently…”
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Exposure to the pesticides linuron, dimethomorph and imazalil alters steroid hormone profiles and gene expression in developing rat ovaries by Boberg, Julie, Johansson, Hanna K.L., Franssen, Delphine, Draskau, Monica Kam, Christiansen, Sofie, Cramer, Johannah, Pedersen, Mikael, Parent, Anne-Simone, Svingen, Terje

“…Inhibition of androgen signaling during critical stages of ovary development can disrupt folliculogenesis with potential consequences for reproductive function…”
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Neurogenesis in humans by Curtis, Maurice A., Kam, Monica, Faull, Richard L. M.

“…Since 1944 increasing evidence has been emerging that the adult human brain harbours progenitor cells with the potential to produce neuroblasts. However, it…”
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Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension by Curtis, Maurice A, Kam, Monica, Nannmark, Ulf, Anderson, Michelle F, Axell, Mathilda Zetterstrom, Wikkelso, Carsten, Holtås, Stig, van Roon-Mom, Willeke M.C, Björk-Eriksson, Thomas, Nordborg, Claes, Frisén, Jonas, Dragunow, Michael, Faull, Richard L.M, Eriksson, Peter S

“…The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS…”
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Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals by Johansson, Hanna K. L., Damdimopoulou, Pauliina, van Duursen, Majorie B. M., Boberg, Julie, Franssen, Delphine, de Cock, Marijke, Jääger, Kersti, Wagner, Magdalena, Velthut-Meikas, Agne, Xie, Yuling, Connolly, Lisa, Lelandais, Pauline, Mazaud-Guittot, Severine, Salumets, Andres, Draskau, Monica Kam, Filis, Panagiotis, Fowler, Paul A., Christiansen, Sofie, Parent, Anne-Simone, Svingen, Terje

“…Modern living challenges female reproductive health. We are witnessing a rise in reproductive disorders and drop in birth rates across the world. The reasons…”
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Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project by Svingen, Terje, Andersson, Anna-Maria, Angelova, Julianna, Axelstad, Marta, Bakker, Julie, Baumann, Lisa, Beronius, Anna, Bouftas, Nora, Chalmel, Frederic, Christiansen, Sofie, Cornil, Charlotte, Damdimopoulou, Pauliina, Deepika, Deepika, Dollé, Martijn E T, Draskau, Monica Kam, Fischer, Margit Bistrup, Hagen, Casper P, Hessel, Ellen, Holmer, Marie Louise, Hughes, Samantha, Jensen, Genon, Johansson, Hanna Katarina Lilith, Juul, Anders, Kumar, Vikas, Kumar, Saurav, Lardenois, Aurélie, Main, Katharina M, Mazaud-Guittot, Severine, Moe, S Jannicke, Mola, Gylli, Parent, Anne-Simone, Pineda, Rafael, Rolland, Antoine, Rosenmai, Anna Kjerstine, Song, You, Suglia, Antonio, Tena-Sempere, Manuel, Wehrli, Lydia, Zilliacus, Johanna, van Duursen, Majorie

“…The prevalence of hormone-related health issues caused by exposure to endocrine disrupting chemicals (EDCs) is a significant, and increasing, societal…”
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Faculty development for strengthening online teaching capability: a mixed-methods study of what staff want, evaluated with Kirkpatrick’s model of teaching effectiveness [version 2; peer review: 2 approved] by Tanisha Jowsey, Amanda Charlton, Daniela Ruiz Cosignani, Rachelle Singleton, Megan Clune, Monica Kam

“…Background Globally, tertiary teachers are increasingly being pushed and pulled into online teaching. While most developments in online education have focused…”
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Response to Comment on "Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension" by Curtis, Maurice A., Kam, Monica, Nannmark, Ulf, Faull, Richard L.M., Eriksson, Peter S.

“…In contrast to a previous study of Sanai et al ., our study had the advantage of using serial sagittal sections of the human basal forebrain, combined with…”
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