Search Results - "Kaluzhskiy, Leonid"

Protein Interactome Profiling of Stable Molecular Complexes in Biomaterial Lysate by Mezentsev, Yuri, Ershov, Pavel, Yablokov, Evgeniy, Kaluzhskiy, Leonid, Kupriyanov, Konstantin, Gnedenko, Oksana, Ivanov, Alexis

“…Most proteins function as part of various complexes, forming via stable and dynamic protein-protein interactions (PPIs). The profiling of PPIs expands the…”
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Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells by Pislyagin, Evgeny A, Menchinskaya, Ekaterina S, Gladkikh, Irina N, Kvetkina, Aleksandra N, Sintsova, Oksana V, Popkova, Darya V, Kozlovskiy, Sergei A, Gorpenchenko, Tatiana Y, Likhatskaya, Galina N, Kaluzhskiy, Leonid A, Ivanov, Alexis S, Andreev, Yaroslav A, Kozlov, Sergey A, Dmitrenok, Pavel S, Aminin, Dmitry L, Leychenko, Elena V

“…Purinergic P2X7 receptors (P2X7) have now been proven to play an important role and represent an important therapeutic target in many pathological conditions…”
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SPR Biosensors in Direct Molecular Fishing: Implications for Protein Interactomics by Florinskaya, Anna, Ershov, Pavel, Mezentsev, Yuri, Kaluzhskiy, Leonid, Yablokov, Evgeniy, Medvedev, Alexei, Ivanov, Alexis

“…We have developed an original experimental approach based on the use of surface plasmon resonance (SPR) biosensors, applicable for investigation of potential…”
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Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3'-Disulfate by Kaluzhskiy, Leonid, Ershov, Pavel, Yablokov, Evgeniy, Shkel, Tatsiana, Grabovec, Irina, Mezentsev, Yuri, Gnedenko, Oksana, Usanov, Sergey, Shabunya, Polina, Fatykhava, Sviatlana, Popov, Alexander, Artyukov, Aleksandr, Styshova, Olga, Gilep, Andrei, Strushkevich, Natallia, Ivanov, Alexis

“…Widespread pathologies such as atherosclerosis, metabolic syndrome and cancer are associated with dysregulation of sterol biosynthesis and metabolism…”
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Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context by Ershov, Pavel, Kaluzhskiy, Leonid, Mezentsev, Yuri, Yablokov, Evgeniy, Gnedenko, Oksana, Ivanov, Alexis

“…A global protein interactome ensures the maintenance of regulatory, signaling and structural processes in cells, but at the same time, aberrations in the…”
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Tetracyclic 1,4-Naphthoquinone Thioglucoside Conjugate U-556 Blocks the Purinergic P2X7 Receptor in Macrophages and Exhibits Anti-Inflammatory Activity In Vivo by Kozlovskiy, Sergei, Pislyagin, Evgeny, Menchinskaya, Ekaterina, Chingizova, Ekaterina, Kaluzhskiy, Leonid, Ivanov, Alexis S, Likhatskaya, Galina, Agafonova, Irina, Sabutski, Yuri, Polonik, Sergey, Manzhulo, Igor, Aminin, Dmitry

“…P2X7 receptors (P2X7Rs) are ligand-gated ion channels that play a significant role in inflammation and are considered a potential therapeutic target for some…”
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The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis by Tumilovich, Anastasiya, Yablokov, Evgeniy, Mezentsev, Yuri, Ershov, Pavel, Basina, Viktoriia, Gnedenko, Oksana, Kaluzhskiy, Leonid, Tsybruk, Tatsiana, Grabovec, Irina, Kisel, Maryia, Shabunya, Polina, Soloveva, Natalia, Vavilov, Nikita, Gilep, Andrei, Ivanov, Alexis

“…Dehydroepiandrosterone (DHEA), a precursor of steroid sex hormones, is synthesized by steroid 17-alpha-hydroxylase/17,20-lyase (CYP17A1) with the participation…”
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Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson's Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation by Kvetkina, Aleksandra, Pislyagin, Evgeny, Menchinskaya, Ekaterina, Yurchenko, Ekaterina, Kalina, Rimma, Kozlovskiy, Sergei, Kaluzhskiy, Leonid, Menshov, Alexander, Kim, Natalia, Peigneur, Steve, Tytgat, Jan, Ivanov, Alexis, Ayvazyan, Naira, Leychenko, Elena, Aminin, Dmitry

“…Parkinson's disease (PD) is a socially significant disease, during the development of which oxidative stress and inflammation play a significant role. Here, we…”
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A large-scale comparative analysis of affinity, thermodynamics and functional characteristics of interactions of twelve cytochrome P450 isoforms and their redox partners by Yablokov, Evgeniy O., Sushko, Tatsiana A., Ershov, Pavel V., Florinskaya, Anna V., Gnedenko, Oksana V., Shkel, Tatsiana V., Grabovec, Irina P., Strushkevich, Natallia V., Kaluzhskiy, Leonid A., Usanov, Sergey A., Gilep, Andrei A., Ivanov, Alexis S.

“…The aim of the present work was to establish the thermodynamic and functional differences in the protein-protein interactions between the components of the…”
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A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine by Kvetkina, Aleksandra, Leychenko, Elena, Chausova, Victoria, Zelepuga, Elena, Chernysheva, Nadezhda, Guzev, Konstantin, Pislyagin, Evgeny, Yurchenko, Ekaterina, Menchinskaya, Ekaterina, Aminin, Dmitry, Kaluzhskiy, Leonid, Ivanov, Alexis, Peigneur, Steve, Tytgat, Jan, Kozlovskaya, Emma, Isaeva, Marina

“…The Kunitz/BPTI-type peptides are ubiquitous in numerous organisms including marine venomous animals. The peptides demonstrate various biological activities…”
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Mechanism of the Affinity-Enhancing Effect of Isatin on Human Ferrochelatase and Adrenodoxin Reductase Complex Formation: Implication for Protein Interactome Regulation by Ershov, Pavel V, Veselovsky, Alexander V, Mezentsev, Yuri V, Yablokov, Evgeniy O, Kaluzhskiy, Leonid A, Tumilovich, Anastasiya M, Kavaleuski, Anton A, Gilep, Andrei A, Moskovkina, Taisiya V, Medvedev, Alexei E, Ivanov, Alexis S

“…Isatin (indole-2, 3-dione) is a non-peptide endogenous bioregulator exhibiting a wide spectrum of biological activity, realized in the cell via interactions…”
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Phenanthridine derivatives as potential HIV‑1 protease inhibitors by Ershov, Pavel V, Mezentsev, Yuri V, Kaluzhskiy, Leonid A, Ivanov, Alexis S

“…In the present study, the antiviral activity of phenanthridine derivatives was assessed. In total, the inhibitory effect of eight structurally similar…”
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Phanogracilins A-C, New Bibenzochromenones of Crinoid Phanogenia gracilis (Hartlaub, 1890) by Vasileva, Elena A, Berdyshev, Dmitrii V, Mishchenko, Natalia P, Gerasimenko, Andrey V, Menchinskaya, Ekaterina S, Pislyagin, Evgeniy A, Chingizova, Ekaterina A, Kaluzhskiy, Leonid A, Dautov, Salim Sh, Fedoreyev, Sergey A

“…Three new bibenzochromenones named phanogracilins A-C ( - ) were isolated from the crinoid . The structure of was established using X-ray crystallography as…”
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Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors by Ershov, Pavel V, Yablokov, Evgeniy O, Kaluzhskiy, Leonid A, Mezentsev, Yuri V, Ivanov, Alexis S

“…Cancer-associated disturbance of prostanoid signaling provides an aberrant accumulation of prostanoids. This signaling consists of 19 target genes, encoding…”
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Insights into Ergosterol Peroxide's Trypanocidal Activity by Meza-Menchaca, Thuluz, Ramos-Ligonio, Angel, López-Monteon, Aracely, Vidal Limón, Abraham, Kaluzhskiy, Leonid A, V Shkel, Tatjana, V Strushkevich, Natallia, Jiménez-García, Luis Felipe, Agredano Moreno, Lourdes Teresa, Gallegos-García, Verónica, Suárez-Medellín, Jorge, Trigos, Ángel

“…, which causes Chagas disease, is a significant health threat in many countries and affects millions of people. Given the magnitude of this disease, a broader…”
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Molecular Cloning, Heterologous Expression, Purification, and Evaluation of Protein–Ligand Interactions of CYP51 of Candida krusei Azole-Resistant Fungal Strain by Tsybruk, Tatsiana V., Kaluzhskiy, Leonid A., Mezentsev, Yuri V., Makarieva, Tatyana N., Tabakmaher, Kseniya M., Ivanchina, Natalia V., Dmitrenok, Pavel S., Baranovsky, Alexander V., Gilep, Andrei A., Ivanov, Alexis S.

“…Due to the increasing prevalence of fungal diseases caused by fungi of the genus Candida and the development of pathogen resistance to available drugs, the…”
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Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome by Ershov, Pavel V, Mezentsev, Yuri V, Kopylov, Arthur T, Yablokov, Evgeniy O, Svirid, Andrey V, Lushchyk, Aliaksandr Ya, Kaluzhskiy, Leonid A, Gilep, Andrei A, Usanov, Sergey A, Medvedev, Alexey E, Ivanov, Alexis S

“…Prostacyclin synthase (PTGIS; EC 5.3.99.4) catalyzes isomerization of prostaglandin H to prostacyclin, a potent vasodilator and inhibitor of platelet…”
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Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450 by Gilep, Andrei, Varaksa, Tatsiana, Bukhdruker, Sergey, Kavaleuski, Anton, Ryzhykau, Yury, Smolskaya, Sviatlana, Sushko, Tatsiana, Tsumoto, Kouhei, Grabovec, Irina, Kapranov, Ivan, Okhrimenko, Ivan, Marin, Egor, Shevtsov, Mikhail, Mishin, Alexey, Kovalev, Kirill, Kuklin, Alexander, Gordeliy, Valentin, Kaluzhskiy, Leonid, Gnedenko, Oksana, Yablokov, Evgeniy, Ivanov, Alexis, Borshchevskiy, Valentin, Strushkevich, Natallia

“…Ferredoxins are small iron-sulfur proteins and key players in essential metabolic pathways. Among all types, 3Fe-4S ferredoxins are less studied mostly due to…”
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The effect of membrane composition on the interaction between human CYP51 and its flavonoid inhibitor - luteolin 7,3′-disulfate by Kaluzhskiy, Leonid, Yablokov, Evgeniy, Gnedenko, Oksana, Burkatovskii, Dmitrii, Maslov, Ivan, Bogorodskiy, Andrey, Ershov, Pavel, Tsybruk, Tatsiana, Zelepuga, Elena, Rutckova, Tatyana, Kozlovskaya, Emma, Dmitrenok, Pavel, Gilep, Andrei, Borshchevskiy, Valentin, Strushkevich, Natallia, Ivanov, Alexis

“…Cytochromes P450 (CYP) are a family of membrane proteins involved in the production of endogenous molecules and the metabolism of xenobiotics. It is well-known…”
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Structural insights into the effects of glycerol on ligand binding to cytochrome P450 by Bukhdruker, Sergey, Varaksa, Tatsiana, Orekhov, Philipp, Grabovec, Irina, Marin, Egor, Kapranov, Ivan, Kovalev, Kirill, Astashkin, Roman, Kaluzhskiy, Leonid, Ivanov, Alexis, Mishin, Alexey, Rogachev, Andrey, Gordeliy, Valentin, Gilep, Andrei, Strushkevich, Natallia, Borshchevskiy, Valentin

“…New antitubercular drugs are vital due to the spread of resistant strains. Carbethoxyhexyl imidazole (CHImi) inhibits cytochrome P450 CYP124, which is a…”
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