Search Results - "Kalson, Nicholas S."

Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization by Starborg, Tobias, Kalson, Nicholas S, Lu, Yinhui, Mironov, Aleksandr, Cootes, Timothy F, Holmes, David F, Kadler, Karl E

“…Collagen fibrils are the major tensile element in vertebrate tissues, in which they occur as ordered bundles in the extracellular matrix. Abnormal fibril…”
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A structure-based extracellular matrix expansion mechanism of fibrous tissue growth by Kalson, Nicholas S, Lu, Yinhui, Taylor, Susan H, Starborg, Tobias, Holmes, David F, Kadler, Karl E

“…Embryonic growth occurs predominately by an increase in cell number; little is known about growth mechanisms later in development when fibrous tissues account…”
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Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane by Kalson, Nicholas S, Starborg, Tobias, Lu, Yinhui, Mironov, Aleksandr, Humphries, Sally M, Holmes, David F, Kadler, Karl E

“…Collagen fibrils can exceed thousands of microns in length and are therefore the longest, largest, and most size-pleomorphic protein polymers in vertebrates;…”
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Reduced telomere length is associated with fibrotic joint disease suggesting that impaired telomere repair contributes to joint fibrosis by Kalson, Nicholas S, Brock, Tim M, Mangino, Massimo, Fabiane, Stella M, Mann, Derek A, Borthwick, Lee A, Deehan, David J, Williams, Frances M K

“…Joint fibrosis affects many synovial joints (including hip, knee and shoulder) causing stiffness and pain. The mechanism of joint fibrosis remains unknown,…”
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Joint Stiffness Is Heritable and Associated with Fibrotic Conditions and Joint Replacement by Williams, Frances M, Kalson, Nicholas S, Fabiane, Stella M, Mann, Derek A, Deehan, David J

“…Joint stiffness is a common, debilitating, age-related symptom, which may be seen after total joint replacement (TJR). Stiffness also occurs in fibrotic…”
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Matrix metalloproteinase 14 is required for fibrous tissue expansion by Taylor, Susan H, Yeung, Ching-Yan Chloé, Kalson, Nicholas S, Lu, Yinhui, Zigrino, Paola, Starborg, Tobias, Warwood, Stacey, Holmes, David F, Canty-Laird, Elizabeth G, Mauch, Cornelia, Kadler, Karl E

“…Type I collagen-containing fibrils are major structural components of the extracellular matrix of vertebrate tissues, especially tendon, but how they are…”
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Do changes in gastro-intestinal blood flow explain high-altitude anorexia? by Kalson, Nicholas S., Hext, Faye, Davies, Andrew J., Chan, Colin W. M., Wright, Alex D., Imray, Christopher H. E.

“…Eur J Clin Invest 2010; 40 (8): 735–741 Background  Gastrointestinal symptoms are common on acute exposure to high‐altitude (HA). Underlying mechanisms are not…”
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Determinants of Summiting Success and Acute Mountain Sickness on Mt Kilimanjaro (5895 m) by Davies, Andrew J, Kalson, Nicholas S, Stokes, Suzy, Earl, Mark D, Whitehead, Adam G, Frost, Hannah, Tyrell-Marsh, Ian, Naylor, Jon

“…Objective.—To determine the incidence of acute mountain sickness (AMS), the frequency of summiting success, and the factors that affect these in trekkers on…”
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The effect of angiotensin-converting enzyme genotype on acute mountain sickness and summit success in trekkers attempting the summit of Mt. Kilimanjaro (5,895 m) by Kalson, Nicholas S., Thompson, Julian, Davies, Andrew J., Stokes, Suzy, Earl, Mark D., Whitehead, Adam, Tyrrell-Marsh, Ian, Frost, Hannah, Montgomery, Hugh

“…The I-allele rather than the D-allele of the human angiotensin converting enzyme (ACE) gene has been associated with high-altitude mountaineering success. We…”
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Destructive Synovial Hemangioma of the Hip Resembling Pigmented Villonodular Synovitis by Kalson, Nicholas S., BSc (Hons), Gikas, Panagiotis D., MRCS, Tirabosco, Roberto, FRCPath, O'Donnell, Paul, FRCR, Skinner, John A., FRCS, Flanagan, Adrienne M., FRCPath

“…Abstract We report a case of synovial hemangioma of the hip causing joint destruction severe enough to warrant arthroplasty in a 32-year-old man who presented…”
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Quantification and severity grading of femoral vessel compression by adverse reactions to metal debris in metal-on-metal total hip arthroplasty by Al-Khatib, Yousef, Tyas, Ben, Kalson, Nicholas S, Agni, Nickil, Bhutani, Priyesh, Petheram, Timothy, Carluke, Ian, Partington, Paul

“…Introduction: Metal-on-metal (MoM) total hip arthroplasty (THA) may cause adverse reactions to metal debris (ARMD). ARMD causing femoral vessel compression…”
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Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2 by Paish, Hannah L., Kalson, Nicholas S., Smith, Graham R., del Carpio Pons, Alicia, Baldock, Thomas E., Smith, Nicholas, Swist-Szulik, Katarzyna, Weir, David J., Bardgett, Michelle, Deehan, David J., Mann, Derek A., Borthwick, Lee A.

“…Fibroblasts persist within fibrotic scar tissue and exhibit considerable phenotypic and functional plasticity. Herein, we hypothesized that scar-associated…”
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Quantification of intra-articular fibrosis in patients with stiff knee arthroplasties using metal-reduction MRI by Attard, Veronica, Li, Cheuk Yin, Self, Alexander, Mann, Derek A, Borthwick, Lee A, O'Connor, Phil, Deehan, David J, Kalson, Nicholas S

“…Stiffness is a common complication after total knee arthroplasty (TKA). Pathogenesis is not understood, treatment options are limited, and diagnosis is…”
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Chronic, Active Inflammation in Patients With Failed Total Knee Replacements Undergoing Revision Surgery by Paish, Hannah L., Baldock, Thomas Edward, Gillespie, Colin S., del Carpio Pons, Alicia, Mann, Derek A., Deehan, David J., Borthwick, Lee A., Kalson, Nicholas S.

“…ABSTRACT Chronic pain and restricted knee motion is a significant problem following the total knee arthroplasty (TKA). The molecular pathogenesis of pain…”
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Synchronized mechanical oscillations at the cell–matrix interface in the formation of tensile tissue by Holmes, David F., Yeung, Ching-Yan Chloé, Garva, Richa, Zindy, Egor, Taylor, Susan H., Lu, Yinhui, Watsona, Simon, Kalson, Nicholas S., Kadler, Karl E.

“…The formation of uniaxial fibrous tissues with defined viscoelastic properties implies the existence of an orchestrated mechanical interaction between the…”
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Slow stretching that mimics embryonic growth rate stimulates structural and mechanical development of tendon‐like tissue in vitro by Kalson, Nicholas S., Holmes, David F., Herchenhan, Andreas, Lu, Yinhui, Starborg, Toby, Kadler, Karl E.

“…A distinctive feature of embryonic tendon development is the steady increase in collagen fibril diameter and associated improvement of tissue mechanical…”
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Post-radiation sciatic neuropathy: a case report and review of the literature by Gikas, Panagiotis D, Hanna, Sammy A, Aston, Will, Kalson, Nicholas S, Tirabosco, Roberto, Saifuddin, Asif, Cannon, Steve R

“…Post-radiation peripheral neuropathy has been reported in brachial and cervical plexuses and the femoral nerve. We describe a patient who developed…”
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A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty by Dixon, David, Coates, Jonathon, del Carpio Pons, Alicia, Horabin, Joanna, Walker, Andrew, Abdul, Nicole, Kalson, Nicholas S., Brewster, Nigel T., Weir, David J., Deehan, David J., Mann, Derek A., Borthwick, Lee A.

“…Arthrofibrosis is a fibroproliferative disease characterised by excessive deposition of extracellular matrix components intra-articularly leading to pain and…”
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Tenocyte contraction induces crimp formation in tendon-like tissue by Herchenhan, Andreas, Kalson, Nicholas S., Holmes, David F., Hill, Patrick, Kadler, Karl E., Margetts, Lee

“…Tendons are composed of longitudinally aligned collagen fibrils arranged in bundles with an undulating pattern, called crimp. The crimp structure is…”
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UK High Altitude Research: A report from the Birmingham Medical Research Expeditionary Society (BMRES) Altitude Research Conference, December 4, 2009, held at the Birmingham Medical Institute, United Kingdom by Kalson, Nicholas S., BSc (Hons), Stubbings, Alison H, Collins, Hannah L., MBChB, MRCS, Pattinson, Kyle T.S., BM, DPhil, FRCA, Wright, Alexander D., MB, FRCP

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