Search Results - "Kalpage, Hasini A"

Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy by Carter, Jenna L., Hege, Katie, Yang, Jay, Kalpage, Hasini A., Su, Yongwei, Edwards, Holly, Hüttemann, Maik, Taub, Jeffrey W., Ge, Yubin

“…Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common form of acute leukemia in children. Despite this,…”
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Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle by Morse, Paul T., Pérez-Mejías, Gonzalo, Wan, Junmei, Turner, Alice A., Márquez, Inmaculada, Kalpage, Hasini A., Vaishnav, Asmita, Zurek, Matthew P., Huettemann, Philipp P., Kim, Katherine, Arroum, Tasnim, De la Rosa, Miguel A., Chowdhury, Dipanwita Dutta, Lee, Icksoo, Brunzelle, Joseph S., Sanderson, Thomas H., Malek, Moh H., Meierhofer, David, Edwards, Brian F. P., Díaz-Moreno, Irene, Hüttemann, Maik

“…Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational modifications of cytochrome c (Cyt c )…”
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Prostate Cancer-Specific Lysine 53 Acetylation of Cytochrome c Drives Metabolic Reprogramming and Protects from Apoptosis in Intact Cells by Morse, Paul T, Wan, Junmei, Arroum, Tasnim, Herroon, Mackenzie K, Kalpage, Hasini A, Bazylianska, Viktoriia, Lee, Icksoo, Heath, Elisabeth I, Podgorski, Izabela, Hüttemann, Maik

“…Cytochrome (Cyt ) is important for both mitochondrial respiration and apoptosis, both of which are altered in cancer cells that switch to Warburg metabolism…”
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Brain-Specific Serine-47 Modification of Cytochrome c Regulates Cytochrome c Oxidase Activity Attenuating ROS Production and Cell Death: Implications for Ischemia/Reperfusion Injury and Akt Signaling by Kalpage, Hasini A, Wan, Junmei, Morse, Paul T, Lee, Icksoo, Hüttemann, Maik

“…We previously reported that serine-47 (S47) phosphorylation of cytochrome (Cyt ) in the brain results in lower cytochrome oxidase (COX) activity and caspase-3…”
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Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis by Bazylianska, Viktoriia, Kalpage, Hasini A, Wan, Junmei, Vaishnav, Asmita, Mahapatra, Gargi, Turner, Alice A, Chowdhury, Dipanwita Dutta, Kim, Katherine, Morse, Paul T, Lee, Icksoo, Brunzelle, Joseph S, Polin, Lisa, Subedi, Prabal, Heath, Elisabeth I, Podgorski, Izabela, Marcus, Katrin, Edwards, Brian F P, Hüttemann, Maik

“…Prostate cancer is the second leading cause of cancer-related death in men. Two classic cancer hallmarks are a metabolic switch from oxidative phosphorylation…”
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Tissue‐specific regulation of cytochrome c by post‐translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis by Kalpage, Hasini A., Bazylianska, Viktoriia, Recanati, Maurice A., Fite, Alemu, Liu, Jenney, Wan, Junmei, Mantena, Nikhil, Malek, Moh H., Podgorski, Izabela, Heath, Elizabeth I., Vaishnav, Asmita, Edwards, Brian F., Grossman, Lawrence I., Sanderson, Thomas H., Lee, Icksoo, Huttemann, Maik

“…ABSTRACT Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In addition, it is a key regulator of apoptosis. Cytc has…”
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Targeting mitochondrial respiration for the treatment of acute myeloid leukemia by Carter, Jenna L., Hege, Katie, Kalpage, Hasini A., Edwards, Holly, Hüttemann, Maik, Taub, Jeffrey W., Ge, Yubin

“…[Display omitted] Acute myeloid leukemia (AML) is a heterogeneous disease with variable presentation, molecular phenotype, and cytogenetic abnormalities and…”
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Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis by Kalpage, Hasini A., Wan, Junmei, Morse, Paul T., Zurek, Matthew P., Turner, Alice A., Khobeir, Antoine, Yazdi, Nabil, Hakim, Lara, Liu, Jenney, Vaishnav, Asmita, Sanderson, Thomas H., Recanati, Maurice-Andre, Grossman, Lawrence I., Lee, Icksoo, Edwards, Brian F.P., Hüttemann, Maik

“…Cytochrome c (Cytc)1is a cellular life and death decision molecule that regulates cellular energy supply and apoptosis through tissue specific…”
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A Study on Hereditary Thrombophilia and Stroke in a Cohort from Sri Lanka by Kalpage, Hasini A., PhD, Sumathipala, Dulika S., MBBS, MSc, Goonasekara, Hemali W., MBBS, MD, Dissanayake, Vajira H., MBBS, PhD

“…Background Thrombophilia is an enhanced tendency of arterial or venous blood clot formation. The frequently assessed hereditary thrombophilia mutations…”
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Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis by LaMoia, Traci E, Butrico, Gina M, Kalpage, Hasini A, Goedeke, Leigh, Hubbard, Brandon T, Vatner, Daniel F, Gaspar, Rafael C, Zhang, Xian-Man, Cline, Gary W, Nakahara, Keita, Woo, Seungwan, Shimada, Atsuhiro, Hüttemann, Maik, Shulman, Gerald I

“…SignificanceMetformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus, yet the mechanism by which it lowers plasma glucose…”
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Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia by Hege Hurrish, Katie, Qiao, Xinan, Li, Xinyu, Su, Yongwei, Carter, Jenna, Ma, Jun, Kalpage, Hasini A., Hüttemann, Maik, Edwards, Holly, Wang, Guan, Kim, Seongho, Dombkowski, Alan, Bao, Xun, Li, Jing, Taub, Jeffrey W., Ge, Yubin

“…[Display omitted] Despite the recently approved new therapies, the clinical outcomes of acute myeloid leukemia (AML) patients remain disappointing,…”
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Regulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation by Wan, Junmei, Kalpage, Hasini A., Vaishnav, Asmita, Liu, Jenney, Lee, Icksoo, Mahapatra, Gargi, Turner, Alice A., Zurek, Matthew P., Ji, Qinqin, Moraes, Carlos T., Recanati, Maurice-Andre, Grossman, Lawrence I., Salomon, Arthur R., Edwards, Brian F. P., Hüttemann, Maik

“…Cytochrome c (Cyt c ) is a multifunctional protein, acting as an electron carrier in the electron transport chain (ETC), where it shuttles electrons from bc 1…”
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Serine‐47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase‐3 activity by Kalpage, Hasini A., Vaishnav, Asmita, Liu, Jenney, Varughese, Ashwathy, Wan, Junmei, Turner, Alice A., Ji, Qinqin, Zurek, Matthew P., Kapralov, Alexandr A., Kagan, Valerian E., Brunzelle, Joseph S., Recanati, Maurice‐Andre, Grossman, Lawrence I., Sanderson, Thomas H., Lee, Icksoo, Salomon, Arthur R., Edwards, Brian F. P., Hüttemann, Maik

“…Cytochrome c (Cytc) is a multifunctional protein that operates as an electron carrier in the mitochondrial electron transport chain and plays a key role in…”
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Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation by Liu, Fangbing, Kalpage, Hasini A., Wang, Deying, Edwards, Holly, Hüttemann, Maik, Ma, Jun, Su, Yongwei, Carter, Jenna, Li, Xinyu, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H., White, Kathryn, Wang, Guan, Taub, Jeffrey W., Ge, Yubin

“…Targeting oxidative phosphorylation (OXPHOS) is a promising strategy to improve treatment outcomes of acute myeloid leukemia (AML) patients. IACS-010759 is a…”
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Serine‐47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase‐3 activity by Kalpage, Hasini A., Vaishnav, Asmita, Liu, Jenney, Varughese, Ashwathy, Wan, Junmei, Turner, Alice A., Ji, Qinqin, Zurek, Matthew P., Kapralov, Alexandr A., Kagan, Valerian E., Brunzelle, Joseph S., Recanati, Maurice‐Andre, Grossman, Lawrence I., Sanderson, Thomas H., Lee, Icksoo, Salomon, Arthur R., Edwards, Brian F. P., Hüttemann, Maik

“…Cytochrome c (Cyt c ) is a multifunctional protein that operates as an electron carrier in the mitochondrial electron transport chain and plays a key role in…”
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