Search Results - "Kalousi, Alkmini"

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin by Kalousi, Alkmini, Hoffbeck, Anne-Sophie, Selemenakis, Platonas N., Pinder, Jordan, Savage, Kienan I., Khanna, Kum Kum, Brino, Laurent, Dellaire, Graham, Gorgoulis, Vassilis G., Soutoglou, Evi

“…Cells experience damage from exogenous and endogenous sources that endanger genome stability. Several cellular pathways have evolved to detect DNA damage and…”
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Casein kinase 1 regulates human hypoxia-inducible factor HIF-1 by Kalousi, Alkmini, Mylonis, Ilias, Politou, Anastasia S, Chachami, Georgia, Paraskeva, Efrosyni, Simos, George

“…Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response to hypoxia and a promising target of anticancer therapy, is…”
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Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs by Nagy, Zita, Kalousi, Alkmini, Furst, Audrey, Koch, Marc, Fischer, Benoit, Soutoglou, Evi

“…DNA lesions are sensed by a network of proteins that trigger the DNA damage response (DDR), a signaling cascade that acts to delay cell cycle progression and…”
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An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis by Chachami, Georgia, Kalousi, Alkmini, Papatheodorou, Loukia, Lyberopoulou, Aggeliki, Nasikas, Vasileios, Tanimoto, Keiji, Simos, George, Malizos, Konstantinos N, Georgatsou, Eleni

“…Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if…”
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Nuclear compartmentalization of DNA repair by Kalousi, Alkmini, Soutoglou, Evi

“…The continuous threats on genome integrity by endogenous and exogenous sources have rendered cells competent to overcome these challenges by activating DNA…”
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TIRR regulates 53BP1 by masking its histone methyl-lysine binding function by Drané, Pascal, Brault, Marie-Eve, Cui, Gaofeng, Meghani, Khyati, Chaubey, Shweta, Detappe, Alexandre, Parnandi, Nishita, He, Yizhou, Zheng, Xiao-Feng, Botuyan, Maria Victoria, Kalousi, Alkmini, Yewdell, William T., Münch, Christian, Harper, J. Wade, Chaudhuri, Jayanta, Soutoglou, Evi, Mer, Georges, Chowdhury, Dipanjan

“…P53-binding protein 1 (53BP1) is a multi-functional double-strand break repair protein that is essential for class switch recombination in B lymphocytes and…”
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Identification of MAPK Phosphorylation Sites and Their Role in the Localization and Activity of Hypoxia-inducible Factor-1α by Mylonis, Ilias, Chachami, Georgia, Samiotaki, Martina, Panayotou, George, Paraskeva, Efrosini, Kalousi, Alkmini, Georgatsou, Eleni, Bonanou, Sofia, Simos, George

“…Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible…”
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Minimized combinatorial CRISPR screens identify genetic interactions in autophagy by Diehl, Valentina, Wegner, Martin, Grumati, Paolo, Husnjak, Koraljka, Schaubeck, Simone, Gubas, Andrea, Shah, Varun Jayeshkumar, Polat, Ibrahim H, Langschied, Felix, Prieto-Garcia, Cristian, Müller, Konstantin, Kalousi, Alkmini, Ebersberger, Ingo, Brandts, Christian H, Dikic, Ivan, Kaulich, Manuel

“…Abstract Combinatorial CRISPR-Cas screens have advanced the mapping of genetic interactions, but their experimental scale limits the number of targetable gene…”
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A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair by Shahar, Or David, Kalousi, Alkmini, Eini, Lital, Fisher, Benoit, Weiss, Amelie, Darr, Jonatan, Mazina, Olga, Bramson, Shay, Kupiec, Martin, Eden, Amir, Meshorer, Eran, Mazin, Alexander V., Brino, Laurent, Goldberg, Michal, Soutoglou, Evi

“…DNA double-strand breaks (DSBs) are the most severe type of DNA damage. DSBs are repaired by non-homologous end-joining or homology directed repair (HDR)…”
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Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs: e1005791 by Nagy, Zita, Kalousi, Alkmini, Furst, Audrey, Koch, Marc, Fischer, Benoit, Soutoglou, Evi

“…DNA lesions are sensed by a network of proteins that trigger the DNA damage response (DDR), a signaling cascade that acts to delay cell cycle progression and…”
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Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera by Chachami, Georgia, Lyberopoulou, Aggeliki, Kalousi, Alkmini, Paraskeva, Efrosyni, Pantopoulos, Kostas, Simos, George

“…•GFP was fused to hepcidin C-terminus and the chimera was expressed in Huh7 cells.•Stable low expression led to secretion of a properly matured…”
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MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization by Lyberopoulou, Aggeliki, Mylonis, Ilias, Papachristos, George, Sagris, Dimitrios, Kalousi, Alkmini, Befani, Christina, Liakos, Panagiotis, Simos, George, Georgatsou, Eleni

“…Hypoxia inducible factor-1 (HIF-1), a dimeric transcription factor of the bHLH-PAS family, is comprised of HIF-1α, which is inducible by hypoxia and ARNT or…”
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An Association Study between Hypoxia Inducible Factor-1alpha by Chachami, Georgia, Kalousi, Alkmini, Papatheodorou, Loukia, Lyberopoulou, Aggeliki, Nasikas, Vasileios, Tanimoto, Keiji, Simos, George, Malizos, Konstantinos N, Georgatsou, Eleni

“…Bone hypoxia resulting from impaired blood flow is the final pathway for the development of osteonecrosis (ON). The aim of this study was to evaluate if…”
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Reconstitution of human hypoxia inducible factor HIF-1 in yeast: A simple in vivo system to identify and characterize HIF-1α effectors by Braliou, Georgia G., Venieris, Emmanouil, Kalousi, Alkmini, Simos, George

“…Hypoxia inducible factor 1 (HIF-1), the master regulator of hypoxia-activated genes, is involved in many diseases and is a valid drug target. In order to…”
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Reconstitution of human hypoxia inducible factor HIF-1 in yeast: a simple in vivo system to identify and characterize HIF-1alpha effectors by Braliou, Georgia G, Venieris, Emmanouil, Kalousi, Alkmini, Simos, George

“…Hypoxia inducible factor 1 (HIF-1), the master regulator of hypoxia-activated genes, is involved in many diseases and is a valid drug target. In order to…”
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Identification of MAPK Phosphorylation Sites and Their Role in the Localization and Activity of Hypoxia-inducible Factor-1Î by Ilias Mylonis, Georgia Chachami, Martina Samiotaki, George Panayotou, Efrosini Paraskeva, Alkmini Kalousi, Eleni Georgatsou, Sofia Bonanou, George Simos

“…Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible…”
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Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha by Mylonis, Ilias, Chachami, Georgia, Samiotaki, Martina, Panayotou, George, Paraskeva, Efrosini, Kalousi, Alkmini, Georgatsou, Eleni, Bonanou, Sofia, Simos, George

“…Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible…”
Get full text