Search Results - "Kalodimos, Charalampos G."

Structural basis for client recognition and activity of Hsp40 chaperones by Jiang, Yajun, Rossi, Paolo, Kalodimos, Charalampos G

“…Hsp70 and Hsp40 chaperones work synergistically in a wide range of biological processes including protein synthesis, membrane translocation, and folding. We…”
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Protein activity regulation by conformational entropy by Tzeng, Shiou-Ru, Kalodimos, Charalampos G.

“…Some variants of the bacterial gene regulator CAP show marked differences in their affinity for DNA despite identical DNA-binding interfaces; NMR spectroscopy…”
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Structural Basis for Protein Antiaggregation Activity of the Trigger Factor Chaperone by Saio, Tomohide, Guan, Xiao, Rossi, Paolo, Economou, Anastassios, Kalodimos, Charalampos G.

“…Molecular chaperones prevent aggregation and misfolding of proteins, but scarcity of structural data has impeded an understanding of the recognition and…”
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Structures of Large Protein Complexes Determined by Nuclear Magnetic Resonance Spectroscopy by Huang, Chengdong, Kalodimos, Charalampos G

“…Nuclear magnetic resonance (NMR) spectroscopy has been instrumental during the past two decades in providing high-resolution structures of protein complexes…”
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Structural basis for the antifolding activity of a molecular chaperone by Huang, Chengdong, Rossi, Paolo, Saio, Tomohide, Kalodimos, Charalampos G.

“…Molecular chaperones act on non-native proteins in the cell to prevent their aggregation, premature folding or misfolding. Different chaperones often exert…”
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Dynamic activation of an allosteric regulatory protein by Kalodimos, Charalampos G, Tzeng, Shiou-Ru

“…Allosteric regulation is used as a very efficient mechanism to control protein activity in most biological processes, including signal transduction,…”
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Atomic view of the energy landscape in the allosteric regulation of Abl kinase by Saleh, Tamjeed, Rossi, Paolo, Kalodimos, Charalampos G

“…NMR spectroscopy analyses of the Abl regulatory module (RM), which tunes Abl kinase activity, explain the mechanism of certain RM-located drug-resistance…”
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Structures of chaperone-substrate complexes docked onto the export gate in a type III secretion system by Xing, Qiong, Shi, Ke, Portaliou, Athina, Rossi, Paolo, Economou, Anastassios, Kalodimos, Charalampos G.

“…The flagellum and the injectisome enable bacterial locomotion and pathogenesis, respectively. These nanomachines assemble and function using a type III…”
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Allosteric inhibition through suppression of transient conformational states by Tzeng, Shiou-Ru, Kalodimos, Charalampos G

“…Advanced NMR studies of catabolite activator protein show that allosteric inhibitors can prevent conformational changes needed for a protein to bind its…”
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NMR reveals novel mechanisms of protein activity regulation by Kalodimos, Charalampos G.

“…NMR spectroscopy is one of the most powerful tools for the characterization of biomolecular systems. A unique aspect of NMR is its capacity to provide an…”
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Oligomerization of a molecular chaperone modulates its activity by Saio, Tomohide, Kawagoe, Soichiro, Ishimori, Koichiro, Kalodimos, Charalampos G

“…Molecular chaperones alter the folding properties of cellular proteins via mechanisms that are not well understood. Here, we show that Trigger Factor (TF), an…”
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Structural basis for cAMP-mediated allosteric control of the catabolite activator protein by Popovych, Nataliya, Tzeng, Shiou-Ru, Tonelli, Marco, Ebright, Richard H, Kalodimos, Charalampos G

“…The cAMP-mediated allosteric transition in the catabolite activator protein (CAP; also known as the cAMP receptor protein, CRP) is a textbook example of…”
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Recognition and targeting mechanisms by chaperones in flagellum assembly and operation by Khanra, Nandish, Rossi, Paolo, Economou, Anastassios, Kalodimos, Charalampos G.

“…The flagellum is a complex bacterial nanomachine that requires the proper assembly of several different proteins for its function. Dedicated chaperones are…”
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Automatic methyl assignment in large proteins by the MAGIC algorithm by Monneau, Yoan R., Rossi, Paolo, Bhaumik, Anusarka, Huang, Chengdong, Jiang, Yajun, Saleh, Tamjeed, Xie, Tao, Xing, Qiong, Kalodimos, Charalampos G.

“…Selective methyl labeling is an extremely powerful approach to study the structure, dynamics and function of biomolecules by NMR. Despite spectacular progress…”
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Confirmation for conformational selection by Jiang, Yajun, Kalodimos, Charalampos G

“…NMR studies settle part of a long-standing debate about the mechanism used by the Hsp70 chaperone to recognize substrates…”
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Proline cis- trans Isomerization Controls Autoinhibition of a Signaling Protein by Sarkar, Paramita, Reichman, Charles, Saleh, Tamjeed, Birge, Raymond B., Kalodimos, Charalampos G.

“…Autoinhibition is being widely used in nature to repress otherwise constitutive protein activities and is typically regulated by extrinsic factors. Here we…”
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Structural basis for regulation of the Crk signaling protein by a proline switch by Kalodimos, Charalampos G, Sarkar, Paramita, Saleh, Tamjeed, Tzeng, Shiou-Ru, Birge, Raymond B

“…Structural analysis by NMR reveals that the Gly237-Pro238 bond of the signaling protein Crk in the cis form stabilizes an autoinhibited conformation between…”
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Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII by Jankowski, Wojciech, Saleh, Tamjeed, Pai, Ming-Tao, Sriram, Ganapathy, Birge, Raymond B, Kalodimos, Charalampos G

“…NMR structures of CrkL, an adaptor protein that mediates Bcr-Abl signaling in CML, reveal domain organization distinct from CrkII that allows constitutive…”
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Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes by Kalodimos, Charalampos G., Biris, Nikolaos, Alexandre M. J. J. Bonvin, Levandoski, Marc M., Guennuegues, Marc, Boelens, Rolf, Kaptein, Robert

“…Interaction of regulatory DNA binding proteins with their target sites is usually preceded by binding to nonspecific DNA. This speeds up the search for the…”
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Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions by Chen, Li, Balabanidou, Vassilia, Remeta, David P., Minetti, Conceição A.S.A., Portaliou, Athina G., Economou, Anastassios, Kalodimos, Charalampos G.

“…Protein-protein interactions mediate a vast number of cellular processes. Here, we present a regulatory mechanism in protein-protein interactions mediated by…”
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