Search Results - "Kallemeyn, Jeffrey M."

Development of an Enantioselective [3 + 2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale by Hartung, John, Greszler, Stephen N, Klix, Russell C, Kallemeyn, Jeffrey M

“…The tetrasubstituted pyrrolidine core of ABBV-3221 was synthesized by catalytic, enantioselective cycloaddition. A Cu­(I) catalyst system was identified as…”
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Synthesis of 3,4,5-Trisubstituted Isoxazoles via Sequential [3 + 2] Cycloaddition/Silicon-Based Cross-Coupling Reactions by Denmark, Scott E, Kallemeyn, Jeffrey M

“…A [3 + 2] cycloaddition reaction between alkynyldimethylsilyl ethers and aryl and alkyl nitrile oxides to produce isoxazolylsilanols has been developed. The…”
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Palladium-Catalyzed Silylation of Aryl Bromides Leading to Functionalized Aryldimethylsilanols by Denmark, Scott E, Kallemeyn, Jeffrey M

“…A mild and general palladium-catalyzed insertion of 1,2-diethoxy-1,1,2,2-tetramethyldisilane into a variety of aryl bromides affords the aryldimethylsilyl…”
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Development of the Enabling Route for Glecaprevir via Ring-Closing Metathesis by Cink, Russell D, Lukin, Kirill A, Bishop, Richard D, Zhao, Gang, Pelc, Matthew J, Towne, Timothy B, Gates, Bradley D, Ravn, Matthew M, Hill, David R, Ding, Chen, Cullen, Steven C, Mei, Jianzhang, Leanna, M. Robert, Henle, Jeremy, Napolitano, José G, Nere, Nandkishor K, Chen, Shuang, Sheikh, Ahmad, Kallemeyn, Jeffrey M

“…Glecaprevir was identified as a potent HCV NS3/4A protease inhibitor, and an enabling synthesis was required to support the preclinical evaluation and…”
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Stereospecific Palladium-Catalyzed Cross-Coupling of (E)- and (Z)-Alkenylsilanolates with Aryl Chlorides by Denmark, Scott E, Kallemeyn, Jeffrey M

“…The cross-coupling of geometrically defined (E)- and (Z)-alkenyl- and styrylsilanolates with a wide variety of aromatic and heteroaromatic chlorides has been…”
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Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification by Kallemeyn, Jeffrey M, Engstrom, Kenneth M, Pelc, Matthew J, Lukin, Kirill A, Morrill, Westin H, Wei, Haojuan, Towne, Timothy B, Henle, Jeremy, Nere, Nandkishor K, Welch, Dennie S, Shekhar, Shashank, Ravn, Matthew M, Zhao, Gang, Fickes, Michael G, Ding, Chen, Vinci, John C, Marren, James, Cink, Russell D

“…Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical…”
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A Kinetics-Based Approach for the Assignment of Reactivity Purge Factors by Betori, Rick C, Kallemeyn, Jeffrey M, Welch, Dennie S

“…The control of mutagenic impurities is of crucial interest to pharmaceutical companies and regulatory agencies alike. One risk-based methodology to assess the…”
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New Semi-Automated Computer-Based System for Assessing the Purge of Mutagenic Impurities by Burns, Michael J, Ott, Martin A, Teasdale, Andrew, Stalford, Susanne A, Antonucci, Vincent, Baumann, Jens-Christoph, Brown, Roland, Covey-Crump, Elizabeth M, Elder, David, Elliott, Eric, Fennell, Jared W, Gallou, Fabrice, Ide, Nathan D, Itoh, Tetsuji, Jordine, Guido, Kallemeyn, Jeffrey M, Lauwers, Dirk, Looker, Adam R, Lovelle, Lucie E, Molzahn, Robert, Schils, Didier, Schulte Oestrich, Rolf, Sluggett, Gregory W, Stevenson, Neil, Talavera, Pere, Urquhart, Michael W, Varie, David L, Welch, Dennie S

“…The ICH M7 guidance provides a series of flexible control options for the control of (potentially) mutagenic impurities (PMIs) that fully align with key…”
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A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategies by Barber, Chris, Antonucci, Vincent, Baumann, Jens-Christoph, Brown, Roland, Covey-Crump, Elizabeth, Elder, David, Elliott, Eric, Fennell, Jared W., Gallou, Fabrice, Ide, Nathan D., Jordine, Guido, Kallemeyn, Jeffrey M., Lauwers, Dirk, Looker, Adam R., Lovelle, Lucie E., McLaughlin, Mark, Molzahn, Robert, Ott, Martin, Schils, Didier, Oestrich, Rolf Schulte, Stevenson, Neil, Talavera, Pere, Teasdale, Andrew, Urquhart, Michael W., Varie, David L., Welch, Dennie

“…The ICH M7 Option 4 control of (potentially) mutagenic impurities is based on the use of scientific principles in lieu of routine analytical testing. This…”
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Scalable Synthesis of a Cis-Substituted Cyclobutyl-Benzothiazole Pyridazinone: Process Development of an Efficient Copper Catalyzed C–N Cross-Coupling Reaction by Kallemeyn, Jeffrey M, Ku, Yi-Yin, Mulhern, Mathew M, Bishop, Richard, Pal, Agnes, Jacob, Legi

“…A scalable process for the preparation of 2-(2-(cis-3-(piperidin-1-yl)cyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one in multi-kilogram amounts and in high…”
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The Development of Continuous Process for Alkene Ozonolysis Based on Combined in Situ FTIR, Calorimetry, and Computational Chemistry by Allian, Ayman D, Richter, Steve M, Kallemeyn, Jeffrey M, Robbins, Timothy A, Kishore, Vimal

“…Two continuous apparatuses were designed that are capable of safely scaling the highly energetic ozonolysis reaction to multikilogram scale where flow…”
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Improved Synthesis of 3-Substituted-4-amino-[3,2-c]-thienopyridines by Engstrom, Kenneth M, Baize, Amanda L, Franczyk, Thaddeus S, Kallemeyn, Jeffrey M, Mulhern, Mathew M, Rickert, Robert C, Wagaw, Seble

“…Two syntheses of 3-substituted-4-amino-[3,2-c]thienopyridines have been developed to replace the standard literature route to these compounds, which uses…”
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Photochemical Synthesis of 3-Alkynals from 1-Alkynoxy-9,10-anthraquinones by Blankespoor, Ronald L, Boldenow, Peter J, Hansen, Eric C, Kallemeyn, Jeffrey M, Lohse, Andrew G, Rubush, David M, Vrieze, Derek

“…Photolysis of 1-(3-alkynoxy)-9,10-anthraquinones in deoxygenated methanol leads to moderate yields (35−45%) of 3-alkynals along with the unexpected formation…”
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Photochemical Synthesis of Aldehydes in the Solid Phase by Blankespoor, Ronald L, DeVries, Tim, Hansen, Eric, Kallemeyn, Jeffrey M, Klooster, Aaron M, Mulder, Jason A, Smart, Robert P, Vander Griend, Douglas A

“…A substituted anthraquinone (AQ), previously shown to photochemically generate benzaldehyde in methanol solution, was attached to a commercially available…”
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Development of a Telescoped Alkylation/Reduction Reaction Sequence and an Asymmetric Hydrogenation to Enable the Kilogram Synthesis of ABBV-3748 by Kallemeyn, Jeffrey M., Hartung, John, Connolly, Timothy, Ickes, Andrew, Kotecki, Brian, Van Haandel, Leon, Nazari, Milad, Manjrekar, Onkar, Chen, Shuang

“…Challenges in the synthesis of the cystic fibrosis transmembrane receptor corrector ABBV-3748 were addressed to enable a multikilogram-scale GMP sequence…”
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Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation by Lathrop, Stephen P., Mlinar, Laurie B., Manjrekar, Onkar N., Zhou, Yong, Harper, Kaid C., Sacia, Eric R., Higgins, Molly, Bogdan, Andrew R., Wang, Zhe, Richter, Steven M., Gong, Wei, Voight, Eric A., Henle, Jeremy, Diwan, Moiz, Kallemeyn, Jeffrey M., Sharland, Jack C., Wei, Bo, Davies, Huw M. L.

“…We report the development and demonstration of a continuous-flow process for the safe formation, extraction, and drying of aryldiazoacetate 2, which enables…”
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Establishing Best Practice for the Application and Support of Solubility Purge Factors by Burns, Michael J., Andrews, Ian X., Baumann, Jens-Christoph, Elliott, Eric L., Fennell, Jared W., Kallemeyn, Jeffrey M., Lemaire, Sebastien, Murphy, Natasha S., Palacio, Magali, Raw, Steven A., Roberts, Alastair J., Moura Rocha, Nayrton Flávio, Schils, Didier, Oestrich, Rolf Schulte, Shannon-Little, Andrew L., Stevenson, Neil, Talavera, Pere, Teasdale, Andrew, Urquhart, Michael W., Waechter, Fernanda

“…The increased usage of purge arguments for demonstrating control of mutagenic impurities in drug substances, in accordance with ICH M7, necessitates an…”
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Enhanced Approaches to the Identification, Evaluation, and Control of Impurities by Popkin, Matt E., Borman, Phil J., Omer, Batool Ahmed, Looker, Adam, Kallemeyn, Jeffrey M.

“…A series of case histories from IQ consortium member companies will be presented to exemplify how the application of the ICH Q11 vision for enhanced or quality…”
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Author Correction: Enhanced Approaches to the Identification, Evaluation, and Control of Impurities by Popkin, Matt E., Borman, Phil J., Omer, Batool Ahmed, Looker, Adam, Kallemeyn, Jeffrey M.

“…The original version of this article unfortunately contained a mistake. The authors in the author group were listed incorrectly. The correct author group of…”
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The Delivery of Flexibility from the Application of QbD to API Development by Popkin, Matt E., Borman, Phil J., Omer, Batool Ahmed, Seibert, Kevin D., Srivastava, Sushil, Lepore, John V., Hobson, Lindsay, Donaubauer, John, Curran, Timothy, Ide, Nathan, Tymonko, Steven, Looker, Adam, Kallemeyn, Jeffrey M.

“…This paper by IQ consortium member companies will describe how the application of the ICH Q11 vision for enhanced QbD development can lead to flexibility…”
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