Search Results - "Kalle, Christof von"

In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases by Biasco, Luca, Pellin, Danilo, Scala, Serena, Dionisio, Francesca, Basso-Ricci, Luca, Leonardelli, Lorena, Scaramuzza, Samantha, Baricordi, Cristina, Ferrua, Francesca, Cicalese, Maria Pia, Giannelli, Stefania, Neduva, Victor, Dow, David J., Schmidt, Manfred, Von Kalle, Christof, Roncarolo, Maria Grazia, Ciceri, Fabio, Vicard, Paola, Wit, Ernst, Di Serio, Clelia, Naldini, Luigi, Aiuti, Alessandro

“…Hematopoietic stem/progenitor cells (HSPCs) are capable of supporting the lifelong production of blood cells exerting a wide spectrum of functions. Lentiviral…”
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BRAF Inhibition in Refractory Hairy-Cell Leukemia by Dietrich, Sascha, Glimm, Hanno, Andrulis, Mindaugas, von Kalle, Christof, Ho, Anthony D, Zenz, Thorsten

“…The authors report a dramatic response to vemurafenib in a patient with hairy-cell leukemia refractory to nucleosides and rituximab. To the Editor: Hairy-cell…”
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Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases by Dieter, Sebastian M., Ball, Claudia R., Hoffmann, Christopher M., Nowrouzi, Ali, Herbst, Friederike, Zavidij, Oksana, Abel, Ulrich, Arens, Anne, Weichert, Wilko, Brand, Karsten, Koch, Moritz, Weitz, Jürgen, Schmidt, Manfred, von Kalle, Christof, Glimm, Hanno

“…Human colon cancer harbors a small subfraction of tumor-initiating cells (TICs) that is assumed to be a functionally homogeneous stem-cell-like population…”
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Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector by Gaspar, H Bobby, Parsley, Kathryn L, Howe, Steven, King, Doug, Gilmour, Kimberly C, Sinclair, Joanna, Brouns, Gaby, Schmidt, Manfred, Von Kalle, Christof, Barington, Torben, Jakobsen, Marianne A, Christensen, Hans O, Al Ghonaium, Abdulaziz, White, Harry N, Smith, John L, Levinsky, Roland J, Ali, Robin R, Kinnon, Christine, Thrasher, Adrian J

“…X-linked severe combined immunodeficiency (SCID-X1) is caused by mutations in the common cytokine-receptor γchain(γc), resulting in disruption of development…”
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A Dermatologist's Ammunition in the War Against Smoking: A Photoaging App by Brinker, Titus Josef, Enk, Alexander, Gatzka, Martina, Nakamura, Yasuhiro, Sondermann, Wiebke, Omlor, Albert Joachim, Petri, Maximilian Philip, Karoglan, Ante, Seeger, Werner, Klode, Joachim, von Kalle, Christof, Schadendorf, Dirk

“…This viewpoint reviews the perspectives for dermatology as a specialty to go beyond the substantial impact of smoking on skin disease and leverage the impact…”
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Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy by Deichmann, Annette, Hacein-Bey-Abina, Salima, Schmidt, Manfred, Garrigue, Alexandrine, Brugman, Martijn H, Hu, Jingqiong, Glimm, Hanno, Gyapay, Gabor, Prum, Bernard, Fraser, Christopher C, Fischer, Nicolas, Schwarzwaelder, Kerstin, Siegler, Maria-Luise, de Ridder, Dick, Pike-Overzet, Karin, Howe, Steven J, Thrasher, Adrian J, Wagemaker, Gerard, Abel, Ulrich, Staal, Frank J T, Delabesse, Eric, Villeval, Jean-Luc, Aronow, Bruce, Hue, Christophe, Prinz, Claudia, Wissler, Manuela, Klanke, Chuck, Weissenbach, Jean, Alexander, Ian, Fischer, Alain, von Kalle, Christof, Cavazzana-Calvo, Marina

“…Recent reports have challenged the notion that retroviruses and retroviral vectors integrate randomly into the host genome. These reports pointed to a strong…”
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Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells by Hematti, Peiman, Hong, Bum-Kee, Ferguson, Cole, Adler, Rima, Hanawa, Hideki, Sellers, Stephanie, Holt, Ingeborg E, Eckfeldt, Craig E, Sharma, Yugal, Schmidt, Manfred, von Kalle, Christof, Persons, Derek A, Billings, Eric M, Verfaillie, Catherine M, Nienhuis, Arthur W, Wolfsberg, Tyra G, Dunbar, Cynthia E, Calmels, Boris

“…Murine leukemia virus (MLV)-derived vectors are widely used for hematopoietic stem cell (HSC) gene transfer, but lentiviral vectors such as the simian…”
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Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review by Brinker, Titus Josef, Hekler, Achim, Utikal, Jochen Sven, Grabe, Niels, Schadendorf, Dirk, Klode, Joachim, Berking, Carola, Steeb, Theresa, Enk, Alexander H, von Kalle, Christof

“…State-of-the-art classifiers based on convolutional neural networks (CNNs) were shown to classify images of skin cancer on par with dermatologists and could…”
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Stem Cell Collection and Gene Transfer in Fanconi Anemia by Kelly, Patrick F, Radtke, Susan, Kalle, Christof von, Balcik, Brenden, Bohn, Kimberley, Mueller, Robin, Schuesler, Todd, Haren, Moira, Reeves, Lilith, Cancelas, Jose A, Leemhuis, Thomas, Harris, Richard, Auerbach, Arleen D, Smith, Franklin O, Davies, Stella M, Williams, David A

“…Fanconi anemia (FA) is a rare genetic syndrome characterized by progressive bone marrow failure (BMF), congenital anomalies, and a predisposition to…”
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COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis by Chua, Robert Lorenz, Lukassen, Soeren, Trump, Saskia, Hennig, Bianca P., Wendisch, Daniel, Pott, Fabian, Debnath, Olivia, Thürmann, Loreen, Kurth, Florian, Völker, Maria Theresa, Kazmierski, Julia, Timmermann, Bernd, Twardziok, Sven, Schneider, Stefan, Machleidt, Felix, Müller-Redetzky, Holger, Maier, Melanie, Krannich, Alexander, Schmidt, Sein, Balzer, Felix, Liebig, Johannes, Loske, Jennifer, Suttorp, Norbert, Eils, Jürgen, Ishaque, Naveed, Liebert, Uwe Gerd, von Kalle, Christof, Hocke, Andreas, Witzenrath, Martin, Goffinet, Christine, Drosten, Christian, Laudi, Sven, Lehmann, Irina, Conrad, Christian, Sander, Leif-Erik, Eils, Roland

“…To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on…”
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Retroviral vectors: post entry events and genomic alterations by Nowrouzi, Ali, Glimm, Hanno, von Kalle, Christof, Schmidt, Manfred

“…The curative potential of retroviral vectors for somatic gene therapy has been demonstrated impressively in several clinical trials leading to sustained…”
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Deep learning outperformed 11 pathologists in the classification of histopathological melanoma images by Hekler, Achim, Utikal, Jochen S., Enk, Alexander H., Solass, Wiebke, Schmitt, Max, Klode, Joachim, Schadendorf, Dirk, Sondermann, Wiebke, Franklin, Cindy, Bestvater, Felix, Flaig, Michael J., Krahl, Dieter, von Kalle, Christof, Fröhling, Stefan, Brinker, Titus J.

“…The diagnosis of most cancers is made by a board-certified pathologist based on a tissue biopsy under the microscope. Recent research reveals a high…”
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Targeted BiTE Expression by an Oncolytic Vector Augments Therapeutic Efficacy Against Solid Tumors by Speck, Tobias, Heidbuechel, Johannes P W, Veinalde, Rūta, Jaeger, Dirk, von Kalle, Christof, Ball, Claudia R, Ungerechts, Guy, Engeland, Christine E

“…Immunotherapy with bispecific T-cell engagers has achieved striking success against hematologic malignancies, but efficacy against solid tumors has been…”
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Comparing artificial intelligence algorithms to 157 German dermatologists: the melanoma classification benchmark by Brinker, Titus J., Hekler, Achim, Hauschild, Axel, Berking, Carola, Schilling, Bastian, Enk, Alexander H., Haferkamp, Sebastian, Karoglan, Ante, von Kalle, Christof, Weichenthal, Michael, Sattler, Elke, Schadendorf, Dirk, Gaiser, Maria R., Klode, Joachim, Utikal, Jochen S.

“…Several recent publications have demonstrated the use of convolutional neural networks to classify images of melanoma at par with board-certified…”
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Deep learning approach to predict lymph node metastasis directly from primary tumour histology in prostate cancer by Wessels, Frederik, Schmitt, Max, Krieghoff‐Henning, Eva, Jutzi, Tanja, Worst, Thomas S., Waldbillig, Frank, Neuberger, Manuel, Maron, Roman C., Steeg, Matthias, Gaiser, Timo, Hekler, Achim, Utikal, Jochen S., Kalle, Christof, Fröhling, Stefan, Michel, Maurice S., Nuhn, Philipp, Brinker, Titus J.

“…Objective To develop a new digital biomarker based on the analysis of primary tumour tissue by a convolutional neural network (CNN) to predict lymph node…”
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Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing by Hovestadt, Volker, Jones, David T. W., Picelli, Simone, Wang, Wei, Kool, Marcel, Northcott, Paul A., Sultan, Marc, Stachurski, Katharina, Ryzhova, Marina, Warnatz, Hans-Jörg, Ralser, Meryem, Brun, Sonja, Bunt, Jens, Jäger, Natalie, Kleinheinz, Kortine, Erkek, Serap, Weber, Ursula D., Bartholomae, Cynthia C., von Kalle, Christof, Lawerenz, Chris, Eils, Jürgen, Koster, Jan, Versteeg, Rogier, Milde, Till, Witt, Olaf, Schmidt, Sabine, Wolf, Stephan, Pietsch, Torsten, Rutkowski, Stefan, Scheurlen, Wolfram, Taylor, Michael D., Brors, Benedikt, Felsberg, Jörg, Reifenberger, Guido, Borkhardt, Arndt, Lehrach, Hans, Wechsler-Reya, Robert J., Eils, Roland, Yaspo, Marie-Laure, Landgraf, Pablo, Korshunov, Andrey, Zapatka, Marc, Radlwimmer, Bernhard, Pfister, Stefan M., Lichter, Peter

“…Medulloblastoma is a malignant childhood brain tumour presenting major clinical challenges; here, a comprehensive genome-wide DNA methylation data set from…”
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A benchmark for neural network robustness in skin cancer classification by Maron, Roman C., Schlager, Justin G., Haggenmüller, Sarah, von Kalle, Christof, Utikal, Jochen S., Meier, Friedegund, Gellrich, Frank F., Hobelsberger, Sarah, Hauschild, Axel, French, Lars, Heinzerling, Lucie, Schlaak, Max, Ghoreschi, Kamran, Hilke, Franz J., Poch, Gabriela, Heppt, Markus V., Berking, Carola, Haferkamp, Sebastian, Sondermann, Wiebke, Schadendorf, Dirk, Schilling, Bastian, Goebeler, Matthias, Krieghoff-Henning, Eva, Hekler, Achim, Fröhling, Stefan, Lipka, Daniel B., Kather, Jakob N., Brinker, Titus J.

“…One prominent application for deep learning–based classifiers is skin cancer classification on dermoscopic images. However, classifier evaluation is often…”
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The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy by Montini, Eugenio, Cesana, Daniela, Schmidt, Manfred, Sanvito, Francesca, Bartholomae, Cynthia C, Ranzani, Marco, Benedicenti, Fabrizio, Sergi, Lucia Sergi, Ambrosi, Alessandro, Ponzoni, Maurilio, Doglioni, Claudio, Di Serio, Clelia, von Kalle, Christof, Naldini, Luigi

“…gamma-Retroviral vectors (gammaRVs), which are commonly used in gene therapy, can trigger oncogenesis by insertional mutagenesis. Here, we have dissected the…”
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Real-time definition of non-randomness in the distribution of genomic events by Abel, Ulrich, Deichmann, Annette, Bartholomae, Cynthia, Schwarzwaelder, Kerstin, Glimm, Hanno, Howe, Steven, Thrasher, Adrian, Garrigue, Alexandrine, Hacein-Bey-Abina, Salima, Cavazzana-Calvo, Marina, Fischer, Alain, Jaeger, Dirk, von Kalle, Christof, Schmidt, Manfred

“…Features such as mutations or structural characteristics can be non-randomly or non-uniformly distributed within a genome. So far, computer simulations were…”
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The German Corona Consensus Dataset (GECCO): a standardized dataset for COVID-19 research in university medicine and beyond by Sass, Julian, Bartschke, Alexander, Lehne, Moritz, Essenwanger, Andrea, Rinaldi, Eugenia, Rudolph, Stefanie, Heitmann, Kai U, Vehreschild, Jörg J, von Kalle, Christof, Thun, Sylvia

“…The current COVID-19 pandemic has led to a surge of research activity. While this research provides important insights, the multitude of studies results in an…”
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