Search Results - "Kalland, T"

Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A by Abrahmsén, L., Dohlsten, M., Segrén, S., Björk, P., Jonsson, E., Kalland, T.

“…Bacterial superantigens (SAgs) are potent activators of T lymphocytes and play a pathophysiological role in Gram‐positive septic shock and food poisoning. To…”
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Crystal structure of the superantigen staphylococcal enterotoxin type A by Schad, E.M., Zaitseva, I., Zaitsev, V.N., Dohlsten, M., Kalland, T., Schlievert, P.M., Ohlendorf, D.H., Svensson, L.A.

“…Staphylococcal enterotoxins are prototype superantigens characterized by their ability to bind to major histocompatibility complex (MHC) class II molecules and…”
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In vivo Anergized CD4+ T Cells Express Perturbed AP-1 and NF-κ B Transcription Factors by Sundstedt, Anette, Sigvardsson, Mikael, Leanderson, Tomas, Hedlund, Gunnar, Kalland, Terje, Dohlsten, Mikael

“…Anergy is a major mechanism to ensure antigen-specific tolerance in T lymphocytes in the adult. In vivo, anergy has mainly been studied at the cellular level…”
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Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer by Giantonio, B J, Alpaugh, R K, Schultz, J, McAleer, C, Newton, D W, Shannon, B, Guedez, Y, Kotb, M, Vitek, L, Persson, R, Gunnarsson, P O, Kalland, T, Dohlsten, M, Persson, B, Weiner, L M

“…To establish the maximum-tolerated dose (MTD) and define the toxicities of a single-dose infusion of PNU-214565, a recombinant Escherichia coli-derived fusion…”
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Treatment of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis with the Synthetic Immunomodulator Linomide (Quinoline-3-Carboxamide) by Karussis, Dimitrios M., Lehmann, Dan, Slavin, Shimon, Vourka-Karussis, Urania, Mizrachi-Koll, Rachel, Ovadia, Haim, Kalland, Terje, Abramsky, Oded

“…Linomide is a synthetic immunomodulator that enhances natural killer cell activity and significantly activates several lymphocytic cell subpopulations in both…”
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Antibody-Targeted Superantigens are Potent Inducers of Tumor-Infiltrating T Lymphocytes in vivo by Dohlsten, Mikael, Hansson, Johan, Ohlsson, Lennart, Litton, Mark, Kalland, Terje

“…Recruitment of antigen-specific tumorinfiltrating lymphocytes (TILs) is a major goal for immunotherapy of malignant tumors. We now describe that…”
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T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles by Wingren, A G, Parra, E, Varga, M, Kalland, T, Sjögren, H O, Hedlund, G, Dohlsten, M

“…Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC…”
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Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug by GROSS, D. J, SIDI, H, WEISS, L, KALLAND, T, ROSENMANN, E, SLAVIN, S

“…Oral administration of the synthetic immunomodulating drug quinoline-3-carboxamide (Linomide) in the drinking water to 5-week-old female non-obese diabetic…”
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Inhibition of acute, experimental autoimmune encephalomyelitis by the synthetic immunomodulator linomide by Karussis, D M, Lehmann, D, Slavin, S, Vourka-Karussis, U, Mizrachi-Koll, R, Ovadia, H, Ben-Nun, A, Kalland, T, Abramsky, O

“…Linomide (LS-2616, quinoline-3-carboxamide) is a synthetic immunomodulator that stimulates natural killer cell activity and activates several lymphocytic…”
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Interleukin 3 is a major negative regulator of the generation of natural killer cells from bone marrow precursors by Kalland, T

“…We have established a bone marrow culture system in which mature natural killer (NK) cells can be generated from inactive precursors by interleukin 2…”
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Generation of natural killer cells from bone marrow precursors in vitro by KALLAND, T

“…A simple and highly reproducible bone marrow culture system for the generation of cytolytically active NK cells from immature precursors in the bone marrow is…”
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Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding by Parra, Eduardo, Varga, Mikael, Hedlund, Gunnar, Kalland, Terje, Dohlsten, Mikael

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Physiology of natural killer cells. In vivo regulation of progenitors by interleukin 3 by Kalland, T

“…Adoptive transfer of bone marrow cells to syngeneic lethally irradiated C57BL/6 mice was used to study the maturation of natural killer (NK) cells from their…”
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Superantigen-based tumor therapy : in vivo activation of cytotoxic T cells by HEDLUND, G, DOHLSTEN, M, PETERSSON, C, KALLAND, T

“…We have recently demonstrated that the superantigen staphylococcal enterotoxin A (SEA) targets in vitro activated cytotoxic T lymphocytes against tumor cells…”
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Tumor‐growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: The role of targeted T‐cell co‐stimulation via CD28 by Grosse‐Hovest, Ludger, Brandl, Martina, Dohlsten, Mikael, Kalland, Terje, Wilmanns, Wolfgang, Jung, Gundram

“…The ability of bispecific antibodies with anti‐tumor × anti‐CD3 specificity to mediate the killing of tumor cells by activated T cells has been demonstrated in…”
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Tumor therapy with an antibody-targeted superantigen generates a dichotomy between local and systemic immune responses by Litton, MJ, Dohlsten, M, Hansson, J, Rosendahl, A, Ohlsson, L, Kalland, T, Andersson, J, Andersson, U

“…Repeated injections of a fusion protein containing the superantigen staphylococcal enterotoxin A (SEA) combined with a Fab fragment of a tumor-specific…”
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Prevention of superantigen‐induced down‐regulation of T‐cell mediated cytotoxic activity by IL‐2 in vivo by BELFRAGE, H., DOHLSTEN, M., HEDLUND, G., KALLAND, T.

“…Administration of staphylococcal enterotoxin A (SEA) to mice induces profound activation, cytokine production and cytotoxic activity of both CD4+ and CD8+ T…”
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Monoclonal Antibody-Targeted Superantigens: A Different Class of Anti-Tumor Agents by Dohlsten, Mikael, Hedlund, Gunnar, Akerblom, Eva, Lando, Peter A., Kalland, Terje

“…The bacterial superantigen staphylococcal enterotoxin (SE) A (SEA) directs cytotoxic T lymphocytes (CTLs) expressing particular sequences of the T-cell…”
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Treatment with tumor-reactive Fab-IL-2 and Fab-staphylococcal enterotoxin A fusion proteins leads to sustained T cell activation, and long-term survival of mice with established tumors by Søgaard, M, Ohlsson, L, Kristensson, K, Rosendahl, A, Sjoberg, A, Forsberg, G, Kalland, T, Dohlsten, M

“…C215Fab-IL-2 fusion protein, with full IL-2 and antigen binding activity, was produced in E. coli at high level (>50 mg/l). When co-administered with…”
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Reduced natural killer activity in female mice after neonatal exposure to diethylstilbestrol by Kalland, T

“…Treatment of neonatal female mice with DES markedly reduced the activity of NK cells in adult mice. This finding was most evident in C57BL/6 and BALB/c…”
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