Search Results - "Kalkote, Uttam R."

A highly diastereoselective total synthesis of (±)-heritonin and (±)-heritol by Chavan, Subhash P., Garai, Sumanta, Kalkote, Uttam R.

“…A highly diastereoselective synthesis of heritol and heritonin by intramolecular cyclization on a preformed sensitive butenolide functionality is described…”
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First Enantiospecific Synthesis of (−)-Parvifoline and (−)-Curcuquinone by Chavan, Subhash P, Thakkar, Mahesh, Jogdand, Ganesh F, Kalkote, Uttam R

“…The first enantiospecific synthesis of (−)-parvifoline, employing ring-closing metathesis as the key step, and (−)-curcuquinone from naturally occurring…”
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Total synthesis of (R)-lipoic acid and (S)-lipoic acid via an Mn (III)-salen-catalyzed oxidative kinetic resolution by Purude, Abhijeet N., Pawar, Kailash P., Patil, Niteen B., Kalkote, Uttam R., Chavan, Subhash P.

“…[Display omitted] The asymmetric synthesis of both the antipodes of α-lipoic acid is described. The total synthesis of racemic and asymmetric lipoic acid is…”
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Exploration of L-Proline-Catalyzed [alpha]-Aminoxylation of Aldehyde to (S)-Guaifenesin-Related Drug Molecules by Panchgalle, Sharad P, Kunte, Sunita S, Chavan, Subhash P, Kalkote, Uttam R

“…An efficient enantioselective synthesis of (S)-guaifenesin with >99% ee using L-proline-catalyzed α-aminoxylation of aldehyde as key step is described and…”
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Lipases catalyzed enantioselective hydrolysis of (R,S)-methyl 1,4-benzodioxan-2-carboxylate intermediate for (S)-doxazosin mesylate by Varma, Rita, Kasture, Sangita M, Nene, Sanjay, Kalkote, Uttam R

“…(S)-1,4-benzodioxan-2-carboxylic acid-1 is used as starting compound for the production of the more effective (S) enantiomer of the drug doxazosin mesylate…”
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Diastereoselective Amidoalkylation of (3S,7aR)-6-Benzyl-7-hydroxy-3-phenyltetra- hydro-5H-imidazo[1,5-c][1,3]thiazol-5-one :  A Short and Highly Efficient Synthesis of (+)-Biotin by Chavan, Subhash P, Chittiboyina, Amar G, Ravindranathan, T, Kamat, Subhash K, Kalkote, Uttam R

“…A short and highly efficient synthesis of (+)-biotin in 10 steps with 20% overall yield has been achieved from l-cysteine involving amidoalkylation of hydroxy…”
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Studies toward the Total Synthesis of Carba Analogue of Motif C of M. TB Cell Wall AG Complex by K. Gurjar, Mukund, S. Chorghade, Mukund, Nageswar Reddy, Challa, R. Kalkote, Uttam

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Novel enzymatic route for kinetic resolution of (±)1,4-benzodioxan-2-carboxylic acid by Kasture, Sangita M., Varma, Rita, Kalkote, Uttam R., Nene, Sanjay, Kulkarni, Bhaskar D.

“…Ethyl 1,4-benzodioxan-2-carboxylate is used as an intermediate compound for the production of drug doxazosin mesylate. The title compound was kinetically…”
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Simple, Efficient Chemoenzymatic Synthesis of (S)-5-(tert-Butyldimethylsilyloxy)-2-cyclohexenone and Enantiomeric Ketone Intermediates of 19-Nor-1α,25-dihydroxyvitamin D3 by Kalkote, Uttam R, Ghorpade, Sandeep R, Chavan, Subhash P, Ravindranathan, T

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A convenient chemoenzymatic synthesis of (1 S,7a S)-1-hydroxy-5-oxo-4-(2′-carboxyethyl)-7a-methyltetrahydro-indane—a key intermediate of steroids by Kalkote, Uttam R., Purude, Abhijeet N., Puranik, Vedavati G., Gurjar, Mukund K.

“…A porcine pancreatic lipase mediated enzymatic hydrolysis of (±)-1-acetoxy-5-oxo-4-(2′-carbomethoxyethyl)-7a-methyltetrahydro-indane ( 5b) furnished (1 S,7a…”
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Enantioselective Synthesis of l-CCG-I by Chavan, Subhash P, Sharma, Pallavi, Sivappa, Rasapalli, Bhadbhade, Mohan M, Gonnade, Rajesh G, Kalkote, Uttam R

“…Introduction of natural menthol as the chiral auxiliary in a γ-Br-α,β-unsaturated ester leads to enantioselective generation of three chiral centers in a…”
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Enzymatic kinetic resolution studies of racemic 4-hydroxycyclopent-2-en-1-one using Lipozyme IM by Ghorpade, Sandeep R, Bastawade, Kulbhushan B, Gokhale, Digambar V, Shinde, Popat D, Mahajan, Vishal A, Kalkote, Uttam R, Ravindranathan, T

“…Enzymatic kinetic resolution studies of (±)-4-hydroxycyclopent-2-en-1-one 2 were taken up in organic solvents by transesterification with vinyl acetate and…”
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Efficient Synthesis of Optically Pure (4R,6S)-4-(tert-Butyldimethylsilyloxy)- 6-(hydroxymethyl)tetrahydropyran-2-one and Its Enantiomer by Ghorpade, Sandeep R, Kalkote, Uttam R, Chavan, Subhash P, Bhide, Sunil R, Ravindranathan, T, Puranik, Veda G

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Desymmetrization of meso-cyclopenten- cis-1,4-diol to 4-( R)-hydroxycyclopent-2-en-1-( S)-acetate by irreversible transesterification using Chirazyme by Ghorpade, Sandeep R, Kharul, Rajendra K, Joshi, Rohini R, Kalkote, Uttam R, Ravindranathan, T

“…The parameter optimization study for the desymmetrization of meso-cyclopenten-1,4-diol 1 through irreversible transesterification using an immobilized lipase…”
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A practical and scalable process for 4-( R)-hydroxycyclopent-2-en-1-( S)-acetate by desymmetrization of meso-cyclopent-2-en-1,4-diacetate catalyzed by Trichosporon beigelii (NCIM 3326), a cheap biocatalyst by Kalkote, Uttam R, Ghorpade, Sandeep R, Joshi, Rohini R, Ravindranathan, T, Bastawade, Kulbhushan B, Gokhale, Digambar V

“…Various yeast and fungal cultures from NCIM, NCL, Pune, India were screened for the hydrolysis of meso-cyclopent-2-en-1,4-diacetate 2 to 4-(…”
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Organocatalytic enantioselective synthesis of β-blockers: ( S)-propranolol and ( S)-naftopidil by Panchgalle, Sharad P., Gore, Rohitkumar G., Chavan, Subhash P., Kalkote, Uttam R.

“…An efficient enantioselective synthesis of β-adrenergic blockers ( S)-propranolol and ( S)-naftopidil with >98% ee using an l-proline-catalyzed α-aminoxylation…”
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Asymmetric total synthesis of (2S,3S)-3-hydroxypipecolic acid by Chavan, Subhash P., Dumare, Nilesh B., Harale, Kishor R., Kalkote, Uttam R.

“…A synthetic route to (2S,3S)-3-hydroxypipecolic acid was achieved from readily available nonchiral pool starting material cis-2-butene-1,4-diol and involved…”
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Formal synthesis of (±)-camptothecin via tricyclic lactone as key synthon by Chavan, Subhash P., Dhawane, Abasaheb N., Kalkote, Uttam R.

“…Formal synthesis of (±)-camptothecin via CDE tricyclic lactone employing tandem Michael addition, Dieckmann condensation and addition–elimination reaction as…”
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Enantioselective synthesis of ( R)-(+)-α-lipoic acid via proline-catalyzed sequential α-aminoxylation and HWE olefination of aldehyde by Panchgalle, Sharad P., Jogdand, Ganesh F., Chavan, Subhash P., Kalkote, Uttam R.

“…An efficient enantioselective synthesis of ( R)-(+)-α-lipoic acid is described, in high optical purity (>97% ee), using l-proline-catalyzed sequential…”
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A convenient formal synthesis of (2 S,3 S)-3-hydroxy pipecolic acid by Chavan, Subhash P., Harale, Kishor R., Dumare, Nilesh B., Kalkote, Uttam R.

“…A convenient synthesis of (2 S,3 S)-3-hydroxy pipecolic acid starting from inexpensive and easily available l-(+)-tartaric acid has been described…”
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