Search Results - "Kalinski, Ashley L."

A new neutrophil subset promotes CNS neuron survival and axon regeneration by Sas, Andrew R., Carbajal, Kevin S., Jerome, Andrew D., Menon, Rajasree, Yoon, Choya, Kalinski, Ashley L., Giger, Roman J., Segal, Benjamin M.

“…Transected axons typically fail to regenerate in the central nervous system (CNS), resulting in chronic neurological disability in individuals with traumatic…”
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Locally translated mTOR controls axonal local translation in nerve injury by Terenzio, Marco, Koley, Sandip, Samra, Nitzan, Rishal, Ida, Zhao, Qian, Sahoo, Pabitra K, Urisman, Anatoly, Marvaldi, Letizia, Oses-Prieto, Juan A, Forester, Craig, Gomes, Cynthia, Kalinski, Ashley L, Di Pizio, Agostina, Doron-Mandel, Ella, Perry, Rotem Ben-Tov, Koppel, Indrek, Twiss, Jeffery L, Burlingame, Alma L, Fainzilber, Mike

“…How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic target of rapamycin) was activated and then up-regulated in injured…”
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Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement by Kalinski, Ashley L, Yoon, Choya, Huffman, Lucas D, Duncker, Patrick C, Kohen, Rafi, Passino, Ryan, Hafner, Hannah, Johnson, Craig, Kawaguchi, Riki, Carbajal, Kevin S, Jara, Juan Sebastian, Hollis, Edmund, Geschwind, Daniel H, Segal, Benjamin M, Giger, Roman J

“…Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory…”
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Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition by Kalinski, Ashley L, Kar, Amar N, Craver, John, Tosolini, Andrew P, Sleigh, James N, Lee, Seung Joon, Hawthorne, Alicia, Brito-Vargas, Paul, Miller-Randolph, Sharmina, Passino, Ryan, Shi, Liang, Wong, Victor S C, Picci, Cristina, Smith, Deanna S, Willis, Dianna E, Havton, Leif A, Schiavo, Giampietro, Giger, Roman J, Langley, Brett, Twiss, Jeffery L

“…Inhibition of histone deacetylase 6 (HDAC6) was shown to support axon growth on the nonpermissive substrates myelin-associated glycoprotein (MAG) and…”
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Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size by Perry, Rotem Ben-Tov, Rishal, Ida, Doron-Mandel, Ella, Kalinski, Ashley L., Medzihradszky, Katalin F., Terenzio, Marco, Alber, Stefanie, Koley, Sandip, Lin, Albina, Rozenbaum, Meir, Yudin, Dmitry, Sahoo, Pabitra K., Gomes, Cynthia, Shinder, Vera, Geraisy, Wasim, Huebner, Eric A., Woolf, Clifford J., Yaron, Avraham, Burlingame, Alma L., Twiss, Jeffery L., Fainzilber, Mike

“…How can cells sense their own size to coordinate biosynthesis and metabolism with their growth needs? We recently proposed a motor-dependent bidirectional…”
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The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration by Zhao, Xiao-Feng, Huffman, Lucas D, Hafner, Hannah, Athaiya, Mitre, Finneran, Matthew C, Kalinski, Ashley L, Kohen, Rafi, Flynn, Corey, Passino, Ryan, Johnson, Craig N, Kohrman, David, Kawaguchi, Riki, Yang, Lynda J S, Twiss, Jeffery L, Geschwind, Daniel H, Corfas, Gabriel, Giger, Roman J

“…Upon trauma, the adult murine peripheral nervous system (PNS) displays a remarkable degree of spontaneous anatomical and functional regeneration. To explore…”
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Intra-axonal protein synthesis - a new target for neural repair by Twiss, Jeffery, Kalinski, Ashley, Sachdeva, Rahul, Houle, John

“…Although initially argued to be a feature of immature neurons with incomplete polarization, there is clear evidence that neurons in the peripheral nervous…”
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Neuroinflammation: Breaking barriers and bridging gaps by Estera, Lora A, Walsh, Sam P, Headen, Jordan A, Williamson, Rachel E, Kalinski, Ashley L

“…Neurons are the cells of the nervous system and are responsible for every thought, movement and perception. Immune cells are the cells of the immune system,…”
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Neurobiology: Resetting the axon’s batteries by Twiss, Jeffery L., Kalinski, Ashley L., Sahoo, Pabitra K., Costa, Irene Dalla, Giger, Roman J.

“…Neuronal injury can cause mitochondrial damage, leading to reduced energy production, decreased Ca2+ storage capacity, and increased reactive oxygen species. A…”
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mRNAs and Protein Synthetic Machinery Localize into Regenerating Spinal Cord Axons When They Are Provided a Substrate That Supports Growth by Kalinski, Ashley L, Sachdeva, Rahul, Gomes, Cynthia, Lee, Seung Joon, Shah, Zalak, Houle, John D, Twiss, Jeffery L

“…Although intra-axonal protein synthesis is well recognized in cultured neurons and during development in vivo, there have been few reports of mRNA localization…”
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A HuD‐ZBP1 ribonucleoprotein complex localizes GAP‐43 mRNA into axons through its 3′ untranslated region AU‐rich regulatory element by Yoo, Soonmoon, Kim, Hak H., Kim, Paul, Donnelly, Christopher J., Kalinski, Ashley L., Vuppalanchi, Deepika, Park, Michael, Lee, Seung J., Merianda, Tanuja T., Perrone‐Bizzozero, Nora I., Twiss, Jeffery L.

“…Localized translation of axonal mRNAs contributes to developmental and regenerative axon growth. Although untranslated regions (UTRs) of many different axonal…”
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Protective role of the lipid phosphatase Fig4 in the adult nervous system by Mironova, Yevgeniya A, Lin, Jing-Ping, Kalinski, Ashley L, Huffman, Lucas D, Lenk, Guy M, Havton, Leif A, Meisler, Miriam H, Giger, Roman J

“…Abstract The signaling lipid phosphatidylinositol 3,5-bisphosphate, PI(3,5)P2, functions in vesicular trafficking through the endo-lysosomal compartment…”
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Awakening the stalled axon — Surprises in CSPG gradients by Lee, Seung Joon, Kalinski, Ashley L., Twiss, Jeffery L.

“…The remarkably poor regeneration of axons seen after injury of the brain and spinal cord can result in permanent loss of neural function. This failure of…”
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APC/C Cdh1p and Slx5p/Slx8p ubiquitin ligases confer resistance to aminoglycoside hygromycin B in Saccharomyces cerevisiae by Doss, Ellen M, Tragesser-Tiña, Mary E, Huang, Yanru, Smaldino, Philip J, True, Jason D, Kalinski, Ashley L, Rubenstein, Eric M

“…Multiple ubiquitin ligases with nuclear substrates promote regulated protein degradation and turnover of protein quality control (PQC) substrates. We…”
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Macro-ER-phagy receptors Atg39p and Atg40p confer resistance to aminoglycoside hygromycin B in S. cerevisiae by Daraghmi, Mahmoud M, Miller, Jacob M, Bailey, Connor G, Doss, Ellen M, Kalinski, Ashley L, Smaldino, Philip J, Rubenstein, Eric M

“…Receptor-mediated autophagic turnover of portions of the endoplasmic reticulum (ER) is mediated by macro-ER-phagy. We hypothesized macro-ER-phagy promotes…”
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Neural Progenitor Cells Promote Axonal Growth and Alter Axonal mRNA Localization in Adult Neurons by Merianda, Tanuja T, Jin, Ying, Kalinski, Ashley L, Sahoo, Pabitra K, Fischer, Itzhak, Twiss, Jeffery L

“…The inhibitory environment of the spinal cord and the intrinsic properties of neurons prevent regeneration of axons following CNS injury. However, both…”
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A novel neutrophil subset promotes CNS neuron survival and axon regeneration by Sas, Andrew R., Carbajal, Kevin S., Jerome, Andrew D., Menon, Rajasree, Yoon, Choya, Kalinski, Ashley L., Giger, Roman J., Segal, Benjamin M.

“…Transected axons typically fail to regenerate in the central nervous system (CNS), resulting in chronic neurological disability in individuals with traumatic…”
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Endoplasmic reticulum and inner nuclear membrane ubiquitin-conjugating enzymes Ubc6 and Ubc7 confer resistance to hygromycin B in Saccharomyces cerevisiae by Owutey, Sophia L, Procuniar, Katrina A, Akoto, Emmanuel, Davis, Jacob C, Vachon, Rachel M, O'Malley, LiLi F, Schneider, Hayden O, Smaldino, Philip J, True, Jason D, Kalinski, Ashley L, Rubenstein, Eric M

“…Aberrant endoplasmic reticulum (ER) and inner nuclear membrane (INM) proteins are destroyed through ER-associated degradation (ERAD) and INM-associated…”
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