Search Results - "Kalimuthu, Sangeetha"

Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome by N Kalimuthu, Sangeetha, Wilson, Gavin W, Grant, Robert C, Seto, Matthew, O'Kane, Grainne, Vajpeyi, Rajkumar, Notta, Faiyaz, Gallinger, Steven, Chetty, Runjan

“…Transcriptional analyses have identified several distinct molecular subtypes in pancreatic ductal adenocarcinoma (PDAC) that have prognostic and potential…”
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Gene of the month: SMARCB1 by Kalimuthu, Sangeetha N, Chetty, Runjan

“…SMARCB1 is the core subunit of the SWI/sucrose non-fermenting ATP-dependent chromatin remodelling complex located on the long arm of chromosome 22 (22q11.2)…”
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Towards personalized induction therapy for esophageal adenocarcinoma: organoids derived from endoscopic biopsy recapitulate the pre-treatment tumor by Derouet, Mathieu F., Allen, Jonathan, Wilson, Gavin W., Ng, Christine, Radulovich, Nikolina, Kalimuthu, Sangeetha, Tsao, Ming-Sound, Darling, Gail E., Yeung, Jonathan C.

“…Esophageal adenocarcinoma has few known recurrent mutations and therefore robust, reliable and reproducible patient-specific models are needed for personalized…”
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Co‐existence of multiple myeloma and perivascular endothelial cell tumor by O'Brien, Odharnaith, Kalimuthu, Sangeetha N., Chang, Hong

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Regression grading in neoadjuvant treated pancreatic cancer: an interobserver study by N Kalimuthu, Sangeetha, Serra, Stefano, Dhani, Neesha, Hafezi-Bakhtiari, Sara, Szentgyorgyi, Eva, Vajpeyi, Rajkumar, Chetty, Runjan

“…Several regression grading systems have been proposed for neoadjuvant chemoradiation-treated pancreatic ductal adenocarcinoma (PDAC). This study aimed to…”
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The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes by Kalimuthu, Sangeetha N, Serra, Stefano, Dhani, Neesha, Chetty, Runjan

“…Preoperative (neoadjuvant) chemoradiation therapy/treatment (NCRT) is emerging as an important treatment modality in borderline resectable pancreatic ductal…”
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Normothermic ex situ pancreas perfusion for the preservation of porcine pancreas grafts by Mazilescu, Laura I., Parmentier, Catherine, Kalimuthu, Sangeetha N., Ganesh, Sujani, Kawamura, Masataka, Goto, Toru, Noguchi, Yuki, Selzner, Markus, Reichman, Trevor W.

“…Pancreas transplantation improves and extends the life of patients with insulin‐dependent diabetes. Pancreata from extended criteria donors have been…”
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Barrett’s Esophagus and Esophageal Adenocarcinoma: A Histopathological Perspective by Zyla, Roman E., Kalimuthu, Sangeetha N.

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Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma by Connor, Ashton A, Denroche, Robert E, Jang, Gun Ho, Timms, Lee, Kalimuthu, Sangeetha N, Selander, Iris, McPherson, Treasa, Wilson, Gavin W, Chan-Seng-Yue, Michelle A, Borozan, Ivan, Ferretti, Vincent, Grant, Robert C, Lungu, Ilinca M, Costello, Eithne, Greenhalf, William, Palmer, Daniel, Ghaneh, Paula, Neoptolemos, John P, Buchler, Markus, Petersen, Gloria, Thayer, Sarah, Hollingsworth, Michael A, Sherker, Alana, Durocher, Daniel, Dhani, Neesha, Hedley, David, Serra, Stefano, Pollett, Aaron, Roehrl, Michael H A, Bavi, Prashant, Bartlett, John M S, Cleary, Sean, Wilson, Julie M, Alexandrov, Ludmil B, Moore, Malcolm, Wouters, Bradly G, McPherson, John D, Notta, Faiyaz, Stein, Lincoln D, Gallinger, Steven

“…Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain poor. Advances in next-generation sequencing provide a route to therapeutic…”
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Normothermic Ex Vivo Machine Perfusion of Discarded Human Pancreas Allografts: A Feasibility Study by Parmentier, Catherine, Ray, Samrat, Mazilescu, Laura I, Kawamura, Masataka, Noguchi, Yuki, Nogueira, Emmanuel, Ganesh, Sujani, Arulratnam, Bhranavi, Kalimuthu, Sangeetha N, Selzner, Markus, Reichman, Trevor W

“…Pancreas transplantation is the only curative treatment for patients with complicated diabetes, and organ shortage is a common and increasing problem…”
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An unusual primary malignant tumor of the stomach: fetal gutlike gastric adenocarcinoma with “blastoma”-like component by Taher, Altaf, Denic, Nebojsa, Kalimuthu, Sangeetha N., Chetty, Runjan

“…An unusual case of a polypoid, malignant gastric tumor in a 62-year-old man is presented. Endoscopy and subsequent polypectomy revealed an 8.5 × 6.5 × 4.5–cm…”
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Mucin‐rich variant of traditional serrated adenoma: a distinct morphological variant by N Kalimuthu, Sangeetha, Serra, Stefano, Hafezi‐Bakhtiari, Sara, Colling, Richard, Wang, Lai Mun, Chetty, Runjan

“…Aims Traditional serrated adenomas (TSAs) account for 5% of serrated polyps, and have a villiform architecture, eosinophilic cells with a brush border, and…”
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Mutations in the RAS/MAPK Pathway Drive Replication Repair-Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition by Campbell, Brittany B, Galati, Melissa A, Stone, Simone C, Riemenschneider, Alexandra N, Edwards, Melissa, Sudhaman, Sumedha, Siddaway, Robert, Komosa, Martin, Nunes, Nuno M, Nobre, Liana, Morrissy, A Sorana, Zatzman, Matthew, Zapotocky, Michal, Joksimovic, Lazar, Kalimuthu, Sangeetha N, Samuel, David, Mason, Gary, Bouffet, Eric, Morgenstern, Daniel A, Aronson, Melyssa, Durno, Carol, Malkin, David, Maris, John M, Taylor, Michael D, Shlien, Adam, Pugh, Trevor J, Ohashi, Pamela S, Hawkins, Cynthia E, Tabori, Uri

“…The RAS/MAPK pathway is an emerging targeted pathway across a spectrum of both adult and pediatric cancers. Typically, this is associated with a single,…”
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Sclerosing Tumors of the Gastrointestinal Tract: A Systematic Approach by Chelliah, Adeline, Kalimuthu, Sangeetha N., Chetty, Runjan

“…Some lesions in the gastrointestinal tract have a propensity for sclerosis such that it may mask the actual true nature of the lesion. The purpose of this…”
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Primary Inferior Vena Cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum by Chetty, Runjan, Kalimuthu, Sangeetha N, Heinonen, Hanna-Riikka

“…Abstract A male patient with obstructive jaundice was found to have an incidental nodule within the inferior vena cava (IVC), below the level of the renal…”
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Reanimating Pancreatic Grafts Subjected to Prolonged Cold Ischemic Injury Using Normothermic Ex Vivo Perfusion by Ray, Samrat, Parmentier, Catherine, Kawamura, Masataka, Ganesh, Sujani, Nogueira, Emmanuel, Novoa, Francisco Calderon, Hobeika, Christian, Chu, Tunpang, Kalimuthu, Sangeetha N, Selzner, Markus, Reichman, Trevor W

“…Pancreas transplant volumes are limited because of poor utilization of "extended criteria grafts." Prolonged cold ischemia is a risk factor associated with…”
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Combination of clinical, radiomic, and “delta” radiomic features in survival prediction of metastatic gastroesophageal adenocarcinoma by Krishna, Satheesh, Sertic, Andrew, Liu, Zhihui (Amy), Liu, Zijin, Darling, Gail E., Yeung, Jonathon, Wong, Rebecca, Chen, Eric X., Kalimuthu, Sangeetha, Allen, Michael J., Suzuki, Chihiro, Panov, Elan, Ma, Lucy X., Bach, Yvonne, Jang, Raymond W., Swallow, Carol J., Brar, Savtaj, Elimova, Elena, Veit-Haibach, Patrick

“…Objectives To identify combined clinical, radiomic, and delta-radiomic features in metastatic gastroesophageal adenocarcinomas (GEAs) that may predict survival…”
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Next-generation sequencing is highly sensitive for the detection of beta-catenin mutations in desmoid-type fibromatoses by Aitken, Sarah J., Presneau, Nadège, Kalimuthu, Sangeetha, Dileo, Palma, Berisha, Fitim, Tirabosco, Roberto, Amary, M. Fernanda, Flanagan, Adrienne M.

“…Desmoid-type fibromatoses are locally aggressive and frequently recurrent tumours, and an accurate diagnosis is essential for patient management. The majority…”
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Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett’s Esophagus by Gotovac, Jovana R., Kader, Tanjina, Milne, Julia V., Fujihara, Kenji M., Lara-Gonzalez, Luis E., Gorringe, Kylie L., Kalimuthu, Sangeetha N., Jayawardana, Madawa W., Duong, Cuong P., Phillips, Wayne A., Clemons, Nicholas J.

“…Esophageal adenocarcinoma (EAC) develops from its precursor Barrett’s esophagus through intermediate stages of low- and high-grade dysplasia. However,…”
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From traditional serrated adenoma to tubulovillous adenoma and beyond by Kalimuthu, Sangeetha N, Chelliah, Adeline, Chetty, Runjan

“…It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous…”
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