Trends in Asymmetric Michael Reactions Catalysed by Tripeptides in Combination with an Achiral Additive in Different Solvents

The potential of tripeptides 3, 6 and 12 as chiral catalysts for asymmetric Michael addition reactions in the presence of an achiral additive has been tested in different solvents (CHCl3, acetone, DMF, DMSO and the room‐temperature ionic liquid [bmim]PF6). The dependence of yields and enantiomeric e...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of organic chemistry Vol. 2004; no. 19; pp. 4014 - 4019
Main Authors:	Tsogoeva, Svetlana B., Jagtap, Sunil B., Ardemasova, Zoya A., Kalikhevich, Victor N.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01-10-2004 WILEY‐VCH Verlag
Subjects:	Asymmetric catalysis Michael addition Organocatalyst Peptides
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The potential of tripeptides 3, 6 and 12 as chiral catalysts for asymmetric Michael addition reactions in the presence of an achiral additive has been tested in different solvents (CHCl3, acetone, DMF, DMSO and the room‐temperature ionic liquid [bmim]PF6). The dependence of yields and enantiomeric excesses on the solvent used has been demonstrated. The experiments show that the combination of additive and peptides provides a catalytic system that appears to be better than the sum of its parts. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Bibliography:	ark:/67375/WNG-R75GKWVW-K ArticleID:EJOC200400243 istex:229532D96EC32D0928CF3D28EB7397894BF2D60F
ISSN:	1434-193X 1099-0690
DOI:	10.1002/ejoc.200400243