Search Results - "Kalia, Y. N"

Non-invasive iontophoretic delivery of enzymatically active ribonuclease A (13.6 kDa) across intact porcine and human skins by Dubey, S., Kalia, Y.N.

“…The purpose of the study was to demonstrate the feasibility of using transdermal iontophoresis to deliver a functional protein, ribonuclease A (RNAse; 13.6…”
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Skin penetration and distribution of polymeric nanoparticles by Alvarez-Román, R., Naik, A., Kalia, Y.N., Guy, R.H., Fessi, H.

“…Encapsulation using nanoparticulate systems is an increasingly implemented strategy in drug targeting and delivery. Such systems have also been proposed for…”
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Novel micelle formulations to increase cutaneous bioavailability of azole antifungals by Bachhav, Y.G., Mondon, K., Kalia, Y.N., Gurny, R., Möller, M.

“…Efficient topical drug administration for the treatment of superficial fungal infections would deliver the therapeutic agent to the target compartment and…”
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Effect of controlled laser microporation on drug transport kinetics into and across the skin by Bachhav, Y.G., Summer, S., Heinrich, A., Bragagna, T., Böhler, C., Kalia, Y.N.

“…The objectives of this study were to investigate a novel laser microporation technology ( P.L.E.A.S.E. Painless Laser Epidermal System) and to determine the…”
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Understanding the poor iontophoretic transport of lysozyme across the skin: When high charge and high electrophoretic mobility are not enough by Dubey, S., Kalia, Y.N.

“…The original aim of the study was to investigate the transdermal iontophoretic delivery of lysozyme and to gain further insight into the factors controlling…”
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Electrically-assisted delivery of an anionic protein across intact skin: Cathodal iontophoresis of biologically active ribonuclease T1 by Dubey, S., Kalia, Y.N.

“…Cathodal iontophoresis of anionic macromolecules has been considered a major challenge owing to (i) the presence of a negative charge on the skin under…”
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Visualization of skin penetration using confocal laser scanning microscopy by Alvarez-Román, R, Naik, A, Kalia, Y.N, Fessi, H, Guy, R.H

“…The use of skin as an alternative route for administering systemically active drugs has attracted considerable interest in recent years. However, the skin…”
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Noninvasive Transdermal Iontophoretic Delivery of Biologically Active Human Basic Fibroblast Growth Factor by Dubey, S, Perozzo, R, Scapozza, L, Kalia, Y. N

“…Human basic fibroblast growth factor (hbFGF; 17.4 kDa) has shown promise in the treatment of several dermatological conditions; symptomatic improvement was…”
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Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo by Sekkat, N, Kalia, Y N, Guy, R H

“…The goal of this work was to establish, using biophysical characterization, that porcine ear skin in vitro is a valid model for its human counterpart…”
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Factors and strategies for improving buccal absorption of peptides by Veuillez, F, Kalia, Y.N, Jacques, Y, Deshusses, J, Buri, P

“…Peptides and polypeptides have important pharmacological properties but only a limited number (e.g. insulin, oxytocin, vasopressin) have been exploited as…”
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Skin permeation enhancement by sucrose esters: A pH-dependent phenomenon by Cázares-Delgadillo, J., Naik, A., Kalia, Y.N., Quintanar-Guerrero, D., Ganem-Quintanar, A.

“…The purpose of the present study was to evaluate the effect of sucrose esters (particularly, sucrose laureate and sucrose oleate in Transcutol ®) on the…”
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Transdermal iontophoresis of dexamethasone sodium phosphate in vitro and in vivo: Effect of experimental parameters and skin type on drug stability and transport kinetics by Cázares-Delgadillo, J., Balaguer-Fernández, C., Calatayud-Pascual, A., Ganem-Rondero, A., Quintanar-Guerrero, D., López-Castellano, A.C., Merino, V., Kalia, Y.N.

“…The aim of this study was to investigate the cathodal iontophoresis of dexamethasone sodium phosphate (DEX-P) in vitro and in vivo and to determine the…”
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Skin permeability enhancement by low frequency sonophoresis: lipid extraction and transport pathways by Alvarez-Román, R, Merino, G, Kalia, Y N, Naik, A, Guy, R H

“…The objective of this study was to shed light on the mechanism(s) by which low-frequency ultrasound (20 KHz) enhances the permeability of the skin. The…”
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Iontophoresis: electrorepulsion and electroosmosis by Guy, Richard H., Kalia, Yogeshvar N., Delgado-Charro, M.Begoña, Merino, Virginia, López, Alicia, Marro, Diego

“…Over the last 10–15 years, the electrical enhancement of drug delivery across the skin has undergone intense investigation. During this period, considerable…”
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Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1B and a poly-ARG interferon beta-1B analogue by Dubey, S, Perozzo, R, Scapozza, L, Kalia, Y N

“…The first objective was to investigate the transdermal iontophoresis of interferon beta 1b (IFN); the second was to determine whether the addition of 10 Arg…”
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Using protease inhibitors to improve protein stability in the presence of skin: A case study on the stability of insulin like growth factor 1 by Dubey, S., Perozzo, R., Scapozza, L., Kalia, Y.N.

“…Insulin-like growth factor 1 (IGF-1) is indicated for growth failure in pediatric patients with primary IGF-1 deficiency and for patients with neutralizing…”
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Specific protein-protein interactions limit the cutaneous iontophoretic transport of interferon beta-1b and a poly-Arg interferon beta-1b analogue by Dubey, S., Perozzo, R., Scapozza, L., Kalia, Y.N.

“…[Display omitted] The first objective was to investigate the transdermal iontophoresis of interferon beta 1b (IFN); the second was to determine whether the…”
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Development of an in vitro model for premature neonatal skin: biophysical characterization using transepidermal water loss by Sekkat, N, Kalia, Y N, Guy, R H

“…The objective was to develop an in vitro model for the developing skin of the premature neonate. Barriers of different levels of efficiency were produced by…”
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Modeling transdermal drug release by Kalia, Yogeshvar N., Guy, Richard H.

“…The stratum corneum forms the outermost layer of the skin and is essentially a multilamellar lipid milieu punctuated by protein-filled corneocytes that augment…”
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Contributions of electromigration and electroosmosis to iontophoretic drug delivery by MARRO, Diego, KALIA, Yogeshvar N, BEGONA DELGADO-CHARRO, M, GUY, Richard H

“…To determine the electromigration and electroosmotic contributions to the iontophoretic delivery of lidocaine hydrochloride, in addition to the more-lipophilic…”
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