Search Results - "Kalia, Lorraine V."

Disease-modifying strategies for Parkinson's disease by Kalia, Lorraine V., Kalia, Suneil K., Lang, Anthony E.

“…Parkinson's disease (PD) is an increasingly prevalent and progressively disabling neurodegenerative disease. The impact of PD on patients and their families as…”
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NMDA receptors in clinical neurology: excitatory times ahead by Kalia, Lorraine V, MD, Kalia, Suneil K, MD, Salter, Michael W, PhD

“…Summary Since the N-methyl-D-aspartate receptor (NMDAR) subunits were cloned less than two decades ago, a substantial amount of research has been invested into…”
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LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease? by O’Hara, Darren M., Pawar, Grishma, Kalia, Suneil K., Kalia, Lorraine V.

“…Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, characterized by prominent degeneration of dopaminergic neurons in the…”
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High frequency electrical stimulation reduces α-synuclein levels and α-synuclein-mediated autophagy dysfunction by George, Jimmy, Shafiq, Kashfia, Kapadia, Minesh, Kalia, Lorraine V., Kalia, Suneil K.

“…Accumulation of α-synuclein (α-Syn) has been implicated in proteasome and autophagy dysfunction in Parkinson’s disease (PD). High frequency electrical…”
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Novel nondopaminergic targets for motor features of Parkinson's disease: Review of recent trials by Kalia, Lorraine V., Brotchie, Jonathan M., Fox, Susan H.

“…Neurotransmitters other than dopamine are recognized as having modulatory roles within the basal ganglia and can influence the basal ganglia dopaminergic…”
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Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy by Earnshaw, Rebecca, Zhang, Yu Tong, Heymann, Gregory, Fujisawa, Kazuko, Hui, Sarah, Kapadia, Minesh, Kalia, Lorraine V., Kalia, Suneil K.

“…C-terminus of HSP70 interacting protein (CHIP) is an E3 ubiquitin ligase and HSP70 cochaperone. Mutations in the CHIP encoding gene are the cause of two…”
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Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors by Pitcher, Graham M, Kalia, Lorraine V, Ng, David, Goodfellow, Nathalie M, Yee, Kathleen T, Lambe, Evelyn K, Salter, Michael W

“…Schizophrenia has been associated with overactive neuregulin signaling and with glutamatergic synaptic hypoactivity. Now, in brain slice culture experiments,…”
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Introduction: The Earliest Phase of Parkinson’s Disease: Possibilities for Detection and Intervention by Berg, Daniela, Bloem, Bastiaan R., Kalia, Lorraine V., Postuma, Ron B.

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Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease by Nim, Satra, O’Hara, Darren M., Corbi-Verge, Carles, Perez-Riba, Albert, Fujisawa, Kazuko, Kapadia, Minesh, Chau, Hien, Albanese, Federica, Pawar, Grishma, De Snoo, Mitchell L., Ngana, Sophie G., Kim, Jisun, El-Agnaf, Omar M. A., Rennella, Enrico, Kay, Lewis E., Kalia, Suneil K., Kalia, Lorraine V., Kim, Philip M.

“…Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a…”
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Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein by McKinnon, Chris, De Snoo, Mitchell L, Gondard, Elise, Neudorfer, Clemens, Chau, Hien, Ngana, Sophie G, O'Hara, Darren M, Brotchie, Jonathan M, Koprich, James B, Lozano, Andres M, Kalia, Lorraine V, Kalia, Suneil K

“…Parkinson's disease is a progressive neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein in selected brain regions, including…”
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Genetic Testing in Clinical Movement Disorders: A Case-Based Review by Kalia, Lorraine V, Nimmo, Graeme A M, Mestre, Tiago A

“…Genetics are fundamental to understanding the pathophysiology of neurological disease, including movement disorders. Genetic testing in clinical practice has…”
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Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5) by Kalia, Lorraine V, Kalia, Suneil K, Chau, Hien, Lozano, Andres M, Hyman, Bradley T, McLean, Pamela J

“…Parkinson's disease (PD) is a common neurodegenerative condition in which abnormalities in protein homeostasis, or proteostasis, may lead to accumulation of…”
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C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside by Mylvaganam, Sivakami, Earnshaw, Rebecca, Heymann, Gregory, Kalia, Suneil K, Kalia, Lorraine V

“…Neurodegenerative diseases are characterized by the increasing dysfunction and death of neurons, resulting in progressive impairment of a person’s mobility…”
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Reduction of alpha-synuclein oligomers in preclinical models of Parkinson’s disease by electrical stimulation in vitro and deep brain stimulation in vivo by Lee, Eun Jung, Aguirre-Padilla, David Hernán, Fomenko, Anton, Pawar, Grishma, Kapadia, Minesh, George, Jimmy, Lozano, Andres M., Hamani, Clement, Kalia, Lorraine V., Kalia, Suneil K.

“…Deep brain stimulation (DBS) has been widely used to manage debilitating neurological symptoms in movement disorders such as Parkinson's disease (PD). Despite…”
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If Art Were a Drug: Implications for Parkinson’s Disease by Gros, Priti, Spee, Blanca T.M., Bloem, Bastiaan R., Kalia, Lorraine V.

“…Parkinson’s disease (PD) is a chronic and complex neurodegenerative disorder. Conventional pharmacological or surgical therapies alone are often insufficient…”
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Cavitation Feedback Control of Focused Ultrasound Blood-Brain Barrier Opening for Drug Delivery in Patients with Parkinson's Disease by Huang, Yuexi, Meng, Ying, Pople, Christopher B, Bethune, Allison, Jones, Ryan M, Abrahao, Agessandro, Hamani, Clement, Kalia, Suneil K, Kalia, Lorraine V, Lipsman, Nir, Hynynen, Kullervo

“…Magnetic resonance-guided focused ultrasound (MRgFUS), in conjunction with circulating microbubbles, is an emerging technology that can transiently enhance the…”
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Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis by O'Hara, Darren M, Kapadia, Minesh, Ping, Susan, Kalia, Suneil K, Kalia, Lorraine V

“…Estimation of the number of dopaminergic neurons in the substantia nigra is a key method in pre-clinical Parkinson's disease research. Currently, unbiased…”
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Current Progress in Magnetic Resonance-Guided Focused Ultrasound to Facilitate Drug Delivery across the Blood-Brain Barrier by Meng, Ying, Kalia, Lorraine V, Kalia, Suneil K, Hamani, Clement, Huang, Yuexi, Hynynen, Kullervo, Lipsman, Nir, Davidson, Benjamin

“…This review discusses the current progress in the clinical use of magnetic resonance-guided focused ultrasound (MRgFUS) and other ultrasound platforms to…”
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Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning by Ng, David, Pitcher, Graham M, Szilard, Rachel K, Sertié, Andréa, Kanisek, Marijana, Clapcote, Steven J, Lipina, Tatiana, Kalia, Lorraine V, Joo, Daisy, McKerlie, Colin, Cortez, Miguel, Roder, John C, Salter, Michael W, McInnes, Roderick R

“…The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic…”
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Regulation of Parkin-dependent mitophagy by Bcl-2-associated athanogene (BAG) family members by Kapadia, Minesh, De Snoo, Mitchell, Kalia, Lorraine, Kalia, Suneil

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