Search Results - "Kalhor, Hourieh"

Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors by Poorebrahim, Mansour, Abazari, Mohammad Foad, Moradi, Leila, Shahbazi, Behzad, Mahmoudi, Reza, Kalhor, Hourieh, Askari, Hassan, Teimoori-Toolabi, Ladan

“…K-Ras activating mutations are significantly associated with tumor progression and aggressive metastatic behavior in various human cancers including pancreatic…”
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Identification of candidate genes and miRNAs for sensitizing resistant colorectal cancer cells to oxaliplatin and irinotecan by Poorebrahim, Mansour, Sadeghi, Solmaz, Ghanbarian, Marzieh, Kalhor, Hourieh, Mehrtash, Amirhosein, Teimoori-Toolabi, Ladan

“…Drug resistance to irinotecan and oxaliplatin, two widely used chemotherapeutic, has become a common problem in cancerous patients. Despite numerous valuable…”
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Identification of Putative Drug Targets in Highly Resistant Gram-Negative Bacteria; and Drug Discovery Against Glycyl-tRNA Synthetase as a New Target by Fereshteh, Sepideh, Noori Goodarzi, Narjes, Kalhor, Hourieh, Rahimi, Hamzeh, Barzi, Seyed Mahmoud, Badmasti, Farzad

“…Background: Gram-negative bacterial infections are on the rise due to the high prevalence of multidrug-resistant bacteria, and efforts must be made to identify…”
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Comparison of Agar screen and duplex-PCR methods in determination of methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from nasal carriage by Hourieh Kalhor

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Repurposing of the approved small molecule drugs in order to inhibit SARS-CoV-2 S protein and human ACE2 interaction through virtual screening approaches by Kalhor, Hourieh, Sadeghi, Solmaz, Abolhasani, Hoda, Kalhor, Reyhaneh, Rahimi, Hamzeh

“…Most recently, the new coronavirus (SARS-CoV-2) has been recognized as a pandemic by the World Health Organization (WHO) while this virus shares substantial…”
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Homology modeling and molecular docking studies to decrease glutamine affinity of Yarrowia lipolytica L-asparaginase by Darvishi, Farshad, Beiranvand, Elham, Kalhor, Hourieh, Shahbazi, Behzad, Mafakher, Ladan

“…L-Asparaginase is a key component in the treatment of leukemias and lymphomas. However, the glutamine affinity of this therapeutic enzyme is an off-target…”
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Interactions of heparin derivatives with recombinant human keratinocyte growth factor: Structural stability and bioactivity effect study by Kalhor, Hourieh, Abolhasani, Hoda, Kalhor, Reyhaneh, komeili Movahhed, Tahereh, Rahimi, Hamzeh

“…Heparin and heparan sulfate are important glycosaminoglycans that can regulate the activities of many vital proteins, especially the fibroblast growth factor…”
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Identification of novel drug targets in Porphyromonas gingivalis and proposing inhibitors against acetate kinase using structure-based virtual screening by Kalhor, Hourieh, Noori Goodarzi, Narjes, Rahimi, Hamzeh, Firoozeh, Farzaneh, Badmasti, Farzad

“…Porphyromonas gingivalis is the conductor of the orchestration of periodontium inflammation. Considering that a wide range of antibiotics have lost their…”
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Effects of tosyl-l-arginine methyl ester (TAME) on the APC/c subunits: An in silico investigation for inhibiting cell cycle by Marashiyan, Mahya, Kalhor, Hourieh, Ganji, Maziar, Rahimi, Hamzeh

“…The anaphase-promoting complex/cyclosome (APC/c) is requisite for controlling mitosis, which is activated by Cdh1 and Cdc20 activators. Dysregulation of APC/c…”
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Keratinocyte growth factor in focus: A comprehensive review from structural and functional aspects to therapeutic applications of palifermin by Sadeghi, Solmaz, Kalhor, Hourieh, Panahi, Mohammad, Abolhasani, Hoda, Rahimi, Bahareh, Kalhor, Reyhaneh, Mehrabi, Amirmehdi, Vahdatinia, Mahsa, Rahimi, Hamzeh

“…Palifermin (Kepivance™) is the first therapeutic approved by the Food and Drug Administration for preventing and managing the oral mucositis provoked by…”
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Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors by Mansour Poorebrahim, Mohammad Foad Abazari, Leila Moradi, Behzad Shahbazi, Reza Mahmoudi, Hourieh Kalhor, Hassan Askari, Ladan Teimoori-Toolabi

“…K-Ras activating mutations are significantly associated with tumor progression and aggressive metastatic behavior in various human cancers including pancreatic…”
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In silico enhancement of the stability and activity of keratinocyte growth factor by Poorebrahim, Mansour, Sadeghi, Solmaz, Ghorbani, Raziyeh, Asghari, Matin, Abazari, Mohammad Foad, Kalhor, Hourieh, Rahimi, Hamzeh

“…Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family, has been implicated in some biological processes such as cell…”
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In silico mutagenesis in recombinant human keratinocyte growth factor: Improvement of stability and activity in addition to decrement immunogenicity by Kalhor, Hourieh, Sadeghi, Solmaz, Marashiyan, Mahya, Enssi, Maryam, Kalhor, Reyhaneh, Ganji, Maziar, Rahimi, Hamzeh

“…The recombinant human keratinocyte growth factor (rhKGF) is clinically applied to decrease the incidence and duration of cancer therapeutic agents…”
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Identification of new DNA gyrase inhibitors based on bioactive compounds from streptomyces: structure-based virtual screening and molecular dynamics simulations approaches by Kalhor, Hourieh, Sadeghi, Solmaz, Marashiyan, Mahya, Kalhor, Reyhaneh, Aghaei Gharehbolagh, Sanaz, Akbari Eidgahi, Mohammad Reza, Rahimi, Hamzeh

“…DNA gyrase enzyme has vital role in bacterial survival and can be considered as a potential drug target. Owing to the appearance of resistance to…”
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Rational design of inhibitors against LpxA protein of Acinetobacter baumannii using a virtual screening method by Fereshteh, Sepideh, Kalhor, Hourieh, Sepehr, Amin, Rahimi, Hamzeh, Zafari, Mahdi, Ahangari Cohan, Reza, Badmasti, Farzad

“…Acinetobacter baumannii is a highly antimicrobial resistant nosocomial pathogen. Resistance to currently used antibiotics has limited effective drugs against…”
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Novel Small Molecules against Two Binding Sites of Wnt2 Protein as potential Drug Candidates for Colorectal Cancer: A Structure Based Virtual Screening Approach by Kalhor, Hourieh, Rahimi, Hamzeh, Akbari Eidgahi, Mohammad Reza, Teimoori-Toolabi, Ladan

“…Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands,…”
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Structural and dynamic characterization of human Wnt2-Fzd7 complex using computational approaches by Kalhor, Hourieh, Poorebrahim, Mansour, Rahimi, Hamzeh, Shabani, Ali Akbar, Karimipoor, Morteza, Akbari Eidgahi, Mohammad Reza, Teimoori-Toolabi, Ladan

“…Wnt and Frizzled (Fzd) family members play crucial roles in the self-renewal of tumor-initiating cells. Until now, only a few studies have addressed the…”
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Evaluation of the Frequency of Methicillin-Resistant Staphylococs Isolated from Nose of Nursing Personnel of Hajar Hospital of Shahrekord by Hourieh Kalhor, Majid Validi, Mohammad-Reza Nafisi

“…Background and Objectives: Methicillin-resistant Staphylococcus strains, as one of the most important etiologic agents of nosocomial infections are of…”
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Evaluation of the Frequency of Methicillin-Resistant Staphylococs Isolated from Nose of Nursing Personnel of Hajar Hospital of Shahrekord by Hourieh Kalhor, Majid Validi, Mohammad-Reza Nafisi

“…Background and Objectives: Methicillin-resistant Staphylococcus strains, as one of the most important etiologic agents of nosocomial infections are of…”
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Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome by Reyhaneh Kalhor, naser kalhor, Hourieh Kalhor, Mojtaba Sohrabi

“…Abstract Introduction: Polycystic ovary syndrome (PCOS) is a very complex and heterogeneous disorder that genetic and environmental factors have a significant…”
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