Search Results - "Kalekar, Radha"

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer by Zadra, Giorgia, Ribeiro, Caroline F., Chetta, Paolo, Ho, Yeung, Cacciatore, Stefano, Gao, Xueliang, Syamala, Sudeepa, Bango, Clyde, Photopoulos, Cornelia, Huang, Ying, Tyekucheva, Svitlana, Bastos, Debora C., Tchaicha, Jeremy, Lawney, Brian, Uo, Takuma, D’Anello, Laura, Csibi, Alfredo, Kalekar, Radha, Larimer, Benjamin, Ellis, Leigh, Butler, Lisa M., Morrissey, Colm, McGovern, Karen, Palombella, Vito J., Kutok, Jeffery L., Mahmood, Umar, Bosari, Silvano, Adams, Julian, Peluso, Stephane, Dehm, Scott M., Plymate, Stephen R., Loda, Massimo

“…A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty…”
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Discovery of a selective inhibitor of doublecortin like kinase 1 by Ferguson, Fleur M., Nabet, Behnam, Raghavan, Srivatsan, Liu, Yan, Leggett, Alan L., Kuljanin, Miljan, Kalekar, Radha L., Yang, Annan, He, Shuning, Wang, Jinhua, Ng, Raymond W. S., Sulahian, Rita, Li, Lianbo, Poulin, Emily J., Huang, Ling, Koren, Jost, Dieguez-Martinez, Nora, Espinosa, Sergio, Zeng, Zhiyang, Corona, Cesear R., Vasta, James D., Ohi, Ryoma, Sim, Taebo, Kim, Nam Doo, Harshbarger, Wayne, Lizcano, Jose M., Robers, Matthew B., Muthaswamy, Senthil, Lin, Charles Y., Look, A. Thomas, Haigis, Kevin M., Mancias, Joseph D., Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Westover, Kenneth D., Gray, Nathanael S.

“…Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC)…”
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Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity by Williams, Hannah L, Dias Costa, Andressa, Zhang, Jinming, Raghavan, Srivatsan, Winter, Peter S, Kapner, Kevin S, Ginebaugh, Scott P, Väyrynen, Sara A, Väyrynen, Juha P, Yuan, Chen, Navia, Andrew W, Wang, Junning, Yang, Annan, Bosse, Timothy L, Kalekar, Radha L, Lowder, Kristen E, Lau, Mai Chan, Elganainy, Dalia, Morales-Oyarvide, Vicente, Rubinson, Douglas A, Singh, Harshabad, Perez, Kimberly, Cleary, James M, Clancy, Thomas E, Wang, Jiping, Mancias, Joseph D, Brais, Lauren K, Hill, Emma R, Kozak, Margaret M, Linehan, David C, Dunne, Richard F, Chang, Daniel T, Koong, Albert C, Hezel, Aram F, Hahn, William C, Shalek, Alex K, Aguirre, Andrew J, Nowak, Jonathan A, Wolpin, Brian M

“…Pancreatic ductal adenocarcinoma (PDAC) has been classified into classical and basal-like transcriptional subtypes by bulk RNA measurements. However, recent…”
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

“…Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new…”
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

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Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain by Meinke, Gretchen, Phelan, Paul J, Kalekar, Radha, Shin, Jong, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A

“…JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a…”
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Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer by Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

“…Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and…”
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Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity by Williams, Hannah L., Dias Costa, Andressa, Zhang, Jinming, Raghavan, Srivatsan, Winter, Peter S., Kapner, Kevin S., Ginebaugh, Scott P., Väyrynen, Sara A., Väyrynen, Juha P., Yuan, Chen, Navia, Andrew W., Wang, Junning, Yang, Annan, Bosse, Timothy L., Kalekar, Radha L., Lowder, Kristen E., Lau, Mai Chan, Elganainy, Dalia, Morales-Oyarvide, Vicente, Rubinson, Douglas A., Singh, Harshabad, Perez, Kimberly, Cleary, James M., Clancy, Thomas E., Wang, Jiping, Mancias, Joseph D., Brais, Lauren K., Hill, Emma R., Kozak, Margaret M., Linehan, David C., Dunne, Richard F., Chang, Daniel T., Koong, Albert C., Hezel, Aram F., Hahn, William C., Shalek, Alex K., Aguirre, Andrew J., Nowak, Jonathan A., Wolpin, Brian M.

“…Pancreatic ductal adenocarcinoma (PDAC) has been classified into classical and basal-like transcriptional subtypes by bulk RNA measurements. However, recent…”
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Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q by Neggers, Jasper E., Paolella, Brenton, Asfaw, Adhana, Rothberg, Michael V., Skipper, Tom A., Kalekar, Radha, Burger, Michael, Dharia, Neekesh, Kugener, Guillaume, Kalfon, Jeremie, Dumont, Nancy, Li, Yvonne, Spurr, Liam, Yang, Annan, Wu, Wenbo, Durbin, AndrewAdam, Wolpin, Brian M., Root, David E., Boehm, Jesse, Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd, Vazquez, Francisca, Aguirre, Andrew J.

“…Abstract Background: Discovery of new biomarker-linked cancer therapeutic targets may enable novel drug development and ultimately lead to advances in clinical…”
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Abstract PR15: Assessment of tumor heterogeneity, clonal evolution, and the stromal microenvironment in metastatic pancreatic ductal adenocarcinoma and matched patient-derived organoids by Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew, Kalekar, Radha, Galvez-Reyes, Jennyfer, Prakadan, Sanjay, Wang, Junning, Reilly, Emma, Brais, Lauren, Cleary, James M., Nowak, Jonathan, Wolpin, Brian M., Shalek, Alex K., Aguirre, Andrew J., Hahn, William C.

“…Abstract Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have few treatment options and continue to have dismal prognoses due to the rapid…”
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Abstract PR03: Subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer by Winter, Peter S., Raghavan, Srivatsan, Navia, Andrew, Williams, Hannah, DenAdel, Alan, Kalekar, Radha, Galvez-Reyes, Jennyfer, Lowder, Kristen, Mulugeta, Nolawit, Raghavan, Manisha, Borah, Ashir, Ng, Raymond, Wang, Junning, Reilly, Emma, Ragon, Dorisanne, Brais, Lauren, Ng, Kimmie, Cleary, James, Crawford, Lorin, Manalis, Scott, Nowak, Jonathan, Wolpin, Brian, Hahn, William, Aguirre, Andrew, Shalek, Alex

“…Abstract The majority of patients with pancreatic ductal adenocarcinoma (PDAC) present at diagnosis with metastatic disease and have median survival times of…”
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Abstract PR02: Matched metastatic pancreatic ductal adenocarcinoma biopsies and organoid models reveal tumor cell transcriptional plasticity and subtype-specific microenvironmental crosstalk by Winter, Peter S., Raghavan, Srivatsan, Navia, Andrew W., Williams, Hannah, Galvez-Reyes, Jennyfer, Kalekar, Radha, Borah, Ashir, DenAdel, Alan, Raghavan, Manisha, Lowder, Kristen, Mulugeta, Nolawit, Wang, Junning, Reilly, Emma, Brais, Lauren, Crawford, Lorin, McFarland, James, Cleary, James M., Nowak, Jonathan, Wolpin, Brian M., Aguirre, Andrew J., Hahn, William C., Shalek, Alex K.

“…Abstract The majority of patients with pancreatic ductal adenocarcinoma (PDAC) present with metastatic disease at diagnosis and have median survival times of…”
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Abstract PO-011: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in SMAD4 or CDH1-deleted cancers by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Kalekar, Radha L., Krill-Burger, Michael J., Dharia, Neekesh V., Kugener, Guillaume, Durbin, Adam D., Yang, Annan, Dumont, Nancy, Li, Yvonne Y., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

“…Abstract Somatic copy number alterations that result in loss of tumor suppressor gene function are important drivers of tumorigenesis. However, few existing…”
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Abstract PO-058: Transcriptional subtype-specific microenvironmental crosstalk and tumor cell plasticity in metastatic pancreatic cancer by Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Kalekar, Radha L., Galvez-Reyes, Jennyfer, Lowder, Kristen E., Mulugeta, Nolawit, Raghavan, Manisha S., Borah, Ashir A., Vayrynen, Sara A., Costa, Andressa Dias, Wang, Junning, Reilly, Emma, Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Cleary, James M., Crawford, Lorin, Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

“…Abstract Metastatic pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy with few therapeutic options. Tumor transcriptional state is…”
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Abstract LB-053: VPS4A is a synthetic lethal target in VPS4B -deficient cancers due to co-deletion with SMAD4 by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Kalekar, Radha L., Krill-Burger, John M., Hong, Andrew L., Kugener, Guillaume, Kalfon, Jeremie, Yang, Annan, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Piccioni, Federica, Wolpin, Brian M., Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

“…Abstract Somatic copy number alterations that result in loss of tumor suppressor gene function are important drivers of tumorigenesis. However, few existing…”
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Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain: e1003966 by Meinke, Gretchen, Phelan, Paul J, Kalekar, Radha, Shin, Jong, Archambault, Jacques, Bohm, Andrew, Bullock, Peter A

“…JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a…”
Get full text