Search Results - "Kaledin, V I"

The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo by Nikolin, V. P., Popova, N. A., Kaledin, V. I., Luzina, O. A., Zakharenko, A. L., Salakhutdinov, N. F., Lavrik, O. I.

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a repair enzyme for 3′-end DNA lesions, predominantly stalled DNA–topoisomerase 1 (Top1) cleavage complexes. Tdp1 is…”
Get full text

Experimental Study of Antitumor Activity of Pefagtal Addressed to αvβ3 Integrins by Popova, N. A., Nikolin, V. P., Kaledin, V. I., Serova, I. A., Matyunina, E. A., Bakarev, M. A., Lushnikova, E. L., Vologodskii, A. N.

“…We studied the effect of a new targeted drug Pefagtal that represents a conjugate in which the MS2 phage filled with a substance toxic to cells (thallium…”
Get full text

Sex-Related Differences in the Sensitivity to Carcinogenic Effect of Urethane on the Lungs in Mice Are Reversed after Neonatal Androgenization by Morozkova, T. S., Kaledin, V. I.

“…Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before…”
Get full text

Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models by Zakharenko, A.L., Luzina, O.A., Sokolov, D.N., Kaledin, V.I., Nikolin, V.P., Popova, N.A., Patel, J., Zakharova, O.D., Chepanova, A.A., Zafar, A., Reynisson, J., Leung, E., Leung, I.K.H., Volcho, K.P., Salakhutdinov, N.F., Lavrik, O.I.

“…The druggability of the tyrosyl-DNA phosphodiesterase 1 (Tdp1) enzyme was investigated in conjunction with topoisomerase 1 inhibition. A novel class of…”
Get full text

Stimulation of Diethylnitrosamine Metabolism Reduces Its General Toxic and Hepatocarcinogenic Effects by Il’nitskaya, S. I., Kaledin, V. I., Bogdanova, L. A., Morozkova, T. S., Kapustina, V. I., Perepechaeva, M. L., Grishanova, A. Yu

“…The general toxic and hepatocarcinogenic effects of diethylnitrosamine after stimulation of its metabolism with 1,4-bis[2-(3,5-dichloropyridyloxy)]-benzene…”
Get full text

Correlation between hepatocarcinogenic effect of estragole and its influence on glucocorticoid induction of liver-specific enzymes and activities of FOXA and HNF4 transcription factors in mouse and rat liver by Kaledin, V. I, Pakharukova, M. Yu, Pivovarova, E. N, Kropachev, K. Yu, Baginskaya, N. V, Vasilieva, E. D, Ilnitskaya, S. I, Nikitenko, E. V, Kobzev, V. F, Merkulova, T. I

“…It is known that the carcinogenic effect of estragole, a component of essential oils of many spicy plants, is characterized by species, tissue, and sex…”
Get full text

Ratio of Active Matrix Metalloproteinases and Proenzymes during Growth and Metastasizing of Mouse Lewis Lung Adenocarcinoma by Kisarova, Ya. A., Kaledin, V. I., Bogdanova, L. A., Korolenko, T. A.

“…Ratio between proMMP and active MMP was studied in the dynamics of growth of the Lewis lung adenocarcinoma with lung metastasis. It was shown that tumor growth…”
Get full text

Hepatocarcinoma-29, a Metastasizing Transplantable Mouse Tumor Inducing Cachexia by Kaledin, V. I, Zhukova, N. A, Nikolin, V. P, Popova, N. A, Beliaev, M. D, Baginskaya, N. V, Litvinova, E. A, Tolstikova, T. G, Lushnikova, E. L, Semenov, D. E

“…Here we describe an experimental tumor, hepatocarcinoma-29: transplantable strain of this tumor is maintained in an ascitic form in СВА/LacYIcgn mice in…”
Get full text

Mutagenic Activation Reduces Carcinogenic Activity of Ortho-Aminoazotoluene for Mouse Liver by Ovchinnikova, L. P., Bogdanova, L. A., Kaledin, V. I.

“…Pentachlorophenol (aromatic amine and azo stain metabolic stimulation inhibitor) reduced the hepatocarcinogenic activity of 4-aminoazobenzene and reduced that…”
Get full text

Immunomodulating Effect of Ethyl Pyruvate on Nonsyngenic Transplanted Tumor in Mice by Bogdanova, L. A., Morozkova, T. S., Kaledin, V. I., Nikolin, V. P., Popova, N. A.

“…Indolamine-2,3-dioxygenase, a tryptophan-catabolizing enzyme, creates local conditions suppressing immune lymphocytes. Expression of this enzyme in tumors…”
Get full text

Antimetastatic Activity of Combined Topotecan and Tyrosyl-DNA Phosphodiesterase-1 Inhibitor on Modeled Lewis Lung Carcinoma by Koldysheva, E. V., Men’shchikova, A. P., Lushnikova, E. L., Popova, N. A., Kaledin, V. I., Nikolin, V. P., Zakharenko, A. L., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.

“…The antimetastatic activity of combined or individual administration of topotecan and tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitor was examined under…”
Get full text

Detection of target genes of FOXA transcription factors involved in proliferation control by Bryzgalov, L. O, Ershov, N. I, Oshchepkov, D. Yu, Kaledin, V. I, Merkulova, T. I

“…To reveal the mechanism of tumor-suppressing activity of FOXA proteins in liver, a search for potential target genes of these transcription factors involved in…”
Get full text

Nitroxyl Antioxidant TPPA-TEMPO Increases the Efficacy of Antitumor Therapy on the Model of Transplantable Mouse Tumor by Kirilyuk, I. A, Kaledin, V. I, Popova, N. A, Nikolin, V. P, Vasil'eva, E. D, Grigor'ev, I. A, Lushnikova, E. L, Nepomnyashchikh, L. M

“…Nitroxyl antioxidant 4-triphenylphosphonioacetamido-2,2,6,6-tetramethylpiperidine-1-oxyl (TPPA-TEMPO) was synthesized from…”
Get full text

Cyclophosphamide metabolite inducing apoptosis in RLS mouse lymphosarcoma cells is a substrate for P-glycoprotein by Patutina, O. A., Mironova, N. L., Logashenko, E. B., Popova, N. A., Nikolin, V. P., Vasil’ev, G. V., Kaledin, V. I., Zenkova, M. A., Vlasov, V. V.

“…RLS lymphosarcoma characterized by enhanced expression of mdr1a and mdr1b genes encoding P-glycoprotein is insensitive to low doses of cyclophosphamide, but is…”
Get full text

OAT and 3’MeDAB Azo Compounds Similarly Cause Liver Tumors in GR Mice, but Differently Modify Activities of FoxA Transcription Factors by Pakharukova, M. Yu, Smetanina, M. A., Ilnitskaya, S. I., Kaledin, V. I., Merkulova, T. I.

“…Transcription factors of the FoxA family (forkhead box A) regulate cell metabolism and differentiation and maintain specificity of liver cell proteome and…”
Get full text

Inhibitor of Indoleamine-2,3-Dioxygenase 1-Methyl-D-Tryptophan Can Stimulate the Growth of Immunogenic Tumors by Vasil’eva, E. D., Nikolin, V. P., Popova, N. A., Lushnikova, E. L., Kaledin, V. I.

“…We studied the effect of 1-methyl-D-tryptophan, an inhibitor of indoleamine-2,3-dioxygenase, on the growth of transplanted hepatocarcinoma-29 in C3HA mice…”
Get full text

Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo by Popova, N. A., Sysoeva, G. M., Nikolin, V. P., Kaledin, V. I., Tretyakov, E. V., Edeeva, M. V., Balakhnin, S. M., Lushnikova, E. L., Audran, G., Mark, S.

“…Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo . In vitro experiments showed that alkoxyamines produce a dose-dependent…”
Get full text

Antimetastatic Effect of Liposomal Recombinant Lactaptin by Kaledin, V. I., Koval, O. A., Kuligina, E. V., Lushnikova, E. L., Nikolin, V. P., Popova, N. A., Pyshnaya, I. A., Richter, V. A.

“…Antimetastatic effect of the liposomal form of recombinant lactaptin RL2 (a proteolytic fragment of human breast milk κ-casein; 8.6 kDa) was studied in A/Sn…”
Get full text

Detection of target genes of FOXA transcription factors involved in proliferation control by Bryzgalov, L O, Ershov, N I, Oshchepkov, D Yu, Kaledin, V I, Merkulova, T I

“…To reveal the mechanism of tumor-suppressing activity of FOXA proteins in liver, a search for potential target genes of these transcription factors involved in…”
Get full text

High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage by Kaledin, V. I., Nikolin, V. P., Popova, N. A., Klinnikova, M. G., Bogdanova, L. A., Morozkova, T. S.

“…Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug…”
Get full text