Search Results - "Kale, Mayur B"
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Interweaving epilepsy and neurodegeneration: Vitamin E as a treatment approach
Published in Biomedicine & pharmacotherapy (01-11-2021)“…Epilepsy is the most common neurological disorder, affecting nearly 50 million people worldwide. The condition can be manifested either due to genetic…”
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Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease
Published in Neurotoxicity research (01-12-2023)“…Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and motor disorders of elderly. Mitochondria are essential for a wide range of…”
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Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases
Published in Current pharmaceutical design (01-01-2024)“…Neurodegenerative disorders are distinguished by the progressive loss of anatomically or physiologically relevant neural systems. Atypical mitochondrial…”
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Involvement of molecular chaperone in protein-misfolding brain diseases
Published in Biomedicine & pharmacotherapy (01-03-2022)“…Protein misfolding causes aggregation and build-up in a variety of brain diseases. There are numeral molecules that are linked with the protein homeostasis…”
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Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
Published in Nutrients (27-08-2023)“…Avenanthramides (Avns) and their derivatives, a group of polyphenolic compounds found abundantly in oats (Avena sativa Linn.), have emerged as promising…”
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Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability
Published in Frontiers in pharmacology (05-09-2024)“…Epilepsy, a complex neurological condition marked by recurring seizures, is increasingly recognized for its intricate relationship with mitochondria, the…”
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Recent Perspectives on Cardiovascular Toxicity Associated with Colorectal Cancer Drug Therapy
Published in Pharmaceuticals (Basel, Switzerland) (01-10-2023)“…Cardiotoxicity is a well-known adverse effect of cancer-related therapy that has a significant influence on patient outcomes and quality of life. The use of…”
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Neurodegenerative disorders associated with genes of mitochondria
Published in Future journal of pharmaceutical sciences (16-03-2021)“…Background Over the last decade, aggregating evidences suggested that there is a causative link between mutation in gene associated with mitochondrial…”
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Agmatine as a novel intervention for Alzheimer's disease: Pathological insights and cognitive benefits
Published in Ageing research reviews (01-04-2024)“…Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and a significant societal burden. Despite…”
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Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats
Published in Brain research bulletin (01-02-2021)“…•Prenatal ethanol exposure impaired cognition and neurological symptoms.•Reduced hippocampal agmatine and BDNF were associated with neurocognitive…”
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Agmatine alleviates ethanol withdrawal-associated cognitive impairment and neurochemical imbalance in rats
Published in Neuroscience letters (29-05-2024)“…The present study aimed to investigate the role of agmatine in the neurobiology underlying memory impairment during ethanol withdrawal in rats. Sprague-Dawley…”
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Modulation of cholesterol metabolism with Phytoremedies in Alzheimer’s disease: A comprehensive review
Published in Ageing research reviews (01-08-2024)“…Alzheimer's disease (AD) is a complex neurological ailment that causes cognitive decline and memory loss. Cholesterol metabolism dysregulation has emerged as a…”
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Navigating the intersection: Diabetes and Alzheimer's intertwined relationship
Published in Ageing research reviews (01-09-2024)“…Alzheimer's disease (AD) and Diabetes mellitus (DM) exhibit comparable pathophysiological pathways. Genetic abnormalities in APP, PS-1, and PS-2 are linked to…”
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Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health
Published in Mitochondrion (01-09-2024)“…•Neuronal development, maturation, and function rely significantly on the essential metabolic functions of mitochondria.•Mitochondrial dysfunction, stemming…”
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Molecular understanding of ER-MT communication dysfunction during neurodegeneration
Published in Mitochondrion (01-09-2023)“…[Display omitted] •Mitochondrial-ER contact sites (MERCS) have received considerable attention in the domain of cell homeostasis and dysfunction, specifically…”
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Phytotherapy: A promising approach for the treatment of Alzheimer's disease
Published in Pharmacological research. Modern Chinese medicine (01-03-2022)“…•Alzheimer's disease is a major neurodegenerative disorder leading to memory loss.•Herbal medicines have shown promising results in preventing Alzheimer's…”
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Mitophagy regulation in aging and neurodegenerative disease
Published in Biophysical reviews (01-04-2023)“…Mitochondria are the primary cellular energy generators, supplying the majority of adenosine triphosphate through oxidative phosphorylation, which is necessary…”
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Alzheimer’s disease and sleep disorders: Insights into the possible disease connections and the potential therapeutic targets
Published in Asian journal of psychiatry (01-02-2022)“…One of the comorbid conditions in an individual with Alzheimer’s disease is a sleep disorder. Clinical features of sleep disorders involve various sleep…”
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AI-driven innovations in Alzheimer's disease: Integrating early diagnosis, personalized treatment, and prognostic modelling
Published in Ageing research reviews (01-11-2024)“…Alzheimer’s disease (AD) presents a significant challenge in neurodegenerative research and clinical practice due to its complex etiology and progressive…”
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