Search Results - "Kale, Andrew J"

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine by Eustáquio, Alessandra S, McGlinchey, Ryan P, Liu, Yuan, Hazzard, Christopher, Beer, Laura L, Florova, Galina, Alhamadsheh, Mamoun M, Lechner, Anna, Kale, Andrew J, Kobayashi, Yoshihisa, Reynolds, Kevin A, Moore, Bradley S

“…Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a…”
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Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib) by Niewerth, Denise, Jansen, Gerrit, Riethoff, Lesley F V, van Meerloo, Johan, Kale, Andrew J, Moore, Bradley S, Assaraf, Yehuda G, Anderl, Janet L, Zweegman, Sonja, Kaspers, Gertjan J L, Cloos, Jacqueline

“…Salinosporamide A (NPI-0052, marizomib) is a naturally occurring proteasome inhibitor derived from the marine actinobacterium Salinispora tropica, and…”
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Molecular Mechanisms of Acquired Proteasome Inhibitor Resistance by Kale, Andrew J., Moore, Bradley S.

“…The development of proteasome inhibitors (PIs) has transformed the treatment of multiple myeloma and mantle cell lymphoma. To date, two PIs have been FDA…”
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Characterization of 5-Chloro-5-Deoxy-d-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis by Kale, Andrew J., McGlinchey, Ryan P., Moore, Bradley S.

“…SalM is a short-chain dehydrogenase/reductase enzyme from the marine actinomycete Salinispora tropica that is involved in the biosynthesis of…”
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The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β-Epoxyketone Warhead from a Marine Cyanobacterium by Pereira, Alban R., Kale, Andrew J., Fenley, Andrew T., Byrum, Tara, Debonsi, Hosana M., Gilson, Michael K., Valeriote, Frederick A., Moore, Bradley S., Gerwick, William H.

“…Two new peptidic proteasome inhibitors were isolated as trace components from a Curaçao collection of the marine cyanobacterium Symploca sp. Carmaphycin A (1)…”
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Bacterial Self-Resistance to the Natural Proteasome Inhibitor Salinosporamide A by Kale, Andrew J, McGlinchey, Ryan P, Lechner, Anna, Moore, Bradley S

“…Proteasome inhibitors have recently emerged as a therapeutic strategy in cancer chemotherapy, but susceptibility to drug resistance limits their efficacy. The…”
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Function-Oriented Biosynthesis of β-Lactone Proteasome Inhibitors in Salinispora tropica by Nett, Markus, Gulder, Tobias A. M, Kale, Andrew J, Hughes, Chambers C, Moore, Bradley S

“…The natural proteasome inhibitor salinosporamide A from the marine bacterium Salinispora tropica is a promising drug candidate for the treatment of multiple…”
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Characterization of 5-Chloro-5-Deoxy-D-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis: SUBSTRATE AND REACTION PROFILING by Kale, Andrew J, McGlinchey, Ryan P, Moore, Bradley S

“…SalM is a short-chain dehydrogenase/reductase enzyme from the marine actinomycete Salinispora tropica that is involved in the biosynthesis of…”
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Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A by Chen, Zeng-Hao, Wang, Bing-Lin, Kale, Andrew J., Moore, Bradley S., Wang, Ruo-Wen, Qing, Feng-Ling

“…Salinosporamide A is an irreversible inhibitor of the β-subunits of the 20S proteasome. Its C-5 cyclohexenyl moiety is the key to its affinity and potency as…”
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Biosynthesis of the Salinosporamide a Polyketide Synthase Substrate Chloroethylmalonyl-Coenzyme a from S-Adenosy-L-Methionine by Eustáquio, Alessandra S., McGlinchey, Ryan P., Liu, Yuan, Hazzard, Christopher, Beer, Laura L., Florova, Galina, Alhamadsheh, Mamoun M., Lechner, Anna, Kale, Andrew J., Kobayashi, Yoshihisa, Reynolds, Kevin A., Moore, Bradley S., Khosla, Chaitan

“…Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a…”
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Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-1-methionine by Eustáquio, Alessandra S, McGlinchey, Ryan P, Liu, Yuan, Hazzard, Christopher, Beer, Laura L, Florova, Galina, Alhamadsheh, Mamoun M, Lechner, Anna, Kale, Andrew J, Kobayashi, Yoshihisa, Reynolds, Kevin A, Moore, Bradley S

“…Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a…”
Get full text