Search Results - "Kaldhusdal, Vilde"
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Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
Published in PLoS pathogens (01-05-2022)“…Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive used by millions of women worldwide. However, experimental studies have…”
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Defining Vaginal Community Dynamics: daily microbiome transitions, the role of menstruation, bacteriophages, and bacterial genes
Published in Microbiome (19-08-2024)“…The composition of the vaginal microbiota during the menstrual cycle is dynamic, with some women remaining eu- or dysbiotic and others transitioning between…”
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Estradiol-mediated enhancement of the human ectocervical epithelial barrier correlates with desmoglein-1 expression in the follicular menstrual phase
Published in Frontiers in endocrinology (Lausanne) (2024)“…The cervicovaginal epithelial barrier is crucial for defending the female reproductive tract against sexually transmitted infections. Hormones, specifically…”
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Distinct cervical tissue-adherent and luminal microbiome communities correlate with mucosal host gene expression and protein levels in Kenyan sex workers
Published in Microbiome (31-03-2023)“…The majority of studies characterizing female genital tract microbiota have focused on luminal organisms, while the presence and impact of tissue-adherent…”
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HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment
Published in Vaccines (Basel) (2021)“…Immunological correlates of natural resistance to HIV have been identified in HIV-exposed seronegative (HESN) individuals and include a low-inflammatory…”
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Sustained immune activation and impaired epithelial barrier integrity in the ectocervix of women with chronic HIV infection
Published in PLoS pathogens (19-11-2024)“…Chronic systemic immune activation significantly influences human immunodeficiency virus (HIV) disease progression. Despite evidence of a pro-inflammatory…”
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Vaginal candida infection is associated with host molecular signatures of neutrophil activation in the adjacent ectocervical mucosa in Kenyan sex workers
Published in American journal of reproductive immunology (1989) (01-02-2024)“…Problem Overgrowth of candida species in the human vaginal mucosa causes inflammation, which could render the mucosal barrier more susceptible to HIV…”
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Preserved Mucosal-Associated Invariant T Cells in the Cervical Mucosa of HIV-Infected Women with Dominant Expression of the TRAV1-2–TRAJ20 T Cell Receptor α-Chain
Published in The Journal of infectious diseases (17-10-2022)“…Abstract Background Mucosa-associated invariant T (MAIT) cells are innate-like T cells with specialized antimicrobial functions. Circulating MAIT cells are…”
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MAIT cells are preserved in the cervical mucosa of HIV-infected women and exhibit a dominant expression of the TRAV1-2-TRAJ20 TCRα chain
Published in The Journal of infectious diseases (02-05-2022)“…MAIT cells are innate-like T cells with specialized antimicrobial functions. Circulating MAIT cells are depleted in chronic HIV infection but studies examining…”
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Assessment of In Vitro and In Silico Protocols for Sequence-Based Characterization of the Human Vaginal Microbiome
Published in mSphere (2020)“…The vaginal microbiome has been connected to a wide range of health outcomes. This has led to a thriving research environment but also to the use of…”
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Assessment of italic toggle="yes">In Vitro /italic> and italic toggle="yes">In Silico /italic> Protocols for Sequence-Based Characterization of the Human Vaginal Microbiome
Published in mSphere (01-12-2020)“…ABSTRACT The vaginal microbiome has been connected to a wide range of health outcomes. This has led to a thriving research environment but also to the use of…”
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Assessment of In Vitro and In Silico Protocols for Sequence-Based Characterization of the Human Vaginal Microbiome (vol 5, e00448-20, 2020)
Published in MSPHERE (01-11-2020)Get full text
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Erratum for Hugerth et al., "Assessment of In Vitro and In Silico Protocols for Sequence-Based Characterization of the Human Vaginal Microbiome"
Published in mSphere (23-12-2020)Get full text
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