Parakeratosis variegata: a possible role of environmental hazards?

We report 2 cases of parakeratosis variegata (PV) evolving from lesions beginning with characteristics of ashy dermatosis. Both patients presented with a reticulated, poikilodermatous and hyperpigmented eruption with bizarre coalescent lichenoid papules. Histology showed lichenoid epidermotropic inf...

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Bibliographic Details
Published in:	Dermatology (Basel) Vol. 201; no. 1; p. 54
Main Authors:	Rogoziński, T T, Zekanowski, C, Kaldan, L, Blaszczyk, M, Majewski, S, Jablońska, S
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-2000
Subjects:	Environmental Exposure - adverse effects Female Fertilizers - adverse effects Humans Insecticides - adverse effects Male Middle Aged Parapsoriasis - etiology Parapsoriasis - pathology Skin - drug effects Skin - pathology
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Summary:	We report 2 cases of parakeratosis variegata (PV) evolving from lesions beginning with characteristics of ashy dermatosis. Both patients presented with a reticulated, poikilodermatous and hyperpigmented eruption with bizarre coalescent lichenoid papules. Histology showed lichenoid epidermotropic infiltrates, more pronounced in case No. 1, consistent with early malignancy. The course was chronic: after more than 10 years, systemic symptoms were not present. In patient No. 1, a monoclonal T-cell population was detected 12 years after the onset of the disease. Both patients had close contact with fertilizers and insecticides. In patient No. 2, the lesions spontaneously regressed within 3 years after cessation of exposure. PV may be a prelymphomatous stage of mycosis fungoides or some closely related cutaneous T-cell lymphoma and does not always evolve into overt malignancy. Gene rearrangement detection techniques may be helpful in predicting the course of the disease.
ISSN:	1018-8665
DOI:	10.1159/000018432