Search Results - "Kalasová, Ilona"

Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient RNA polymerase II-dependent transcription by Sobol, Margarita, Krausová, Alžběta, Yildirim, Sukriye, Kalasová, Ilona, Fáberová, Veronika, Vrkoslav, Vladimír, Philimonenko, Vlada, Marášek, Pavel, Pastorek, Lukáš, Čapek, Martin, Lubovská, Zuzana, Uličná, Lívia, Tsuji, Takuma, Lísa, Miroslav, Cvačka, Josef, Fujimoto, Toyoshi, Hozak, Pavel

“…This paper describes a novel type of nuclear structure - nuclear lipid islets (NLIs). They are of 40-100 nm with a lipidic interior, and phosphatidylinositol…”
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The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication by Hanzlikova, Hana, Kalasova, Ilona, Demin, Annie A., Pennicott, Lewis E., Cihlarova, Zuzana, Caldecott, Keith W.

“…Poly(ADP-ribose) is synthesized by PARP enzymes during the repair of stochastic DNA breaks. Surprisingly, however, we show that most if not all endogenous…”
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Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair by Hanzlikova, Hana, Prokhorova, Evgeniia, Krejcikova, Katerina, Cihlarova, Zuzana, Kalasova, Ilona, Kubovciak, Jan, Sachova, Jana, Hailstone, Richard, Brazina, Jan, Ghosh, Shereen, Cirak, Sebahattin, Gleeson, Joseph G., Ahel, Ivan, Caldecott, Keith W.

“…Neurodegeneration is a common hallmark of individuals with hereditary defects in DNA single-strand break repair; a process regulated by poly(ADP-ribose)…”
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Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome by Fáberová, Veronika, Kalasová, Ilona, Krausová, Alžběta, Hozák, Pavel

“…Phosphoinositides are glycerol-based phospholipids, and they play essential roles in cellular signalling, membrane and cytoskeletal dynamics, cell movement,…”
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Nuclear actin filaments recruit cofilin and actin-related protein 3, and their formation is connected with a mitotic block by Kalendová, Alžběta, Kalasová, Ilona, Yamazaki, Shota, Uličná, Lívia, Harata, Masahiko, Hozák, Pavel

“…Although actin monomers polymerize into filaments in the cytoplasm, the form of actin in the nucleus remains elusive. We searched for the form and function of…”
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Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ by Kalasova, Ilona, Hanzlikova, Hana, Gupta, Neerja, Li, Yun, Altmüller, Janine, Reynolds, John J, Stewart, Grant S, Wollnik, Bernd, Yigit, Gökhan, Caldecott, Keith W

“…To address the relationship between novel mutations in polynucleotide 5'-kinase 3'-phosphatase (PNKP), DNA strand break repair, and neurologic disease. We have…”
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Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair by Kalasova, Ilona, Hailstone, Richard, Bublitz, Janin, Bogantes, Jovel, Hofmann, Winfried, Leal, Alejandro, Hanzlikova, Hana, Caldecott, Keith W

“…Abstract Hereditary mutations in polynucleotide kinase-phosphatase (PNKP) result in a spectrum of neurological pathologies ranging from neurodevelopmental…”
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XRCC1 prevents toxic PARP1 trapping during DNA base excision repair by Demin, Annie A., Hirota, Kouji, Tsuda, Masataka, Adamowicz, Marek, Hailstone, Richard, Brazina, Jan, Gittens, William, Kalasova, Ilona, Shao, Zhengping, Zha, Shan, Sasanuma, Hiroyuki, Hanzlikova, Hana, Takeda, Shunichi, Caldecott, Keith W.

“…Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect…”
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PIP2 epigenetically represses rRNA genes transcription interacting with PHF8 by Ulicna, Livia, Kalendova, Alzbeta, Kalasova, Ilona, Vacik, Tomas, Hozák, Pavel

“…Phosphoinositides are present in the plasma membrane, cytoplasm and inside the cell nucleus. Here we identify phosphatidylinositol-4,5-bisphosphate (PIP2) as a…”
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Corrigendum to “PIP2 epigenetically represses rRNA genes transcription interacting with PHF8” [Biochim. Biophys. Acta Mol. Cell Biol. Volume 1863/3 2017 266-275] by Ulicna, Livia, Kalendova, Alzbeta, Kalasova, Ilona, Vacik, Tomas, Hozák, Pavel

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Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures by Komulainen, Emilia, Badman, Jack, Rey, Stephanie, Rulten, Stuart, Ju, Limei, Fennell, Kate, Kalasova, Ilona, Ilievova, Kristyna, McKinnon, Peter J, Hanzlikova, Hana, Staras, Kevin, Caldecott, Keith W

“…Defects in DNA single-strand break repair (SSBR) are linked with neurological dysfunction but the underlying mechanisms remain poorly understood. Here, we show…”
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Tools for visualization of phosphoinositides in the cell nucleus by Kalasova, Ilona, Fáberová, Veronika, Kalendová, Alžběta, Yildirim, Sukriye, Uličná, Lívia, Venit, Tomáš, Hozák, Pavel

“…Phosphoinositides (PIs) are glycerol-based phospholipids containing hydrophilic inositol ring. The inositol ring is mono-, bis-, or tris-phosphorylated…”
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