Search Results - "Kalaria, Raj"

The pathology and pathophysiology of vascular dementia by Kalaria, Raj N.

“…Vascular dementia (VaD) is widely recognised as the second most common type of dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on…”
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Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease by Kalaria, Raj N.

“…Vascular dementia (VaD) is recognised as a neurocognitive disorder, which is explained by numerous vascular causes in the general absence of other pathologies…”
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Stroke injury, cognitive impairment and vascular dementia by Kalaria, Raj N., Akinyemi, Rufus, Ihara, Masafumi

“…The global burden of ischaemic strokes is almost 4-fold greater than haemorrhagic strokes. Current evidence suggests that 25–30% of ischaemic stroke survivors…”
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Cerebrovascular Disease and Mechanisms of Cognitive Impairment: Evidence From Clinicopathological Studies in Humans by KALARIA, Raj N

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Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia by Duncombe, Jessica, Kitamura, Akihiro, Hase, Yoshiki, Ihara, Masafumi, Kalaria, Raj N, Horsburgh, Karen

“…Increasing evidence suggests that vascular risk factors contribute to neurodegeneration, cognitive impairment and dementia. While there is considerable overlap…”
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Vascular basis for brain degeneration: faltering controls and risk factors for dementia by Kalaria, Raj N

“…The integrity of the vascular system is essential for the efficient functioning of the brain. Aging‐related structural and functional disturbances in the…”
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White matter degeneration in vascular and other ageing‐related dementias by Hase, Yoshiki, Horsburgh, Karen, Ihara, Masafumi, Kalaria, Raj N.

“…Advances in neuroimaging have enabled greater understanding of the progression of cerebral degenerative processes associated with ageing‐related dementias…”
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Does vascular pathology contribute to Alzheimer changes? by Kalaria, Raj N, Akinyemi, Rufus, Ihara, Masafumi

“…Abstract In recent years there has been increased interest in whether vascular disease contributes to Alzheimer's disease (AD). This review considers how…”
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Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia by Akinyemi, Rufus O, Mukaetova-Ladinska, Elizabeta B, Attems, Johannes, Ihara, Masafumi, Kalaria, Raj N

“…Age is the strongest risk factor for brain degeneration whether it results from vascular or neurodegenerative mechanisms or both. To evaluate the current views…”
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Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders by Manzanza, Nelson de Oliveira, Sedlackova, Lucia, Kalaria, Raj N

“…Lewy Body Disorders (LBDs) lie within the spectrum of age-related neurodegenerative diseases now frequently categorized as the synucleinopathies. LBDs are…”
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Top-NOTCH3 Variants in the Population at Large by Kalaria, Raj N., Kittner, Steven J.

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Diabetes, microvascular pathology and Alzheimer disease by Kalaria, Raj N.

“…Epidemiological studies suggest that the risk of developing cognitive impairment and dementia is increased in individuals with diabetes mellitus, although the…”
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Neurodegenerative disease Diabetes, microvascular pathology and Alzheimer disease by Kalaria, Raj N

“…Epidemiological studies suggest that the risk of developing cognitive impairment and dementia is increased in individuals with diabetes mellitus, although the…”
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Update on Vascular Dementia by Khan, Ayesha, Kalaria, Raj N., Corbett, Anne, Ballard, Clive

“…Vascular dementia (VaD) is a major contributor to the dementia syndrome and is described as having problems with reasoning, planning, judgment, and memory…”
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White Matter Changes in Dementia: Role of Impaired Drainage of Interstitial Fluid by Weller, Roy O., Hawkes, Cheryl A., Kalaria, Raj N., Werring, David J., Carare, Roxana O.

“…White matter abnormalities on magnetic resonance imaging (MRI) are associated with dementia and include white matter hyperintensities (WMH; also termed…”
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Dementia: Vascular and neurodegenerative pathways-will they meet? by Kalaria, Raj N, Ihara, Masafumi

“…Loss of brain white matter (WM) is common in the elderly and is associated with cognitive decline and disability.[1,2] Given the heterogeneous nature of brain…”
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Loss of capillary pericytes and the blood–brain barrier in white matter in poststroke and vascular dementias and Alzheimer’s disease by Ding, Ren, Hase, Yoshiki, Ameen‐Ali, Kamar E., Ndung'u, Michael, Stevenson, William, Barsby, Joseph, Gourlay, Ryan, Akinyemi, Tolulope, Akinyemi, Rufus, Uemura, Maiko T., Polvikoski, Tuomo, Mukaetova‐Ladinska, Elizabeta, Ihara, Masafumi, Kalaria, Raj N.

“…White matter (WM) disease is associated with disruption of the gliovascular unit, which involves breach of the blood–brain barrier (BBB). We quantified…”
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The African Dementia Consortium by Akinyemi, Rufus O, Owolabi, Mayowa O, Okubadejo, Njideka, Ogunniyi, Adesola, Kalaria, Raj N

“…[...]many clinicians and biomedical researchers have balked at the idea of exploring ageing-related disorders in sub-Saharan Africa. The APOE ɛ4 allele, which…”
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Neurovascular Ageing and Age-Related Diseases by Kalaria, Raj N, Hase, Yoshiki

“…Proper functioning of the brain is dependent on integrity of the cerebral vasculature. During ageing, a number of factors including aortic or arterial…”
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Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa by Akinyemi, Rufus O., Owolabi, Mayowa O., Ihara, Masafumi, Damasceno, Albertino, Ogunniyi, Adesola, Dotchin, Catherine, Paddick, Stella-Maria, Ogeng’o, Julius, Walker, Richard, Kalaria, Raj N.

“…•Hypertension is the strongest modifiable risk factor for stroke in Africa.•Cerebral SVD appears high among sub-Saharan Africans.•Prevalence estimates of VaD…”
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