Search Results - "Kalams, Spyros A."

OpenCyto: an open source infrastructure for scalable, robust, reproducible, and automated, end-to-end flow cytometry data analysis by Finak, Greg, Frelinger, Jacob, Jiang, Wenxin, Newell, Evan W, Ramey, John, Davis, Mark M, Kalams, Spyros A, De Rosa, Stephen C, Gottardo, Raphael

“…Flow cytometry is used increasingly in clinical research for cancer, immunology and vaccines. Technological advances in cytometry instrumentation are…”
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Characteristics of the earliest cross-neutralizing antibody response to HIV-1 by Mikell, Iliyana, Sather, D Noah, Kalams, Spyros A, Altfeld, Marcus, Alter, Galit, Stamatatos, Leonidas

“…Recent cross-sectional analyses of HIV-1+ plasmas have indicated that broadly cross-reactive neutralizing antibody responses are developed by 10%-30% of HIV-1+…”
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DC-Dielectrophoretic separation of biological cells by size by Kang, Yuejun, Li, Dongqing, Kalams, Spyros A., Eid, Josiane E.

“…DC-Dielectrophoresis (DC-DEP), the induced motion of the dielectric particles in a spatially non-uniform DC electric field, is applied to separate biological…”
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Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson syndrome and toxic epidermal necrolysis by Gibson, Andrew, Ram, Ramesh, Gangula, Rama, Li, Yueran, Mukherjee, Eric, Palubinsky, Amy M., Campbell, Chelsea N., Thorne, Michael, Konvinse, Katherine C., Choshi, Phuti, Deshpande, Pooja, Pedretti, Sarah, Fear, Mark W., Wood, Fiona M., O’Neil, Richard T., Wanjalla, Celestine N., Kalams, Spyros A., Gaudieri, Silvana, Lehloenya, Rannakoe J., Bailin, Samuel S., Chopra, Abha, Trubiano, Jason A., Peter, Jonny G., Mallal, Simon A., Phillips, Elizabeth J.

“…Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening cutaneous drug reaction mediated by human leukocyte antigen…”
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Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV by Currenti, Jennifer, Chopra, Abha, John, Mina, Leary, Shay, McKinnon, Elizabeth, Alves, Eric, Pilkinton, Mark, Smith, Rita, Barnett, Louise, McDonnell, Wyatt J, Lucas, Michaela, Noel, Francine, Mallal, Simon, Conrad, Joseph A, Kalams, Spyros A, Gaudieri, Silvana

“…Human immunodeficiency virus (HIV) can adapt to an individual's T cell immune response via genomic mutations that affect antigen recognition and impact disease…”
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Adaptation to HLA-associated immune pressure over the course of HIV infection and in circulating HIV-1 strains by Alves, Eric, Al-Kaabi, Marwah, Keane, Niamh M, Leary, Shay, Almeida, Coral-Ann M, Deshpande, Pooja, Currenti, Jennifer, Chopra, Abha, Smith, Rita, Castley, Alison, Mallal, Simon, Kalams, Spyros A, Gaudieri, Silvana, John, Mina

“…Adaptation to human leukocyte antigen (HLA)-associated immune pressure represents a major driver of human immunodeficiency virus (HIV) evolution at both the…”
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Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adults by Kalams, Spyros A, Parker, Scott, Jin, Xia, Elizaga, Marnie, Metch, Barbara, Wang, Maggie, Hural, John, Lubeck, Michael, Eldridge, John, Cardinali, Massimo, Blattner, William A, Sobieszczyk, Magda, Suriyanon, Vinai, Kalichman, Artur, Weiner, David B, Baden, Lindsey R

“…DNA vaccines are a promising approach to vaccination since they circumvent the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been…”
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Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV by Bailin, Samuel S, Kropski, Jonathan A, Gangula, Rama D, Hannah, LaToya, Simmons, Joshua D, Mashayekhi, Mona, Ye, Fei, Fan, Run, Mallal, Simon, Warren, Christian M, Kalams, Spyros A, Gabriel, Curtis L, Wanjalla, Celestine N, Koethe, John R

“…Subcutaneous adipose tissue (SAT) is a critical regulator of systemic metabolic homeostasis. Persons with HIV (PWH) have an increased risk of metabolic…”
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Multiparameter analysis of stimulated human peripheral blood mononuclear cells: A comparison of mass and fluorescence cytometry by Nicholas, Katherine J., Greenplate, Allison R., Flaherty, David K., Matlock, Brittany K., Juan, Juan San, Smith, Rita M., Irish, Jonathan M., Kalams, Spyros A.

“…Mass and fluorescence cytometry are quantitative single cell flow cytometry approaches that are powerful tools for characterizing diverse tissues and cellular…”
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CD4 + T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV by Wanjalla, Celestine N, Gabriel, Curtis L, Fuseini, Hubaida, Bailin, Samuel S, Mashayekhi, Mona, Simmons, Joshua, Warren, Christopher M, Glass, David R, Oakes, Jared, Gangula, Rama, Wilfong, Erin, Priest, Stephen, Temu, Tecla, Newell, Evan W, Pakala, Suman, Kalams, Spyros A, Gianella, Sara, Smith, David, Harrison, David G, Mallal, Simon A, Koethe, John R

“…Persons with HIV (PWH) on long-term antiretroviral therapy (ART) have a higher incidence and prevalence of cardiometabolic diseases attributed, in part, to…”
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Tracking of activated cTfh cells following sequential influenza vaccinations reveals transcriptional profile of clonotypes driving a vaccine-induced immune response by Currenti, Jennifer, Simmons, Joshua, Oakes, Jared, Gaudieri, Silvana, Warren, Christian M, Gangula, Rama, Alves, Eric, Ram, Ramesh, Leary, Shay, Armitage, Jesse D, Smith, Rita M, Chopra, Abha, Halasa, Natasha B, Pilkinton, Mark A, Kalams, Spyros A

“…A vaccine against influenza is available seasonally but is not 100% effective. A predictor of successful seroconversion in adults is an increase in activated…”
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Adipose Tissue in Persons With HIV Is Enriched for CD4 + T Effector Memory and T Effector Memory RA + Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance by Wanjalla, Celestine N, McDonnell, Wyatt J, Barnett, Louise, Simmons, Joshua D, Furch, Briana D, Lima, Morgan C, Woodward, Beverly O, Fan, Run, Fei, Ye, Baker, Paxton G, Ram, Ramesh, Pilkinton, Mark A, Mashayekhi, Mona, Brown, Nancy J, Mallal, Simon A, Kalams, Spyros A, Koethe, John R

“…Chronic T cell activation and accelerated immune senescence are hallmarks of HIV infection, which may contribute to the increased risk of cardiometabolic…”
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Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8 + T Cell Functionality: An Alternative Viral Adaptation Strategy by Currenti, Jennifer, Law, Becker M P, Qin, Kai, John, Mina, Pilkinton, Mark A, Bansal, Anju, Leary, Shay, Ram, Ramesh, Chopra, Abha, Gangula, Rama, Yue, Ling, Warren, Christian, Barnett, Louise, Alves, Eric, McDonnell, Wyatt J, Sooda, Anuradha, Heath, Sonya L, Mallal, Simon, Goepfert, Paul, Kalams, Spyros A, Gaudieri, Silvana

“…Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another…”
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Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth by Chukwuma, Valentine U, Kose, Nurgun, Sather, D Noah, Sapparapu, Gopal, Falk, Rachel, King, Hannah, Singh, Vidisha, Lampley, Rebecca, Malherbe, Delphine C, Ditto, Noah T, Sullivan, Jonathan T, Barnes, Trevor, Doranz, Benjamin J, Labranche, Celia C, Montefiori, David C, Kalams, Spyros A, Haigwood, Nancy L, Crowe, Jr, James E

“…Broadly neutralizing antibodies (bNAbs) are rarely elicited by current human immunodeficiency virus type 1 (HIV-1) vaccine designs, but the presence of bNAbs…”
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Cellular Recognition of Mycobacterium tuberculosis ESAT-6 and KatG Peptides in Systemic Sarcoidosis by Drake, Wonder P, Dhason, Mary S, Nadaf, Michele, Shepherd, Bryan E, Vadivelu, Sangeetha, Hajizadeh, Rana, Newman, Lee S, Kalams, Spyros A

“…Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6…”
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Leptin Promotes Greater Ki67 Expression in CD4 + T Cells From Obese Compared to Lean Persons Living With HIV by Fuseini, Hubaida, Smith, Rita, Nochowicz, Cindy H, Simmons, Joshua D, Hannah, LaToya, Wanjalla, Celestine N, Gabriel, Curtis L, Mashayekhi, Mona, Bailin, Samuel S, Castilho, Jessica L, Hasty, Alyssa H, Koethe, John R, Kalams, Spyros A

“…While antiretroviral therapy (ART) has proven effective in suppressing viremia and disease progression among people living with human immunodeficiency virus…”
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B cell responses to HIV antigen are a potent correlate of viremia in HIV-1 infection and improve with PD-1 blockade by Nicholas, Katherine J, Zern, Emily K, Barnett, Louise, Smith, Rita M, Lorey, Shelly L, Copeland, Courtney A, Sadagopal, Shanmugalakshmi, Kalams, Spyros A

“…Infection with Human Immunodeficiency Virus Type 1 (HIV-1) induces defects of both cellular and humoral immune responses. Impaired CD4+ T cell help and B cell…”
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Increased Frequency of Regulatory T Cells and T Lymphocyte Activation in Persons with Previously Treated Extrapulmonary Tuberculosis by de Almeida, Alexandre S, Fiske, Christina T, Sterling, Timothy R, Kalams, Spyros A

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis by Barreto-Duarte, Beatriz, Sterling, Timothy R, Fiske, Christina T, Almeida, Alexandre, Nochowicz, Cynthia H, Smith, Rita M, Barnett, Louise, Warren, Christian, Blackman, Amondrea, Lapa E Silva, Jose Roberto, Andrade, Bruno B, Kalams, Spyros A

“…Extrapulmonary TB (EPTB) occurs with increased frequency in persons with underlying immunodeficiency. Even after recovery from acute illness, differences in…”
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Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy by Lhomme, Edouard, Richert, Laura, Moodie, Zoe, Pasin, Chloé, Kalams, Spyros A, Morgan, Cecilia, Self, Steve, De Rosa, Stephen C, Thiébaut, Rodolphe

“…Initial evaluation of a candidate vaccine against HIV includes an assessment of the vaccine's ability to generate immune responses. However, the dynamics of…”
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