Search Results - "Kalabis, Jiri"
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Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture
Published in Nature protocols (01-02-2012)“…This protocol describes the isolation and characterization of mouse and human esophageal epithelial cells and the application of 3D organotypic culture (OTC),…”
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Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors
Published in Cancer research (Chicago, Ill.) (15-05-2010)“…Transforming growth factor-beta (TGF-beta) is a potent inducer of epithelial to mesenchymal transition (EMT). However, it remains elusive about which molecular…”
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CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1
Published in The Journal of cell biology (20-11-2006)“…Melanocytes reside within the basal layer of the human epidermis, where they attach to the basement membrane and replicate at a rate proportionate to that of…”
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Vangl1 Protein Acts as a Downstream Effector of Intestinal Trefoil Factor (ITF)/TFF3 Signaling and Regulates Wound Healing of Intestinal Epithelium
Published in The Journal of biological chemistry (10-03-2006)“…The intestinal trefoil factor (ITF/TFF3) protects intestinal epithelia from a range of insults and contributes to mucosal repair. However, the signaling events…”
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Reciprocal regulation of MelCAM and AKT in human melanoma
Published in Oncogene (09-10-2003)“…Alteration in the expression of invasion/metastasis-related melanoma cell adhesion molecule (MelCAM) is strongly associated with the acquisition of malignancy…”
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Stimulation of human colonic epithelial cells by leukemia inhibitory factor is dependent on collagen‐embedded fibroblasts in organotypic culture
Published in The FASEB journal (01-06-2003)“…ABSTRACT The colonic epithelium undergoes a continuous cycle of proliferation, differentiation, and apoptosis. To characterize factors important for colonic…”
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Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene
Published in Cancer cell (12-04-2011)“…p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged…”
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IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2
Published in Cancer research (Chicago, Ill.) (15-03-2011)“…Insulin-like growth factor 2 mRNA-binding protein-1 (IMP-1) is an oncofetal protein that binds directly to and stabilizes oncogenic c-Myc and regulates, in…”
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The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation
Published in Genes & development (01-11-2007)“…Esophageal cancer is a prototypic squamous cell cancer that carries a poor prognosis, primarily due to presentation at advanced stages. We used human…”
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A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification
Published in The Journal of clinical investigation (01-12-2008)“…The esophageal epithelium is a prototypical stratified squamous epithelium that exhibits an exquisite equilibrium between proliferation and differentiation…”
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Endothelin-3 stimulates survival of goblet cells in organotypic cultures of fetal human colonic epithelium
Published in American journal of physiology: Gastrointestinal and liver physiology (01-12-2008)“…Cells within the normal human colonic epithelium undergo a dynamic cycle of growth, differentiation, and death. The organotypic culture system of human fetal…”
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Abstract A3: Facilitating epithelial to mesenchymal transition through inhibition of senescence checkpoint functions
Published in Cancer research (Chicago, Ill.) (01-12-2009)“…Transforming growth factor (TGF)-β is a potent inducer of epithelial to mesenchymal transition (EMT). However, EMT is not a sole consequence of TGF-β mediated…”
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IMP-1 displays crosstalk with K-Ras and modulates colon cancer cell survival through the novel pro-apoptotic protein CYFIP2
Published in Cancer research (Chicago, Ill.) (20-01-2011)“…Insulin-like growth factor 2 mRNA-binding protein-1 (IMP-1) is an oncofetal protein that binds directly to and stabilizes oncogenic c-Myc and regulates in turn…”
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Abstract C29: Periostin, a regulator of adhesion, is a novel effector of tumor invasion
Published in Cancer research (Chicago, Ill.) (01-12-2009)“…Squamous cell cancers in aggregate comprise the most common forms of epithelial cancers, arising from the skin, head/neck, oral cavity, esophagus, lung and…”
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EGFR and mutant p53 expand esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors
Published in Cancer research (Chicago, Ill.) (27-04-2010)“…Transforming growth factor (TGF)-β is a potent inducer of epithelial to mesenchymal transition (EMT). However, it remains elusive as to which molecular…”
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EGFR and Notch Determine Esophageal Cell Fates Through an Antagonistic Crosstalk
Published in Gastroenterology (New York, N.Y. 1943) (2011)Get full text
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Colon carcinoma cells induce CXCL11-dependent migration of CXCR3-expressing cytotoxic T lymphocytes in organotypic culture
Published in Cancer Immunology, Immunotherapy (01-03-2007)“…Adoptive immunotherapy of cancer patients with cytolytic T lymphocytes (CTL) has been hampered by the inability of the CTL to home into tumors in vivo…”
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