Search Results - "Kakuta, Masayo"

Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration by KUBO, Shuku, TOMOZAWA, Takanori, KAKUTA, Masayo, TOKUMITSU, Akane, YAMASHITA, Makoto

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CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity by YAMASHITA, Makoto, TOMOZAWA, Takanori, KAKUTA, Masayo, TOKUMITSU, Akane, NASU, Hatsumi, KUBO, Shuku

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Renadirsen, a Novel 2′OMeRNA/ENA® Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo by Ito, Kentaro, Takakusa, Hideo, Kakuta, Masayo, Kanda, Akira, Takagi, Nana, Nagase, Hiroyuki, Watanabe, Nobuaki, Asano, Daigo, Goda, Ryoya, Masuda, Takeshi, Nakamura, Akifumi, Onishi, Yoshiyuki, Onoda, Toshio, Koizumi, Makoto, Takeshima, Yasuhiro, Matsuo, Masafumi, Takaishi, Kiyosumi

“…Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by out-of-frame or nonsense mutation in the dystrophin gene. It begins with a…”
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Efficacy of a single intravenous administration of laninamivir (an active metabolite of laninamivir octanoate) in an influenza virus infection mouse model by Kakuta, Masayo, Kubo, Shuku, Tanaka, Mikiko, Tobiume, Satoko, Tomozawa, Takanori, Yamashita, Makoto

“…•All NA inhibitors were administered once intravenously to examine in vivo efficacy.•The efficacy was assessed in an influenza A and B viruses infection mouse…”
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Potent In Vitro Activity of Tomopenem (CS-023) against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa by KOGA, Tetsufumi, MASUDA, Nobuhisa, KAKUTA, Masayo, NAMBA, Eiko, SUGIHARA, Chika, FUKUOKA, Takashi

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High and continuous exposure of laninamivir, an anti-influenza drug, may work suppressively to generate low-susceptibility mutants in animals by Kubo, Shuku, Tokumitsu, Akane, Tomozawa, Takanori, Kakuta, Masayo, Yamashita, Makoto

“…Abstract Laninamivir octanoate (Inavir® ; Daiichi Sankyo, Tokyo, Japan) is an anti-influenza drug that provides complete treatment by a single inhalation. It…”
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In Vivo Pharmacodynamic Activity of Tomopenem (formerly CS-023) against Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus in a Murine Thigh Infection Model by SUGIHARA, Kiyoshi, SUGIHARA, Chika, KOGA, Tetsufumi, MATSUSHITA, Yoko, YAMAMURA, Naotoshi, UEMORI, Mitsutoshi, TOKUMITSU, Akane, INOUE, Harumi, KAKUTA, Masayo, NAMBA, Eiko, NASU, Hatsumi

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Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by KOGA, Tetsufumi, SUGIHARA, Chika, KAKUTA, Masayo, MASUDA, Nobuhisa, NAMBA, Eiko, FUKUOKA, Takashi

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In Vitro and In Vivo Antibacterial Activities of CS-023 (RO4908463), a Novel Parenteral Carbapenem by KOGA, Tetsufumi, ABE, Tomomi, SHIBAYAMA, Takahiro, MATSUSHITA, Yoko, HIROTA, Takashi, OHYA, Satoshi, UTSUI, Yukio, FUKUOKA, Takashi, KUWAHARA, Syogo, INOUE, Harumi, TAKENOUCHI, Takashi, KITAYAMA, Akiko, YOSHIDA, Tatsuhiko, MASUDA, Nobuhisa, SUGIHARA, Chika, KAKUTA, Masayo, NAKAGAWA, Miyuki

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Antifungal Activities of R-135853, a Sordarin Derivative, in Experimental Candidiasis in Mice by KAMAI, Yasuki, KAKUTA, Masayo, SHIBAYAMA, Takahiro, FUKUOKA, Takashi, KUWAHARA, Shogo

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A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T by Ito, Kentaro, Tajima, Go, Kamisato, Chikako, Tsumura, Miyuki, Iwamoto, Mitsuhiro, Sekiguchi, Yukiko, Numata, Yukinobu, Watanabe, Kyoko, Yabe, Yoshiyuki, Kanki, Satomi, Fujieda, Yusuke, Goto, Koichi, Sogawa, Yoshitaka, Oitate, Masataka, Nagase, Hiroyuki, Tsuji, Shinnosuke, Nishizawa, Tomohiro, Kakuta, Masayo, Masuda, Takeshi, Onishi, Yoshiyuki, Koizumi, Makoto, Nakamura, Hidefumi, Okada, Satoshi, Matsuo, Masafumi, Takaishi, Kiyosumi

“…Glycogen storage disease type 1a (GSD1a) is caused by a congenital deficiency of glucose-6-phosphatase-α (G6Pase-α, encoded by G6PC), which is primarily…”
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A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648GT by Ito, Kentaro, Tajima, Go, Kamisato, Chikako, Tsumura, Miyuki, Iwamoto, Mitsuhiro, Sekiguchi, Yukiko, Numata, Yukinobu, Watanabe, Kyoko, Yabe, Yoshiyuki, Kanki, Satomi, Fujieda, Yusuke, Goto, Koichi, Sogawa, Yoshitaka, Oitate, Masataka, Nagase, Hiroyuki, Tsuji, Shinnosuke, Nishizawa, Tomohiro, Kakuta, Masayo, Masuda, Takeshi, Onishi, Yoshiyuki, Koizumi, Makoto, Nakamura, Hidefumi, Okada, Satoshi, Matsuo, Masafumi, Takaishi, Kiyosumi

“…Glycogen storage disease type 1a (GSD1a) is caused by a congenital deficiency of glucose-6-phosphatase-[alpha] (G6Pase-[alpha], encoded by G6PC), which is…”
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Renadirsen, a Novel 2'OMeRNA/ENA ® Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo by Ito, Kentaro, Takakusa, Hideo, Kakuta, Masayo, Kanda, Akira, Takagi, Nana, Nagase, Hiroyuki, Watanabe, Nobuaki, Asano, Daigo, Goda, Ryoya, Masuda, Takeshi, Nakamura, Akifumi, Onishi, Yoshiyuki, Onoda, Toshio, Koizumi, Makoto, Takeshima, Yasuhiro, Matsuo, Masafumi, Takaishi, Kiyosumi

“…Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by out-of-frame or nonsense mutation in the dystrophin gene. It begins with a…”
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In-vitro activity of panipenem against clinical isolates in 2006 by Yoshida, Sanae, Koga, Tetsufumi, Kakuta, Masayo, Kobayashi, Intetsu, Matsuzaki, Kaoru, Urabe, Eriko, Omika, Kaoru, Hasegawa, Miyuki, Sato, Yumie

“…The antimicrobial activity of various antibiotics against clinical bacterial isolates recovered from patients with infectious diseases at the medical…”
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Absorption, elimination, and metabolism of CS-1036, a novel α-amylase inhibitor in rats and monkeys, and the relationship between gastrointestinal distribution and suppression of glucose absorption by Honda, Tomohiro, Kaneno-Urasaki, Yoko, Murai, Takahiro, Kakuta, Masayo, Nasu, Hatsumi, Namba, Eiko, Koga, Tetsufumi, Okuno, Akira, Izumi, Takashi

“…The absorption, metabolism, and excretion of (2R,3R,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-3-yl 4-O-(6-deoxy-β-d-glucopyranosyl)-α-d-glucopyranoside…”
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Rapid bactericidal activities of carbapenems against Pseudomonas aeruginosa in simulating human plasma concentrations by Ishii, Chika, Kakuta, Masayo, Abe, Tomomi, Fukuoka, Takashi, Inoue, Matsuhisa

“…The rapid bactericidal activities of panipenem (PAPM), imipenem (IPM), and meropenem (MEPM) against Pseudomonas aeruginosa were investigated by using in vitro…”
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In vitro postantibiotic effects of tomopenem (CS-023) against Staphylococcus aureus and Pseudomonas aeruginosa by TOMOZAWA, Takanori, SUGIHARA, Chika, KAKUTA, Masayo, SUGIHARA, Kiyoshi, KOGA, Tetsufumi

“…The postantibiotic effect (PAE) of tomopenem was determined after a 2 h exposure of two strains of meticillin-susceptible and meticillin-resistant…”
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In vitro and in vivo effects of a long-acting anti-influenza agent CS-8958 (laninamivir octanoate, Inavir) against pandemic (H1N1) 2009 influenza viruses by Kubo, Shuku, Kakuta, Masayo, Yamashita, Makoto

“…Laninamivir is a novel neuraminidase inhibitor of influenza viruses and it has been reported that its prodrug, CS-8958 shows a long-lasting characteristics…”
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Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare in vitro and in vivo by Koga, Tetsufumi, Fukuoka, Takashi, Doi, Norio, Harasaki, Tamako, Inoue, Harumi, Hotoda, Hitoshi, Kakuta, Masayo, Muramatsu, Yasunori, Yamamura, Naotoshi, Hoshi, Misa, Hirota, Takashi

“…Objectives: The antimycobacterial activities of RS-112997, RS-124922 and RS-118641, three capuramycin analogues that inhibit…”
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Combination effect of teicoplanin and panipenem on highly resistant strains of MRSA by Utsui, Y, Ishii, C, Abe, T, Kakuta, M, Ohya, S

“…We investigated the in vitro combination effect of teicoplanin (TEIC) and panipenem (PAPM) on highly oxacillin-resistant strains of Staphylococcus aureus…”
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