Search Results - "Kakizuka, A."

Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine by Maeda, H, Hori, S, Ohizumi, H, Segawa, T, Kakehi, Y, Ogawa, O, Kakizuka, A

“…Clinical application of anticancer agents has been often hampered by toxicity against normal cells, so the achievement of their cancer-specific action is still…”
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VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration by Hirabayashi, M, Inoue, K, Tanaka, K, Nakadate, K, Ohsawa, Y, Kamei, Y, Popiel, A H, Sinohara, A, Iwamatsu, A, Kimura, Y, Uchiyama, Y, Hori, S, Kakizuka, A

“…Neuronal cell death, abnormal protein aggregates, and cytoplasmic vacuolization are major pathologies observed in many neurodegenerative disorders such as the…”
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The small GTP‐binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase by Ishizaki, T., Maekawa, M., Fujisawa, K., Okawa, K., Iwamatsu, A., Fujita, A., Watanabe, N., Saito, Y., Kakizuka, A., Morii, N., Narumiya, S.

“…The small GTP‐binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers, cytokinesis and transcriptional…”
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Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration by Higashiyama, H, Hirose, F, Yamaguchi, M, Inoue, Y H, Fujikake, N, Matsukage, A, Kakizuka, A

“…We have successfully generated a Drosophila model of human polyglutamine (polyQ) diseases by the targeted expression of expanded-polyQ (ex-polyQ) in the…”
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cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla by NAMBA, T, OIDA, H, SUGIMOTO, Y, KAKIZUKA, A, NEGISHI, M, ICHIKAWA, A, NARUMIYA, S

“…A functional cDNA for a mouse prostacyclin receptor was isolated from a mouse cDNA library by reverse transcription polymerase chain reaction and hybridization…”
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Cloning and expression of a cDNA for mouse prostaglandin F receptor by SUGIMOTO, Y, HASUMOTO, K.-Y, NAMBA, T, IRIE, A, KATSUYAMA, M, NEGISHI, M, KAKIZUKA, A, NARUMIYA, S, ICHIKAWA, A

“…A functional cDNA clone for mouse prostaglandin (PG) F receptor was isolated from a mouse cDNA library using polymerase chain reaction based on the sequence of…”
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Cdc25M2 Activation of Cyclin-Dependent Kinases by Dephosphorylation of Threonine-14 and Tyrosine-15 by Sebastian, Byron, Kakizuka, Akira, Hunter, Tony

“…Recent evidence has suggested that human cyclin-dependent kinase 2 (CDK2) is an essential regulator of cell cycle progression through S phase. CDK2 is known to…”
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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML by Kakizuka, A, Miller, Jr, W H, Umesono, K, Warrell, Jr, R P, Frankel, S R, Murty, V V, Dmitrovsky, E, Evans, R M

“…A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor…”
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Molecular Characterization of a Mouse Prostaglandin D Receptor and Functional Expression of the Cloned Gene by Hirata, Masakazu, Kakizuka, Akira, Aizawa, Megumi, Ushikubi, Fumitaka, Narumiya, Shuh

“…Prostanoid receptors belong to the family of G protein-coupled receptors with seven transmembrane domains. By taking advantage of nucleotide sequence homology…”
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Molecular analyses of Machado-Joseph disease by Kobayashi, T, Kakizuka, A

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Molecular characterization of a functional cDNA for rat substance P receptor by Yokota, Y, Sasai, Y, Tanaka, K, Fujiwara, T, Tsuchida, K, Shigemoto, R, Kakizuka, A, Ohkubo, H, Nakanishi, S

“…This paper describes the amino acid sequence of the rat substance P receptor and its comparison with that of the rat substance K receptor on the basis of…”
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Molecular features of the CAG repeats and clinical manifestation of Machado-Joseph disease by Maruyama, H, Nakamura, S, Matsuyama, Z, Sakai, T, Doyu, M, Sobue, G, Seto, M, Tsujihata, M, Oh-i, T, Nishio, T

“…Machado--Joseph disease (MJD) is an autosomal dominant spinocerebellar degeneration mapped to chromosome 14q32.1. The CAG expansions of the MJD1 gene was…”
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Isolation of neuronal cells with high processing activity for the Machado-Joseph disease protein by Yamamoto, Y, Hasegawa, H, Tanaka, K, Kakizuka, A

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Degenerative ataxias: genetics, pathogenesis and animal models by Kakizuka, A

“…At present, seven inherited neurodegenerative disorders have been identified to be caused by the polyglutamine-coding CAG triplet expansions in the genes…”
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Reverse Transcription Polymerase Chain Reaction for the Rearranged Retinoic Acid Receptor α Clarifies Diagnosis and Detects Minimal Residual Disease in Acute Promyelocytic Leukemia by Miller, Wilson H., Kakizuka, Akira, Frankel, Stanley R., Warrell, Raymond P., DeBlasio, Anthony, Levine, Kristi, Evans, Ronald M., Dmitrovsky, Ethan

“…The characteristic t(15;17) of acute promyelocytic leukemia (APL) fuses the retinoic acid receptor α (RAR-α) gene on chromosome 17 to a gene on chromosome 15…”
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Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases by Tsurumi, Chizuko, Ishida, Naruhiro, Tamura, Tomohiro, Kakizuka, Akira, Nishida, Eisuke, Okumura, Eiichi, Kishimoto, Takeo, Inagaki, Masaki, Okazaki, Kenji, Sagata, Noriyuki, Ichihara, Akira, Tanaka, Keiji

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Alteration of a single amino acid residue in retinoic acid receptor causes dominant-negative phenotype by SAITOU, M, NARUMIYA, S, KAKIZUKA, A

“…Thyroid hormone receptor (TR) and retinoic acid receptor (RAR) are closely related not only in their structures but also in their modes of action. TR and RAR…”
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Characterization and chromosomal mapping of the human thromboxane A2 receptor gene by Nüsing, R M, Hirata, M, Kakizuka, A, Eki, T, Ozawa, K, Narumiya, S

“…The human thromboxane A2 gene, present as a single copy, spans over 15 kilobases (kb) and contains 3 exons divided by 2 introns. The first intron, intron 1,…”
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Structure of the retinoic acid receptor and its functional analysis using a mutated receptor by Kakizuka, A

“…RA shows a variety of actions including the teratogenicity at pharmacological doses, but its physiological roles remain unclear. Recently, receptors for RA,…”
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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats by Nishitoh, Hideki, Matsuzawa, Atsushi, Tobiume, Kei, Saegusa, Kaoru, Takeda, Kohsuke, Inoue, Kiyoshi, Hori, Seiji, Kakizuka, Akira, Ichijo, Hidenori

“…Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause of at least nine inherited human neurodegenerative disorders,…”
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