Search Results - "Kakimoto, Shuichiro"

Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect by Watabiki, Tomonari, Kiso, Tetsuo, Kuramochi, Takahiro, Yonezawa, Koichi, Tsuji, Noriko, Kohara, Atsuyuki, Kakimoto, Shuichiro, Aoki, Toshiaki, Matsuoka, Nobuya

“…Transient receptor potential vanilloid 1 (TRPV1) is activated by a variety of stimulations, such as endogenous ligands and low pH, and is believed to play a…”
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Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X2/3 receptor function and exerts an analgesic effect in pain models by Kakimoto, Shuichiro, Nagakura, Yukinori, Tamura, Seiji, Watabiki, Tomonari, Shibasaki, Kumiko, Tanaka, Shohei, Mori, Masamichi, Sasamata, Masao, Okada, Masamichi

“…The P2X2/3 receptor has an important role in the nociceptive transmission. Minodronic acid is a third third-generation bisphosphonate and a potent inhibitor of…”
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Analgesic effects of ASP3662, a novel 11β‐hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain by Kiso, Tetsuo, Sekizawa, Toshihiro, Uchino, Hiroshi, Tsukamoto, Mina, Kakimoto, Shuichiro

“…Background and Purpose Glucocorticoids are a major class of stress hormones known to participate in stress‐induced hyperalgesia. Although 11β‐hydroxysteroid…”
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A novel GABAB receptor positive allosteric modulator, ASP8062, exerts analgesic effects in a rat model of fibromyalgia by Murai, Nobuhito, Kondo, Yuji, Akuzawa, Shinobu, Mihara, Takuma, Shiraishi, Nobuyuki, Kakimoto, Shuichiro, Matsumoto, Mitsuyuki

“…The gamma-aminobutyric acid type B (GABAB) receptor agonist, the sodium salt of gamma-hydroxybutyrate (GHB), significantly improved pain, sleep disturbance and…”
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Analgesic effects of ASP 3662, a novel 11β‐hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain by Kiso, Tetsuo, Sekizawa, Toshihiro, Uchino, Hiroshi, Tsukamoto, Mina, Kakimoto, Shuichiro

“…Background and Purpose Glucocorticoids are a major class of stress hormones known to participate in stress‐induced hyperalgesia. Although 11β‐hydroxysteroid…”
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In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor by Watabiki, Tomonari, Tsuji, Noriko, Kiso, Tetsuo, Ozawa, Tohru, Narazaki, Fumie, Kakimoto, Shuichiro

“…Although exogenous agonists for cannabinoid (CB) receptors are clinically effective for treating chronic pain, global activation of brain CB receptors causes…”
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A [K.sub.Ca]3.l Channel Opener, ASP08I9, Modulates Nociceptive Signal Processing from Peripheral Nerves in Fibromyalgia-Like Pain in Rats by Takeshita, Nobuaki, Oe, Tomoya, Kiso, Tetsuo, Kakimoto, Shuichiro

“…Purpose: Although abnormal peripheral and central pain processing has been observed in fibromyalgia (FM) patients, the biomechanics and pathophysiology,…”
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A K Ca 3.1 Channel Opener, ASP0819, Modulates Nociceptive Signal Processing from Peripheral Nerves in Fibromyalgia-Like Pain in Rats by Takeshita, Nobuaki, Oe, Tomoya, Kiso, Tetsuo, Kakimoto, Shuichiro

“…Although abnormal peripheral and central pain processing has been observed in fibromyalgia (FM) patients, the biomechanics and pathophysiology, surrounding the…”
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Spontaneous and evoked pain-associated behaviors in a rat model of neuropathic pain respond differently to drugs with different mechanisms of action by Murai, Nobuhito, Sekizawa, Toshihiro, Gotoh, Takayasu, Watabiki, Tomonari, Takahashi, Masayasu, Kakimoto, Shuichiro, Takahashi, Yuko, Iino, Masanobu, Nagakura, Yukinori

“…Given that patients with neuropathic pain suffer a mixture of spontaneous and evoked pain symptoms, we assessed the effects of drugs with different mechanism…”
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Gene mutation in hereditary progressive dystonia with marked diurnal fluctuation (HPD), strictly defined dopa-responsive dystonia by Nishiyama, Nobuyoshi, Yukishita, Shoko, Hagiwara, Hiroaki, Kakimoto, Shuichiro, Nomura, Yoshiko, Segawa, Masaya

“…Mutations of the guanosine triphosphate (GTP)-cyclohydrolase I (GCH-I) gene, which catalyzes the first step in the tetrahydrobiopterin (the natural cofactor…”
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Antiemetic Effects of Morphine on Motion- and Drug-Induced Emesis in Suncus murinus by KAKIMOTO, Shuichiro, SAITO, Hiroshi, MATSUKI, Norio

“…Emetic and antiemetic effects of morphine were investigated in Suncus murinus. Subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 μg)…”
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A KCa3.1 Channel Opener, ASP0819, Modulates Nociceptive Signal Processing from Peripheral Nerves in Fibromyalgia-Like Pain in Rats by Takeshita, Nobuaki, Oe, Tomoya, Kiso, Tetsuo, Kakimoto, Shuichiro

“…Purpose: Although abnormal peripheral and central pain processing has been observed in fibromyalgia (FM) patients, the biomechanics and pathophysiology,…”
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Involvement of a Peripheral Mechanism in the Emesis Induced by Cardiac Glycosides in Suncus murinus by KAKIMOTO, Shuichiro, SAITO, Hiroshi, MATSUKI, Norio

“…The ability of three cardiac glycosides, ouabain, digitonin and digitoxin, to induce emesis and their mechanism(s) of action were investigated n Suncus…”
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AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover by Murai, Nobuhito, Aoki, Toshiaki, Tamura, Seiji, Sekizawa, Toshihiro, Kakimoto, Shuichiro, Tsukamoto, Mina, Oe, Tomoya, Enomoto, Ryugo, Hamakawa, Nozomu, Matsuoka, Nobuya

“…AS1069562 [(R)-2-[(1H-inden-7-yloxy)methyl]morpholine monobenzenesulfonate] is the (+)-isomer of indeloxazine, which had been used clinically for the treatment…”
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Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability by Ogiyama, Takashi, Yonezawa, Koichi, Inoue, Makoto, Katayama, Naoko, Watanabe, Toshihiro, Yoshimura, Seiji, Gotoh, Takayasu, Kiso, Tetsuo, Koakutsu, Akiko, Kakimoto, Shuichiro, Shishikura, Jun-ichi

“…[Display omitted] In lead optimization efforts starting from the tetrahydroisoquinoline (S)-1, we identified…”
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Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain by Ogiyama, Takashi, Yonezawa, Koichi, Inoue, Makoto, Watanabe, Toshihiro, Sugano, Yukihito, Gotoh, Takayasu, Kiso, Tetsuo, Koakutsu, Akiko, Kakimoto, Shuichiro, Shishikura, Jun-ichi

“…[Display omitted] N-type calcium channel blockade is a promising therapeutic approach for the treatment of neuropathic pain. Starting from lead compound (S)-1,…”
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A novel GABA B receptor positive allosteric modulator, ASP8062, exerts analgesic effects in a rat model of fibromyalgia by Murai, Nobuhito, Kondo, Yuji, Akuzawa, Shinobu, Mihara, Takuma, Shiraishi, Nobuyuki, Kakimoto, Shuichiro, Matsumoto, Mitsuyuki

“…The gamma-aminobutyric acid type B (GABA ) receptor agonist, the sodium salt of gamma-hydroxybutyrate (GHB), significantly improved pain, sleep disturbance and…”
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Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels by Ogiyama, Takashi, Inoue, Makoto, Honda, Shugo, Yamada, Hiroyoshi, Watanabe, Toshihiro, Gotoh, Takayasu, Kiso, Tetsuo, Koakutsu, Akiko, Kakimoto, Shuichiro, Shishikura, Jun-ichi

“…Tetrahydroisoquinoline derivatives were discovered as novel N-type calcium channel blockers for the treatment of neuropathic pain. In hit-to-lead study, we…”
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Corrigendum to “Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels” [Bioorg. Med. Chem. 22 (2014) 6899–6907] by Ogiyama, Takashi, Inoue, Makoto, Honda, Shugo, Yamada, Hiroyoshi, Watanabe, Toshihiro, Gotoh, Takayasu, Kiso, Tetsuo, Koakutsu, Akiko, Kakimoto, Shuichiro, Shishikura, Jun-ichi

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Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2/3) receptor function and exerts an analgesic effect in pain models by Kakimoto, Shuichiro, Nagakura, Yukinori, Tamura, Seiji, Watabiki, Tomonari, Shibasaki, Kumiko, Tanaka, Shohei, Mori, Masamichi, Sasamata, Masao, Okada, Masamichi

“…The P2X(2/3) receptor has an important role in the nociceptive transmission. Minodronic acid is a third third-generation bisphosphonate and a potent inhibitor…”
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