Search Results - "Kakiki, M"

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform by Satoh, T, Sugiura, S, Shin, K, Onuki-Nagasaki, R, Ishida, S, Kikuchi, K, Kakiki, M, Kanamori, T

“…This paper reports a multi-throughput multi-organ-on-a-chip system formed on a pneumatic pressure-driven medium circulation platform with a microplate-sized…”
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Cardiovascular Assessment of ER-118585, a Selective Phosphodiesterase 5 Inhibitor by Mizuno, Hiroshi, Adachi, Hideyuki, Kimura, Junko, Sawa, Yoshio, Kakiki, Motoharu, Lansdell, Kate, Saito, Mamoru, Kerns, William David

“…The aim of this study was to assess the cardiovascular effects of a selective phosphodiesterase 5 inhibitor ER-118585,…”
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Pharmacokinetics, metabolism and pharmacodynamics of a benzimidazole angiotensin II type 1 receptor antagonist in the beagle dog and cynomologus monkey by KAKIKI, M, ISHIHARA, H

“…1. The pharmacokinetics and disposition of E4177, an angiotensin II (Ang II) type 1 receptor antagonist, were studied in the beagle dog and cynomologus monkey…”
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Localization and disposition of a non-peptide angiotensin II type 1 receptor antagonist, and its glucuronide metabolite, in rat by KAKIKI, M., TADANO, K.

“…1. The disposition of radioactivity of a non-peptide angiotensin II type 1 receptor antagonist (E4177) has been studied in groups of male rats after a single…”
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Species differences and mechanism of the epimerization of a new MAO-A inhibitor by NAITOH, T., KAWAGUCHI, S., KAKIKI, M., OHE, H., KAJIWARA, A., HORIE, T.

“…1. (5R)-3-[2-((1S)-3-cyano-1-hydroxypropyl)benzothiazol-6-yl]-5-methoxymethyl2-oxazolidinone (E2011) has two chiral centers in its structure. In vivo optical…”
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Identification of the metabolites of a new oxazolidinone MAO-A inhibitor in rat by NAITOH, T., KAKIKI, M., KOZAKI, T., MISHIMA, M., YUZURIHA, T., HORIE, T.

“…1. Six metabolites present in rat urine after the oral administration of E2011…”
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Absorption, distribution, metabolism and excretion of a new, 14C-labelled oxazolidinone MAO-A inhibitor in rat and dog by NAITOH, T., MISHIMA, M., KAWAGUCHI, S., MATSUI, K., ANDOH, T., KAGEI, K., KAKIKI, M., YUZURIHA, T., HORIE, T.

“…1. After oral administration of 14C-labelled (5R)-3-\[2-((1S)-3-cyano-1-hydroxypropyl)benzothiazol-6-yl]-5-methoxymethyl-2-oxazolidinone (E2011) at a dose of 1…”
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Effects of a phosphodiesterase 3 inhibitor, olprinone, on rhythmical change in tension of human gastroepiploic artery by Adachi, Hideyuki, Kakiki, Motoharu, Kishi, Yoshihiko

“…The gastroepiploic artery, used widely as a conduit in coronary artery bypass grafting, has high vasospasticity. The aims of this study were to examine the…”
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Stereoselective determination of a new antidepressant, E2011, and its diastereoisomer as a metabolite by high-performance liquid chromatography by Naitoh, T, Kakiki, M, Kawaguchi, S, Kagei, Y, Horie, T

“…A stereoselective HPLC method has been developed for the determination of E2011 (compound I) and one of its metabolites and diastereoisomers, ER-20593…”
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Immunohistochemical study of cytochrome P450 2C and 3A in human non-neoplastic and neoplastic tissues by YOKOSE, T, DOY, M, TANIGUCHI, T, SHIMADA, T, KAKIKI, M, HORIE, T, MATSUZAKI, Y, MUKAI, K

“…Organ and cellular distribution and expression constancy of microsomal cytochrome P450 (CYP) 2C and 3A in humans were studied with new polyclonal antibodies to…”
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Pharmacokinetics, metabolism and pharmacodynamic s of a benzimidazole angiotensin II type 1 receptor antagonist in the beagle dog and cynomologus monkey by KAKIKI, M., ISHIHARA, H.

“…1. The pharmacokinetic s and disposition of E4177, an angiotensin II (Ang II) type 1 receptor antagonist, were studied in the beagle dog and cynomologus monkey…”
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4-(3-Chloro-4-methoxybenzyl)aminophthalazines:  Synthesis and Inhibitory Activity toward Phosphodiesterase 5 by Watanabe, Nobuhisa, Adachi, Hideyuki, Takase, Yasutaka, Ozaki, Hirofumi, Matsukura, Masayuki, Miyazaki, Kazuki, Ishibashi, Keiji, Ishihara, Hiroki, Kodama, Kohtarou, Nishino, Mayu, Kakiki, Motoharu, Kabasawa, Yasuhiro

“…We synthesized various 4-(3-chloro-4-methoxybenzyl)aminophthalazines substituted at the 1- and 6-positions and evaluated their inhibitory activity toward…”
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Expression of aldosterone synthase cytochrome P450 (P450aldo) mRNA in rat adrenal glomerulosa cells by angiotensin II type 1 receptor by Kakiki, M, Morohashi, K, Nomura, M, Omura, T, Horie, T

“…Changes in the mRNA levels for aldosterone synthase cytochrome P450 (P450aldo or CYP11B2) in rat adrenal glands were studied in response to angiotensin II type…”
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Expression of aldosterone synthase cytochrome P450 (P450aldo) mRNA in rat adrenal glomerulosa cells by angiotensin ii type1 receptor by Kakiki, M., Morohashi, K., Nomura, M., Omura, T., Horie, T.

“…Changes in the mRNA levels for aldosterone synthase cytochrome P450 (P450aldo or CYP11B2) in rat adrenal glands were studied in response to angiotensin II type…”
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Regulation of Aldosterone Synthase Cytochrome P450 (CYP11B2) and 11β-Hydroxylase Cytochrome P450 (CYP11B1) Expression in Rat Adrenal Zona Glomerulosa Cells by Low Sodium Diet and Angiotensin II Receptor Antagonists by KAKIKI, Motoharu, MOROHASHI, Ken-ichirou, NOMURA, Masatoshi, OMURA, Tsuneo, HORIE, Toru

“…Changes in the mRNA levels for aldosterone synthase cytochrome P450 (CYP11B2 or P450aldo) and 11β hydroxylase cytochrome P450 (CYP11B1 or P45011β) in rat…”
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Expression of Cytochrome P450 3A4 in Foveolar Epithelium with Intestinal Metaplasia of the Human Stomach by Yokose, Tomoyuki, Doy, Mikio, Kakiki, Motoharu, Horie, Tohru, Matsuzaki, Yasushi, Mukai, Kiyoshi

“…The expression of cytochrome P450 3A4 (CYP3A4) in the foveolar epithelium of the human stomach with intestinal metaplasia was studied using…”
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Localization of a Novel Non-peptide Angiotensin II Type 1 Receptor Antagonist, E4177, in Rat Adrenal Glomerulosa by KAKIKI, Motoharu, HORIE, Toru

“…We investigated the distribution of a novel angiotensin II type 1 (AT1) receptor antagonist, E4177 (4'-[2-cyclopropyl-7-methyl-3H-imidazo[5,…”
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Absorption, distribution, metabolism and excretion of a new, super(14)C-labelled oxazolidinone MAO-A inhibitor in rat and dog by Naitoh, T, Mishima, M, Kawaguchi, S, Matsui, K, Andoh, T, Kagei, K, Kakiki, M, Yuzuriha, T, Horie, T

“…After oral administration of super(14)C-labelled (5R)-3-[2-((1S)-3-cyano-1-hydroxypropyl)benzothiazol-6-yl]-5-metho x ymethyl-2-oxazolidinone (E2011) at a dose…”
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Absorption, distribution, metabolism and excretion of a new, 14 C-labelled oxazolidinone MAO-A inhibitor in rat and dog by NAITOH, T., MISHIMA, M., KAWAGUCHI, S., MATSUI, K., ANDOH, T., KAGEI, K., KAKIKI, M., YUZURIHA, T., HORIE, T.

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Some properties of tissue-type plasminogen activator reconstituted onto phospholipid and/or glycolipid vesicles by Soeda, S, Kakiki, M, Shimeno, H, Nagamatsu, A

“…Porcine heart tissue-type plasminogen activator (t-PA) was reconstituted onto large multilamellar liposomes with various lipid compositions and the kinetics of…”
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