Search Results - "Kakarla, Sunil"

Aging-associated dysfunction of Akt/protein kinase B: S-nitrosylation and acetaminophen intervention by Wu, Miaozong, Katta, Anjaiah, Gadde, Murali K, Liu, Hua, Kakarla, Sunil K, Fannin, Jacqueline, Paturi, Satyanarayana, Arvapalli, Ravi K, Rice, Kevin M, Wang, Yeling, Blough, Eric R

“…Aged skeletal muscle is characterized by an increased incidence of metabolic and functional disorders, which if allowed to proceed unchecked can lead to…”
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Iron-induced cardiac damage: role of apoptosis and deferasirox intervention by Wang, Yeling, Wu, Miaozong, Al-Rousan, Rabaa, Liu, Hua, Fannin, Jacqueline, Paturi, Satyanarayana, Arvapalli, Ravi Kumar, Katta, Anjaiah, Kakarla, Sunil K, Rice, Kevin M, Triest, William E, Blough, Eric R

“…Excess cardiac iron levels are associated with cardiac damage and can result in increased morbidity and mortality. Here, we hypothesize that elevations in…”
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A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats by Nasu-Kawaharada, Ritsuko, Ph.D, Nakamura, Akio, Ph.D, Kakarla, Sunil K., Ph.D, Blough, Eric R., Ph.D, Kohama, Kazuhiro, M.D., Ph.D, Kohama, Tomoko, M.D., Ph.D

“…Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart…”
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Effects of aging and gender on muscle mass and regulation of Akt-mTOR-p70s6k related signaling in the F344BN rat model by Paturi, Satyanarayana, Gutta, Anil K., Katta, Anjaiah, Kakarla, Sunil K., Arvapalli, Ravi K., Gadde, Murali K., Nalabotu, Siva K., Rice, Kevin M., Wu, Miaozong, Blough, Eric

“…Sarcopenia is the loss of muscle mass and strength which occurs with aging. Whether the molecular basis of sarcopenia differs with muscle type and across sex…”
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Impaired overload-induced hypertrophy in obese Zucker rat slow-twitch skeletal muscle by Paturi, Satyanarayana, Gutta, Anil K, Kakarla, Sunil K, Katta, Anjaiah, Arnold, Eric C, Wu, Miaozong, Rice, Kevin M, Blough, Eric R

“…1 Department of Biological Sciences, ; 2 Cell Differentiation and Development Center, ; 3 Department of Pharmacology, Physiology and Toxicology, Joan C…”
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Impaired overload-induced hypertrophy is associated with diminished mTOR signaling in insulin-resistant skeletal muscle of the obese Zucker rat by Katta, Anjaiah, Kundla, Sudarsanam, Kakarla, Sunil K, Wu, Miaozong, Fannin, Jacqueline, Paturi, Satyanarayana, Liu, Hua, Addagarla, Hari S, Blough, Eric R

“…Recent data have suggested that insulin resistance may be associated with a diminished ability of skeletal muscle to undergo hypertrophy (Paturi S, Gutta AK,…”
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Diminished muscle growth in the obese Zucker rat following overload is associated with hyperphosphorylation of AMPK and dsRNA-dependent protein kinase by Katta, Anjaiah, Kakarla, Sunil K, Manne, Nandini D P K, Wu, Miaozong, Kundla, Sudarsanam, Kolli, Madhukar B, Nalabotu, Siva K, Blough, Eric R

“…Previous data have suggested that insulin-resistant skeletal muscle may exhibit a diminished ability to undergo hypertrophy and that this result may be…”
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Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat by Kakarla, Sunil K., Fannin, Jacqueline C., Keshavarzian, Saba, Katta, Anjaiah, Paturi, Satyanarayana, Nalabotu, Siva K., Wu, Miaozong, Rice, Kevin M., Manzoor, Kamran, Walker, Ernest M., Blough, Eric R.

“…There is a growing need for pharmacological agents to manage cardiovascular disease in the rapidly growing elderly population. Here, we determine if…”
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Chronic paracetamol treatment influences indices of reactive oxygen species accumulation in the aging Fischer 344 X Brown Norway rat aorta by Rice, Kevin M, Meduru, Sarath, Kakarla, Sunil K, Katta, Anjaiah, Mupparaju, Sriram P, Kidd, Brent, Goebel, Lynne J, Blough, Eric R

“…Previous reports have demonstrated that increased levels of reactive oxygen species (ROS) and alterations in cell signaling characterize aging in the Fischer…”
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Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1/2 by Wu, Miaozong, Desai, Devashish H., Kakarla, Sunil K., Katta, Anjaiah, Paturi, Satyanarayana, Gutta, Anil K., Rice, Kevin M., Walker Jr, Ernest M., Blough, Eric R.

“…Background Aging‐related hyperglycemia is associated with increased oxidative stress and diminished muscle glucose transporter‐4 (Glut4) that may be regulated,…”
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Possible Molecular Mechanisms Underlying Age-Related Cardiomyocyte Apoptosis in the F344XBN Rat Heart by Kakarla, Sunil K., Rice, Kevin M., Katta, Anjaiah, Paturi, Satyanarayana, Wu, Miaozong, Kolli, Madhukar, Keshavarzian, Saba, Manzoor, Kamran, Wehner, Paulette S., Blough, Eric R.

“…Despite advances in treatment, age-related cardiac dysfunction still remains a leading cause of cardiovascular death. Recent data have suggested that increases…”
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Application of Poly(amidoamine) Dendrimers for Use in Bionanomotor Systems by Kolli, Madhukar B, Day, B. Scott, Takatsuki, Hideyo, Nalabotu, Siva K, Rice, Kevin M, Kohama, Kazuhiro, Gadde, Murali K, Kakarla, Sunil K, Katta, Anjaiah, Blough, Eric R

“…The study and utilization of bionanomotors represents a rapid and progressing field of nanobiotechnology. Here, we demonstrate that poly(amidoamine) (PAMAM)…”
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Deferasirox removes cardiac iron and attenuates oxidative stress in the iron‐overloaded gerbil by Al‐Rousan, Rabaa M., Paturi, Satyanarayana, Laurino, Joseph P., Kakarla, Sunil K., Gutta, Anil K., Walker, Ernest M., Blough, Eric R.

“…Iron‐induced cardiovascular disease is the leading cause of death in iron‐overloaded patients. Deferasirox is a novel, once daily oral iron chelator that was…”
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Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava by Rice, Kevin M, Desai, Devashish H, Kakarla, Sunil K, Katta, Anjaiah, Preston, Deborah L, Wehner, Paulette, Blough, Eric R

“…Diabetes mellitus is an important risk factor for increased vein graft failure after bypass surgery. However, the cellular and molecular mechanism(s)…”
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Deferasirox Decreases Age-Associated Iron Accumulation in the Aging F344XBN Rat Heart and Liver by Arvapalli, Ravi Kumar, Paturi, Satyanarayana, Laurino, Joseph P, Katta, Anjaiah, Kakarla, Sunil K, Gadde, Murali K, Wu, Miaozong, Rice, Kevin M, Walker, Ernest M, Wehner, Paulette, Blough, Eric R

“…It is thought that aging in rats and humans is associated with increases in iron accumulation and cell apoptosis. Here, we examine the relationship between…”
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Shear stress activates Akt during vascular smooth muscle cell reorientation by Rice, Kevin M., Kakarla, Sunil K., Mupparaju, Sriram P., Paturi, Satyanarayana, Katta, Anjaiah, Wu, Miaozong, Harris, Robert T., Blough, Eric R.

“…Vascular intervention procedures can lead to endothelial damage and expose the underlying VSMCs (vascular smooth muscle cells) to shear stress. Although shear…”
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Fluprostenol-induced MAPK signaling is independent of aging in Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta by Rice, Kevin M, Walker, Ernest M, Kakarla, Sunil K, Paturi, Satyanarayana, Wu, Miaozong, Narula, Sumit, Blough, Eric R

“…The factors that regulate vascular mechanotransduction and how this process may be altered with aging are poorly understood and have not been widely studied…”
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Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat by Rice, Kevin M., Blough, Eric R., Katta, Anjaiah, Kolli, Madhukar, Arvapalli, Ravikumar, Gadde, Murali K., Karkala, S. K., Wu, Miaozong, Paturi, Satyanarayana

“…Increased muscle loading results in the phosphorylation of the 70 kDa ribosomal S6 kinase (p70S6k), and this event is strongly correlated with the degree of…”
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Diminished muscle growth in the obese Zucker rat following overload is associated with hyperphosphorylation of AMPK and dsRNA-dependent protein kinase by KATTA, Anjaiah, KAKARLA, Sunil K, MANNE, Nandini D. P. K, MIAOZONG WU, KUNDLA, Sudarsanam, KOLLI, Madhukar B, NALABOTU, Siva K, BLOUGH, Eric R

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Lack Of Myosin Light Chain Isoform Expression In The Mechanical Overloaded Obese Zucker Rat Plantaris: 3000 Board #147 May 30 9:30 AM - 11:00 AM by Arnold, C. Eric, Evans, Gina Sobrero, Blough, Eric R., Kakarla, Sunil, Gutta, Aunil, Marley, William P., Reiser, Peter J.

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