Search Results - "Kakarla, Ramakrishna"

Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases by Kakarla, Ramakrishna, Karuturi, Praditha, Siakabinga, Queen, Kasi Viswanath, Matte, Dumala, Naresh, Guntupalli, Chakravarthi, Nalluri, Buchi N., Venkateswarlu, Kojja, Prasanna, Vani Sai, Gutti, Gopichand, Yadagiri, Ganesh, Gujjari, Lohitha

“…Neurological disorders incidences are increasing drastically due to complex pathophysiology, and the nonavailability of disease‐modifying agents. Several…”
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WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective by Ramakrishna, Kakarla, Nalla, Lakshmi Vineela, Naresh, Dumala, Venkateswarlu, Kojja, Viswanadh, Matte Kasi, Nalluri, Buchi N, Chakravarthy, Guntupalli, Duguluri, Sajusha, Singh, Payal, Rai, Sachchida Nand, Kumar, Ashish, Singh, Veer, Singh, Santosh Kumar

“…Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to…”
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Tangeretin confers neuroprotection, cognitive and memory enhancement in global cerebral ischemia in rats by Alla, Narayanarao, Palatheeya, Sujatha, Challa, Siva Reddy, Kakarla, Ramakrishna

“…Global cerebral ischemia is commonly associated with neurological deficits, including cognitive and memory impairments. The present study aims to investigate…”
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Vasicinone, a pyrroloquinazoline alkaloid from Adhatoda vasica Nees enhances memory and cognition by inhibiting cholinesterases in Alzheimer's disease by Bhanukiran, Kancharla, Singh, Ravi, T A, Gajendra, Ramakrishna, Kakarla, Singh, Sushil Kumar, Krishnamurthy, Sairam, Kumar, Ashok, Hemalatha, Siva

“…•Vasicinone (VAS) and vasicine (VA) were isolated from the DCM fraction of Adhatoda vasica.•VAS and VA interacted with at AChE and BuChE enzymes in-silico…”
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Indole-3 Carbinol and Diindolylmethane Mitigated β-Amyloid-Induced Neurotoxicity and Acetylcholinesterase Enzyme Activity: In Silico, In Vitro, and Network Pharmacology Study by Ramakrishna, Kakarla, Karuturi, Praditha, Siakabinga, Queen, T A, Gajendra, Krishnamurthy, Sairam, Singh, Shreya, Kumari, Sonia, Kumar, G Siva, Sobhia, M Elizabeth, Rai, Sachchida Nand

“…Alzheimer's disease (AD) is a neurodegenerative disease characterized by beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme…”
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Indole‐3‐carbinol ameliorated the neurodevelopmental deficits in neonatal anoxic injury in rats by Ramakrishna, Kakarla, Krishnamurthy, Sairam

“…Neonatal anoxia is linked to long‐lasting neurodevelopmental deficits. Due to the lack of pharmacological intervention to treat neonatal anoxia, there is…”
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Indole-3-carbinol ameliorated the isoproterenol-induced myocardial infarction via multimodal mechanisms in Wistar rats by Ramakrishna, Kakarla, Krishnamurthy, Sairam

“…The present study investigated the cardioprotection of Indole-3-carbinol on isoproterenol (ISO)-induced myocardial infarction in Wistar rats. I3C treatment…”
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Diindolylmethane ameliorates platelet aggregation and thrombosis: In silico, in vitro, and in vivo studies by Ramakrishna, Kakarla, Singh, Neha, Krishnamurthy, Sairam

“…Diindolylmethane (DIM), a major metabolite of indole-3-carbinol (I3C), plays a vital role in the pharmacological actions of I3C. The role of DIM in the…”
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Diet and Nutraceuticals for treatment and prevention of primary and secondary stroke: Emphasis on nutritional antiplatelet and antithrombotic agents by Kakarla, Ramakrishna, Vinjavarapu, Lakshmi Anusha, Krishnamurthy, Sairam

“…Ischemic stroke is a devastating disease that causes morbidity and mortality. Malnutrition following ischemic stroke is common in stroke patients. During the…”
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Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats by Alla, Narayanarao, Palatheeya, Sujatha, Challa, Siva Reddy, Kakarla, Ramakrishna

“…Global cerebral ischemia is one of the major causes of memory and cognitive impairment. Hyperactivation of acetylcholine esterase (AChE), oxidative stress, and…”
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Pharmacokinetic and Pharmacodynamic Properties of Indole-3-carbinol in Experimental Focal Ischemic Injury by Ramakrishna, Kakarla, Jain, Shreyans K., Krishnamurthy, Sairam

“…Background and Objectives Indole-3-carbinol (I3C) is reported to have neuroprotective properties in an animal model of ischemic stroke. However, the…”
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Indole-3-carbinol ameliorated the thioacetamide-induced hepatic encephalopathy in rats by Ramakrishna, Kakarla, Sinku, Sangeetha, Majumdar, Shreyasi, Singh, Neha, Gajendra, T.A., Rani, Asha, Krishnamurthy, Sairam

“…Indole-3-carbinol (I3C) is reported to have hepatic and neuroprotective properties. However, the I3C role in the protection of the liver and brain in the…”
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Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease by Gutti, Gopichand, Kakarla, Ramakrishna, Kumar, Devendra, Beohar, Mahima, Ganeshpurkar, Ankit, Kumar, Ashok, Krishnamurthy, Sairam, Singh, Sushil Kumar

“…Alzheimer's disease (AD) is associated with multifactorial neuropathological conditions, which include cholinergic deficit, amyloid-beta plaques formation,…”
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Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease by Gutti, Gopichand, Leifeld, Jennifer, Kakarla, Ramakrishna, Bajad, Nilesh Gajanan, Ganeshpurkar, Ankit, Kumar, Ashok, Krishnamurthy, Sairam, Klein-Schmidt, Christina, Tapken, Daniel, Hollmann, Michael, Singh, Sushil Kumar

“…Alzheimer's disease (AD) is a progressive brain disorder associated with slow loss of brain functions leading to memory failure and modest changes in behavior…”
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Antiplatelet and antithrombotic properties of methanolic leaf extract of plumbago zeylanica L.: GC-MS and HR-LCMS metabolite profiling by Guguloth, Sarvan Kumar, Malothu, Narender, Ganta, Narayana Murthy, Ramakrishna, Kakarla, Guntupalli, Chakravarthi

“…Cardiovascular illnesses like ischemic stroke, deep vein thrombosis, myocardial infarction, and cerebrovascular complications, which eventually cause morbidity…”
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Comparison of One-Year Post-Operative Evolution of Children Born of COVID-19-Positive Mothers vs. COVID-19-Negative Pregnancies Having Congenital Gastrointestinal Malformation and Having Received Proper Parenteral Nutrition during Their Hospital Stay by Brandibur, Timea Elisabeta, Kundnani, Nilima Rajpal, Ramakrishna, Kakarla, Mederle, Alexandra, Manea, Aniko Maria, Boia, Marioara, Popoiu, Marius Calin

“…The long-term effects on neonates born of COVID-19-positive pregnancies are still unclear. Congenital gastrointestinal malformations (CGIMs) often require…”
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WNT-[beta] Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective by Ramakrishna, Kakarla, Nalla, Lakshmi Vineela, Naresh, Dumala, Venkateswarlu, Kojja, Viswanadh, Matte Kasi, Nalluri, Buchi N, Chakravarthy, Guntupalli, Duguluri, Sajusha, Singh, Payal, Rai, Sachchida Nand, Kumar, Ashish, Singh, Veer, Singh, Santosh Kumar

“…Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to…”
Get full text

Indole-3-carbinol ameliorated the isoproterenol-induced myocardial infarction via multimodal mechanisms in Wistar rats by Ramakrishna, Kakarla, Krishnamurthy, Sairam

“…The present study investigated the cardioprotection of Indole-3-carbinol on isoproterenol (ISO)-induced myocardial infarction in Wistar rats. I3C treatment…”
Get full text