Search Results - "Kakar, Shefali M"

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches by Hosea, Natilie A., Collard, Wendy T., Cole, Susan, Maurer, Tristan S., Fang, Rick X., Jones, Hannah, Kakar, Shefali M., Nakai, Yasuhiro, Smith, Bill J., Webster, Rob, Beaumont, Kevin

“…Quantitative prediction of human pharmacokinetics is critical in assessing the viability of drug candidates and in determining first‐in‐human dosing. Numerous…”
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Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors by Arcari, Joel T., Beebe, Jean S., Berliner, Martin A., Bernardo, Vincent, Boehm, Merin, Borzillo, Gary V., Clark, Tracey, Cohen, Bruce D., Connell, Richard D., Frost, Heather N., Gordon, Deborah A., Hungerford, William M., Kakar, Shefali M., Kanter, Aaron, Keene, Nandell F., Knauth, Elizabeth A., LaGreca, Susan D., Lu, Yong, Martinez-Alsina, Louis, Marx, Matthew A., Morris, Joel, Patel, Nandini C., Savage, Doug, Soderstrom, Cathy I., Thompson, Carl, Tkalcevic, George, Tom, Norma J., Vajdos, Felix F., Valentine, James J., Vincent, Patrick W., Wessel, Matthew D., Chen, Jinshan M.

“…The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are…”
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6′7′-Dihydroxybergamottin Contributes to the Grapefruit Juice Effect by Kakar, Shefali M., Paine, Mary F., Stewart, Paul W., Watkins, Paul B.

“…Objective ur objective was to assess the contribution of 6′,7′‐dihydroxybergamottin (DHB) to the inhibitory effect of grapefruit juice toward intestinal…”
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6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect by Kakar, Shefali M, Paine, Mary F, Stewart, Paul W, Watkins, Paul B

“…Our objective was to assess the contribution of 6',7'-dihydroxybergamottin (DHB) to the inhibitory effect of grapefruit juice toward intestinal cytochrome P450…”
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6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect by KAKAR, Shefali M, PAINE, Mary F, STEWART, Paul W, WATKINS, Paul B

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