Search Results - "Kakajan Komurov"

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies by Smith, Molly A., Choudhary, Gaurav S., Pellagatti, Andrea, Choi, Kwangmin, Bolanos, Lyndsey C., Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Von Ahrens, Dagny, Pradhan, Kith, Steeples, Violetta, Kim, Sanghyun, Steidl, Ulrich, Walter, Matthew, Fraser, Iain D. C., Kulkarni, Aishwarya, Salomonis, Nathan, Komurov, Kakajan, Boultwood, Jacqueline, Verma, Amit, Starczynowski, Daniel T.

“…Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have…”
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NetWalker: a contextual network analysis tool for functional genomics by Komurov, Kakajan, Dursun, Serkan, Erdin, Serkan, Ram, Prahlad T

“…Functional analyses of genomic data within the context of a priori biomolecular networks can give valuable mechanistic insights. However, such analyses are not…”
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Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers by Navneet Singh, Lindsey Romick-Rosendale, Miki Watanabe-Chailland, Lisa M. Privette Vinnedge, Kakajan Komurov

“…Oncogenic kinase inhibitors show short-lived responses in the clinic due to high rate of acquired resistance. We previously showed that pharmacologically…”
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Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes by Taube, Joseph H., Herschkowitz, Jason I., Komurov, Kakajan, Zhou, Alicia Y., Gupta, Supriya, Yang, Jing, Hartwell, Kimberly, Onder, Tamer T., Gupta, Piyush B., Evans, Kurt W., Hollier, Brett G., Ram, Prahlad T., Lander, Eric S., Rosen, Jeffrey M., Weinberg, Robert A., Mani, Sendurai A.

“…The epithelial-to-mesenchymal transition (EMT) produces cancer cells that are invasive, migratory, and exhibit stem cell characteristics, hallmarks of cells…”
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Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia by Kesarwani, Meenu, Kincaid, Zachary, Gomaa, Ahmed, Huber, Erika, Rohrabaugh, Sara, Siddiqui, Zain, Bouso, Muhammad F, Latif, Tahir, Xu, Ming, Komurov, Kakajan, Mulloy, James C, Cancelas, Jose A, Grimes, H Leighton, Azam, Mohammad

“…The intrinsic resistance of BCR-ABL-expressing chronic myeloid leukemia stem cells to treatment with tyrosine-kinase inhibitors requires growth-factor…”
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Revealing static and dynamic modular architecture of the eukaryotic protein interaction network by Komurov, Kakajan, White, Michael

“…In an effort to understand the dynamic organization of the protein interaction network and its role in the regulation of cell behavior, positioning of proteins…”
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Drug resistance mechanisms create targetable proteostatic vulnerabilities in Her2+ breast cancers by Singh, Navneet, Romick-Rosendale, Lindsey, Watanabe-Chailland, Miki, Privette Vinnedge, Lisa M, Komurov, Kakajan

“…Oncogenic kinase inhibitors show short-lived responses in the clinic due to high rate of acquired resistance. We previously showed that pharmacologically…”
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A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes by Fang, Jing, Liu, Xiaona, Bolanos, Lyndsey, Barker, Brenden, Rigolino, Carmela, Cortelezzi, Agostino, Oliva, Esther N, Cuzzola, Maria, Grimes, H Leighton, Fontanillo, Celia, Komurov, Kakajan, MacBeth, Kyle, Starczynowski, Daniel T

“…Lenalidomide, which is used to treat myelodysplastic syndrome, kills mutation-bearing hematopoietic cells by increasing expression of the G-protein-coupled…”
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Basal and Treatment-Induced Activation of AKT Mediates Resistance to Cell Death by AZD6244 (ARRY-142886) in Braf-Mutant Human Cutaneous Melanoma Cells by VASHISHT GOPAL, Y. N, WANLENG DENG, WOODMAN, Scott E, KOMUROV, Kakajan, RAM, Prahlad, SMITH, Paul D, DAVIES, Michael A

“…The majority of melanomas show constitutive activation of the RAS-RAF-MAP/ERK kinase (MEK)-mitogen-activated protein kinase (MAPK) pathway. AZD6244 is a…”
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Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion by Tripathi, Reshmi, Modur, Vishnu, Senovilla, Laura, Kroemer, Guido, Komurov, Kakajan

“…Anti-tumor immune responses impede tumor formation, and cancers have evolved many mechanisms of immune evasion. Confirming earlier findings, we show that human…”
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Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects by Modur, Vishnu, Muhammad, Belal, Yang, Jun-Qi, Zheng, Yi, Komurov, Kakajan, Guo, Fukun

“…The clinical response to immune checkpoint blockade (ICB) correlates with tumor-infiltrating cytolytic T lymphocytes (CTLs) prior to treatment. However, many…”
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Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer by Kim, Hyun Seok, Mendiratta, Saurabh, Kim, Jiyeon, Pecot, Chad Victor, Larsen, Jill E., Zubovych, Iryna, Seo, Bo Yeun, Kim, Jimi, Eskiocak, Banu, Chung, Hannah, McMillan, Elizabeth, Wu, Sherry, De Brabander, Jef, Komurov, Kakajan, Toombs, Jason E., Wei, Shuguang, Peyton, Michael, Williams, Noelle, Gazdar, Adi F., Posner, Bruce A., Brekken, Rolf A., Sood, Anil K., Deberardinis, Ralph J., Roth, Michael G., Minna, John D., White, Michael A.

“…Context-specific molecular vulnerabilities that arise during tumor evolution represent an attractive intervention target class. However, the frequency and…”
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Use of data-biased random walks on graphs for the retrieval of context-specific networks from genomic data by Komurov, Kakajan, White, Michael A, Ram, Prahlad T

“…Extracting network-based functional relationships within genomic datasets is an important challenge in the computational analysis of large-scale data. Although…”
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Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation by Brown, Nicholas E., Paluch, Andrew M., Nashu, Madison A., Komurov, Kakajan, Waltz, Susan E.

“…Current treatment strategies provide minimal results for patients with castration-resistant prostate cancer (CRPC). Attempts to target the androgen receptor…”
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The glucose‐deprivation network counteracts lapatinib‐induced toxicity in resistant ErbB2‐positive breast cancer cells by Komurov, Kakajan, Tseng, Jen‐Te, Muller, Melissa, Seviour, Elena G, Moss, Tyler J, Yang, Lifeng, Nagrath, Deepak, Ram, Prahlad T

“…Dynamic interactions between intracellular networks regulate cellular homeostasis and responses to perturbations. Targeted therapy is aimed at perturbing…”
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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma by Eskiocak, Banu, McMillan, Elizabeth A, Mendiratta, Saurabh, Kollipara, Rahul K, Zhang, Hailei, Humphries, Caroline G, Wang, Changguang, Garcia-Rodriguez, Jose, Ding, Ming, Zaman, Aubhishek, Rosales, Tracy I, Eskiocak, Ugur, Smith, Michael P, Sudderth, Jessica, Komurov, Kakajan, Deberardinis, Ralph J, Wellbrock, Claudia, Davies, Michael A, Wargo, Jennifer A, Yu, Yonghao, De Brabander, Jef K, Williams, Noelle S, Chin, Lynda, Rizos, Helen, Long, Georgina V, Kittler, Ralf, White, Michael A

“…Genomic diversity among melanoma tumors limits durable control with conventional and targeted therapies. Nevertheless, pathologic activation of the ERK1/2…”
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Defective transcription elongation in a subset of cancers confers immunotherapy resistance by Modur, Vishnu, Singh, Navneet, Mohanty, Vakul, Chung, Eunah, Muhammad, Belal, Choi, Kwangmin, Chen, Xiaoting, Chetal, Kashish, Ratner, Nancy, Salomonis, Nathan, Weirauch, Matthew T., Waltz, Susan, Huang, Gang, Privette-Vinnedge, Lisa, Park, Joo-Seop, Janssen, Edith M., Komurov, Kakajan

“…The nature and role of global transcriptional deregulations in cancers are not fully understood. We report that a large proportion of cancers have widespread…”
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Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence by Matrka, Marie C, Cimperman, Katherine A, Haas, Sarah R, Guasch, Geraldine, Ehrman, Lisa A, Waclaw, Ronald R, Komurov, Kakajan, Lane, Adam, Wikenheiser-Brokamp, Kathryn A, Wells, Susanne I

“…Esophageal cancer occurs as either squamous cell carcinoma (ESCC) or adenocarcinoma. ESCCs comprise almost 90% of cases worldwide, and recur with a less than…”
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Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer by Oatman, Nicole, Dasgupta, Nupur, Arora, Priyanka, Choi, Kwangmin, Gawali, Mruniya V, Gupta, Nishtha, Parameswaran, Sreeja, Salomone, Joseph, Reisz, Julie A, Lawler, Sean, Furnari, Frank, Brennan, Cameron, Wu, Jianqiang, Sallans, Larry, Gudelsky, Gary, Desai, Pankaj, Gebelein, Brian, Weirauch, Matthew T, D'Alessandro, Angelo, Komurov, Kakajan, Dasgupta, Biplab

“…The lipogenic enzyme stearoyl CoA desaturase (SCD) plays a key role in tumor lipid metabolism and membrane architecture. SCD is often up-regulated and a…”
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mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment by Orr-Asman, Melissa A, Chu, Zhengtao, Jiang, Min, Worley, Mariah, LaSance, Kathleen, Koch, Sheryl E, Carreira, Vinicius S, Dahche, Hanan M, Plas, David R, Komurov, Kakajan, Qi, Xiaoyang, Mercer, Carol A, Anthony, Lowell B, Rubinstein, Jack, Thomas, Hala E

“…Inhibition of mTOR signaling using the rapalog everolimus is an FDA-approved targeted therapy for patients with lung and gastroenteropancreatic neuroendocrine…”
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