Search Results - "Kajiwara, Chiaki"

Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species by Kajiwara, Chiaki, Kusaka, Yu, Kimura, Soichiro, Yamaguchi, Tetsuo, Nanjo, Yuta, Ishii, Yoshikazu, Udono, Heiichiro, Standiford, Theodore J, Tateda, Kazuhiro

“…In infection, macrophages play a critical role in the host defense response. Metformin, an oral drug for type 2 diabetes, is attracting attention as a new…”
Get full text

Apoptosis Inhibitor of Macrophages Contributes to the Chronicity of Mycobacterium avium Infection by Promoting Foamy Macrophage Formation by Kajiwara, Chiaki, Shiozawa, Ayako, Urabe, Naohisa, Yamaguchi, Tetsuo, Kimura, Soichiro, Akasaka, Yoshikiyo, Ishii, Yoshikazu, Tateda, Kazuhiro

“…In Mycobacterium avium infections, macrophages play a critical role in the host defense response. Apoptosis inhibitor of macrophage (AIM), also known as CD5L,…”
Get full text

Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells by Imai, Takashi, Kato, Yu, Kajiwara, Chiaki, Mizukami, Shusaku, Ishige, Ikuo, Ichiyanagi, Tomoko, Hikida, Masaki, Wang, Ji-Yang, Udono, Heiichiro

“…In antigen (Ag) cross-presentation, dendritic cells (DCs) take up extracellular Ag and translocate them from the endosome to the cytosol for proteasomal…”
Get full text

Role of interleukin-17 in a murine community-associated methicillin-resistant Staphylococcus aureus pneumonia model by Shibue, Yasushi, Kimura, Soichiro, Kajiwara, Chiaki, Iwakura, Yoichiro, Yamaguchi, Keizo, Tateda, Kazuhiro

“…Interleukin (IL)-17 is a key member of the Th17 cytokines and has been reported to be involved in the pathomechanisms underlying various diseases, including…”
Get full text

Traditional Japanese Herbal Medicine Hochu-Ekki-to Promotes Pneumococcal Colonization Clearance via Macrophage Activation and Interleukin 17A Production in Mice by Nakakubo, Sho, Kimura, Soichiro, Mimura, Kazuyuki, Kajiwara, Chiaki, Ishii, Yoshikazu, Konno, Satoshi, Tateda, Kazuhiro

“…may colonize the nasopharynx, and as pneumococcal colonization causes invasive diseases and the subsequent transmission, reducing bacterial burden in the nasal…”
Get full text

Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation by Ichiyanagi, Tomoko, Imai, Takashi, Kajiwara, Chiaki, Mizukami, Shusaku, Nakai, Akira, Nakayama, Toshinori, Udono, Heiichiro

“…Extracellular HSP90 associated with Ag peptides have been demonstrated to efficiently cross-prime T cells, following internalization by dendritic cells (DCs)…”
Get full text

Increased Incidence and Plasma-Biofilm Formation Ability of SCCmec Type IV Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated From Patients With Bacteremia by Hamada, Masakaze, Yamaguchi, Tetsuo, Sato, Ayami, Ono, Daisuke, Aoki, Kotaro, Kajiwara, Chiaki, Kimura, Soichiro, Maeda, Tadashi, Sasaki, Masakazu, Murakami, Hinako, Ishii, Yoshikazu, Tateda, Kazuhiro

“…In Japan, Staphylococcal cassette chromosome mec (SCC mec ) type IV methicillin-resistant Staphylococcus aureus (MRSA) is an increasingly prominent cause of…”
Get full text

Analysis of synergy between beta-lactams and anti-methicillin-resistant Staphylococcus aureus agents from the standpoint of strain characteristics and binding action by Ono, Daisuke, Yamaguchi, Tetsuo, Hamada, Masakaze, Sonoda, Shiro, Sato, Ayami, Aoki, Kotaro, Kajiwara, Chiaki, Kimura, Soichiro, Fujisaki, Momoko, Tojo, Hiroyuki, Sasaki, Masakazu, Murakami, Hinako, Kato, Keisuke, Ishii, Yoshikazu, Tateda, Kazuhiro

“…In light of the increasing number of clinical cases resistant to traditional monotherapies and the lack of novel antimicrobial agents, combination therapy is…”
Get full text

Differential MyD88/IRAK4 requirements for cross‐priming and tumor rejection induced by heat shock protein 70‐model antigen fusion protein by Mizukami, Shusaku, Kajiwara, Chiaki, Tanaka, Masato, Kaisho, Tsuneyasu, Udono, Heiichiro

“…Priming of CD8+ T cells requires two signals, one produced by T‐cell receptor recognition of antigen, and a second that is often provided by the innate immune…”
Get full text

Both CD4+ and CD8+ T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors by Mizukami, Shusaku, Kajiwara, Chiaki, Ishikawa, Hiroshi, Katayama, Ichiro, Yui, Katsuyuki, Udono, Heiichiro

“…Vaccination with heat shock proteins (HSP) protects mice from challenge with the tumor from which the HSP were isolated. The antigenicity of HSP vaccination is…”
Get full text

Evidence of latent molecular diversity determining the virulence of community‐associated MRSA USA300 clones in mice by Sonoda, Shiro, Yamaguchi, Tetsuo, Aoki, Kotaro, Ono, Daisuke, Sato, Ayami, Kajiwara, Chiaki, Kimura, Soichiro, Akasaka, Yoshikiyo, Ishii, Yoshikazu, Miyazaki, Yasunari, Inase, Naohiko, Tateda, Kazuhiro

“…Introduction The USA300 clone of community‐associated MRSA is reported to be hypervirulent and epidemic in the United States. This clone causes a variety of…”
Get full text

HSP90α deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation by Li, Yingqian, Li, Shuyin, Hoshino, Mari, Ishikawa, Rikiya, Kajiwara, Chiaki, Gao, Xiang, Zhao, Yaofeng, Ishido, Satoshi, Udono, Heiichiro, Wang, Ji-Yang

“…Heat shock protein 90 (HSP90) is a molecular chaperone required for efficient antigen presentation and cross-presentation. In addition, HSP90 was recently…”
Get full text

Spermatogenesis arrest caused by conditional deletion of Hsp90α in adult mice by Kajiwara, Chiaki, Kondo, Shiho, Uda, Shizuha, Dai, Lei, Ichiyanagi, Tomoko, Chiba, Tomoki, Ishido, Satoshi, Koji, Takehiko, Udono, Heiichiro

“…It is controversial whether a functional androgen receptor (AR) on germ cells, including spermatogonia, is essential for their development into sperm and,…”
Get full text

HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation by Kato, Yu, Kajiwara, Chiaki, Ishige, Ikuo, Mizukami, Shusaku, Yamazaki, Chihiro, Eikawa, Shingo, Kakimi, Kazuhiro, Udono, Heiichiro

“…Antigens (Ag) from cancer or virus-infected cells must be internalized by dendritic cells (DCs) to be presented to CD8+ T cells, which eventually differentiate…”
Get full text

Corrigendum to “N-acetyl-cysteine mediates protection against Mycobacterium avium through induction of human β-defensin-2” [Microb Infect 22 (10) (2020) 567–575] by Shiozawa, Ayako, Kajiwara, Chiaki, Ishii, Yoshikazu, Tateda, Kazuhiro

Get full text

N-acetyl-cysteine mediates protection against Mycobacterium avium through induction of human β-defensin-2 in a mouse lung infection model by Shiozawa, Ayako, Kajiwara, Chiaki, Ishii, Yoshikazu, Tateda, Kazuhiro

“…Mycobacterium avium complex is a causative organism for refractory diseases. In this study, we examined the effects of N-acetyl-cysteine on M. avium infection…”
Get full text

Corrigendum to "N-acetyl-cysteine mediates protection against Mycobacterium avium through induction of human β-defensin-2" Microb Infect 22 (10) (2020) 567-575 by Shiozawa, Ayako, Kajiwara, Chiaki, Ishii, Yoshikazu, Tateda, Kazuhiro

Get full text

Intrinsic clarithromycin heteroresistance in Mycobacterium avium by Ito, Ai, Nanjo, Yuta, Kajiwara, Chiaki, Shiozawa, Ayako, Urabe, Naohisa, Homma, Sakae, Kishi, Kazuma, Yamada, Kageto, Ishii, Yoshikazu, Tateda, Kazuhiro

“…Mycobacterium avium is associated with pulmonary disease in otherwise healthy adults. Several clarithromycin-refractory cases have been reported, including…”
Get full text

Extracellular and Non-Chaperone Function of Heat Shock Protein−90α Is Required for Skin Wound Healing by Bhatia, Ayesha, O’Brien, Kathryn, Guo, Jiacong, Lincoln, Vadim, Kajiwara, Chiaki, Chen, Mei, Woodley, David T., Udono, Heiichiro, Li, Wei

“…Despite years of effort and investment, there are few topical or systemic medications for skin wounds. Identifying natural drivers of wound healing could…”
Get full text

Efficacy of β-Lactam-plus-Macrolide Combination Therapy in a Mouse Model of Lethal Pneumococcal Pneumonia by Yoshioka, Daisuke, Kajiwara, Chiaki, Ishii, Yoshikazu, Umeki, Kenji, Hiramatsu, Kazufumi, Kadota, Jun-Ichi, Tateda, Kazuhiro

“…Community-acquired pneumonia is a common disease with considerable morbidity and mortality, for which Streptococcus pneumoniae is accepted as a leading cause…”
Get full text