Search Results - "Kajigaya, S."

Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia by Aalbers, A M, Calado, R T, Young, N S, Zwaan, C M, Wu, C, Kajigaya, S, Coenen, E A, Baruchel, A, Geleijns, K, de Haas, V, Kaspers, G J L, Kuijpers, T W, Reinhardt, D, Trka, J, Zimmermann, M, Pieters, R, van der Velden, V H J, van den Heuvel-Eibrink, M M

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Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations by Calado, R. T., Regal, J. A., Kajigaya, S., Young, N. S.

“…Background  Loss‐of‐function mutations in telomerase complex genes reduce telomerase activity and shorten overall telomere length in leucocytes, and they can…”
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RMRP mutations in hematological disorders by Graf, SA, Calado, RT, Kajigaya, S, Young, NS

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Molecular Cloning of a Docking Protein, BRDG1, That Acts Downstream of the Tec Tyrosine Kinase by Ohya, Ken-ichi, Kajigaya, Sachiko, Kitanaka, Akira, Yoshida, Koji, Miyazato, Akira, Yamashita, Yoshihiro, Yamanaka, Takeo, Ikeda, Uichi, Shimada, Kazuyuki, Ozawa, Keiya, Mano, Hiroyuki

“…Tec, Btk, Itk, Bmx, and Txk constitute the Tec family of protein tyrosine kinases (PTKs), a family with the distinct feature of containing a pleckstrin…”
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Neutralizing linear epitopes of B19 parvovirus cluster in the VP1 unique and VP1-VP2 junction regions by SAIKAWA, T, ANDERSON, S, MOMOEDA, M, KAJIGAYA, S, YOUNG, N. S

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Cryo-electron microscopy studies of empty capsids of human parvovirus B19 complexed with its cellular receptor by Chipman, P R, Agbandje-McKenna, M, Kajigaya, S, Brown, K E, Young, N S, Baker, T S, Rossmann, M G

“…The three-dimensional structures of human parvovirus B19 VP2 capsids, alone and complexed with its cellular receptor, globoside, have been determined to 26…”
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The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transfected cells by OZAWA, K, AYUB, J, KAJIGAYA, S, SHIMADA, T, YOUNG, N

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Self-Assembled B19 Parvovirus Capsids, Produced in a Baculovirus System, are Antigenically and Immunogenically Similar to Native Virions by Kajigaya, Sachiko, Fujii, Hiroyuki, Field, Anne, Anderson, Stacie, Rosenfeld, Stephen, Anderson, Larry J., Shimada, Takashi, Young, Neal S.

“…B19 parvovirus is pathogenic in humans, causing fifth disease, transient aplastic crisis, some cases of hydrops fetalis, and acquired pure red cell aplasia…”
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A putative nucleoside triphosphate-binding domain in the nonstructural protein of B19 parvovirus is required for cytotoxicity by Momoeda, M, Wong, S, Kawase, M, Young, N S, Kajigaya, S

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Candidate Recombinant Vaccine for Human B19 Parvovirus by Bansal, Geetha P., Hatfield, Jacqueline A., Dunn, Frances E., Kramer, Andrew A., Brady, Francine, Riggin, Charles H., Collett, Marc S., Yoshimoto, Kohji, Kajigaya, Sachiko, Young, Neal S.

“…Recombinant baculoviruses were used to produce human B19 parvovirus empty capsids composed of only VP2 and VP2 capsids containing 4%,25%,35%, or 41% VP1…”
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Unique region of the minor capsid protein of human parvovirus B19 is exposed on the virion surface by Rosenfeld, S J, Yoshimoto, K, Kajigaya, S, Anderson, S, Young, N S, Field, A, Warrener, P, Bansal, G, Collett, M S

“…Capsids of the B19 parvovirus are composed of major (VP2; 58 kD) and minor (VP1; 83 kD) structural proteins. These proteins are identical except for a unique…”
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Mutations in TERT, the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia by Yamaguchi, Hiroki, Calado, Rodrigo T, Ly, Hinh, Kajigaya, Sachiko, Baerlocher, Gabriela M, Chanock, Stephen J, Lansdorp, Peter M, Young, Neal S

“…The finding of shortened telomeres in leukocytes from patients with aplastic anemia prompted a search for mutations in genes that maintain the structure of the…”
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First Continuous Propagation of B19 Parvovirus in a Cell Line by Shimomura, Satoshi, Komatsu, Norio, Frickhofen, Norbert, Anderson, Stacie, Kajigaya, Sachiko, Young, Neal S.

“…The pathogenic human parvovirus B19 has extreme tropism for human erythroid progenitor cells and has resisted cultivation in conventional cell lines. We report…”
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Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemia by Dumitriu, Bogdan, Feng, Xingmin, Townsley, Danielle M., Ueda, Yasutaka, Yoshizato, Tetsuichi, Calado, Rodrigo T., Yang, Yanqin, Wakabayashi, Yoshiyuki, Kajigaya, Sachiko, Ogawa, Seishi, Zhu, Jun, Young, Neal S.

“…The pathophysiology of severe aplastic anemia (SAA) is immune-mediated destruction of hematopoietic stem and progenitor cells (HSPCs). Most patients respond to…”
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A Genetically Engineered Cell Line that Produces Empty Capsids of B19 (Human) Parvovirus by Kajigaya, Sachiko, Shimada, Takashi, Fujita, Shinsuke, Young, Neal S.

“…B19 parvovirus is pathogenic in humans, causing the common childhood exanthem fifth disease and bone-marrow failure, both acute (transient aplastic crisis of…”
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Parvovirus Particles as Platforms for Protein Presentation by Miyamura, Koichi, Kajigaya, Sachiko, Momoeda, Mikio, Smith-Gill, Sandra J., Young, Neal S.

“…Empty capsids of the human pathogenic parvovirus B19 can be produced in a baculovirus system. B19 capsids are composed mainly of major capsid protein (VP2) and…”
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The transcriptional regulator YY1 binds to the 5'-terminal region of B19 parvovirus and regulates P6 promoter activity by Momoeda, M, Kawase, M, Jane, S M, Miyamura, K, Young, N S, Kajigaya, S

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The Fanconi Anemia Complementation Group C Gene (FAC) Suppresses Transformation of Mutant Fibroblasts by the SV40 Virus by Liu, J.M., Poiley, J., Devetten, M., Kajigaya, S., Walsh, C.E.

“…Fanconi anemia (FA) is a heterogeneous genetic syndrome manifested by bone marrow failure and consisting of at least five complementation groups (A, B, C, D,…”
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Modest truncation of the major capsid protein abrogates B19 parvovirus capsid formation by Kawase, M, Momoeda, M, Young, N S, Kajigaya, S

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Identification of novel microRNA signatures linked to acquired aplastic anemia by Hosokawa, Kohei, Muranski, Pawel, Feng, Xingmin, Keyvanfar, Keyvan, Townsley, Danielle M, Dumitriu, Bogdan, Chen, Jichun, Kajigaya, Sachiko, Taylor, James G, Hourigan, Christopher S, Barrett, A John, Young, Neal S

“…Emerging evidence indicates that microRNA control and modulate immunity. MicroRNA have not been investigated in acquired aplastic anemia, a T-cell-mediated…”
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