Search Results - "Kaji, Mark D"

Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2 by Kaji, Mark D., Noonan, Jennifer D., Geary, Timothy G., Beech, Robin N.

“…Nematode glutamate-gated chloride channels (GluCls) are targets of ivermectin (IVM) and moxidectin (MOX), structurally dissimilar macrocyclic lactone (ML)…”
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A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors From Necator americanus and Ancylostoma ceylanicum by Kaji, Mark D, Geary, Timothy G, Beech, Robin N

“…Effective control of hookworm infections in humans and animals relies on using a small group of anthelmintics. Many of these drugs target cholinergic…”
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A molecular characterization of the agonist binding site of a nematode cys‐loop GABA receptor by Kaji, Mark D, Kwaka, Ariel, Callanan, Micah K, Nusrat, Humza, Desaulniers, Jean‐Paul, Forrester, Sean G

“…Background and Purpose Cys‐loop GABA receptors represent important targets for human chemotherapeutics and insecticides and are potential targets for novel…”
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Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: Modulation by macrocyclic lactone anthelmintics and a receptor for piperazine by Brown, David D.R., Siddiqui, Salma Z., Kaji, Mark D., Forrester, Sean G.

“…Invertebrate ligand-gated chloride channels are well recognized as important targets for several insecticides and anthlemintics. Hco-UNC-49 is a GABA-gated…”
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A Molecular Characterization of Agonists That Bind to Hco-UNC-49, a GABA-gated Chloride Channel From Haemonchus contortus by Kaji, Mark D

“…Haemonchus contortus is a blood feeding parasitic nematode infecting ruminants causing anemia and poor health at great economic cost. The ability to…”
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