Search Results - "Kaja, Amala"
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Fine-Tuning of FACT by the Ubiquitin Proteasome System in Regulation of Transcriptional Elongation
Published in Molecular and cellular biology (01-06-2016)“…FACT ( fa cilitates c hromatin t ranscription), an evolutionarily conserved histone chaperone involved in transcription and other DNA transactions, is…”
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Chromatin and non-chromatin immunoprecipitations to capture protein–protein and protein-nucleic acid interactions in living cells
Published in Methods (San Diego, Calif.) (01-10-2023)“…•Analysis of the protein-nucleic acid interactions in vivo.•Analysis of the protein–protein interactions in vivo. Analysis of the protein-RNA interactions in…”
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A novel ubiquitin–proteasome system regulation of Sgf73/ataxin-7 that maintains the integrity of the coactivator SAGA in orchestrating transcription
Published in Genetics (Austin) (06-07-2023)“…Abstract Ataxin-7 maintains the integrity of Spt-Ada-Gcn5-Acetyltransferase (SAGA), an evolutionarily conserved coactivator in stimulating preinitiation…”
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TOR Facilitates the Targeting of the 19S Proteasome Subcomplex To Enhance Transcription Complex Assembly at the Promoters of the Ribosomal Protein Genes
Published in Molecular and cellular biology (01-07-2018)“…TOR (target of rapamycin) has been previously implicated in transcriptional stimulation of the ribosomal protein (RP) genes via enhanced recruitment of NuA4…”
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Ubiquitin-proteasome system regulation of a key gene regulatory factor, Paf1C
Published in Gene (05-02-2024)“…Paf1 (Polymerase-associated factor 1) complex (Paf1C) is evolutionarily conserved from yeast to humans, and facilitates transcription elongation as well as…”
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Tandem Affinity Purification and Mass-Spectrometric Analysis of FACT and Associated Proteins
Published in Methods in molecular biology (Clifton, N.J.) (2023)“…Isolation of a protein/complex is important for its biochemical and structural characterization with mechanistic insights. TAP (tandem affinity purification)…”
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Novel Gene Regulatory Mechanisms with Implications in Cancer
Published 01-01-2022“…Eukaryotic gene expression to proteins is a complex process that begins with transcription which is regulated by numerous regulatory factors and signals…”
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Dissertation -
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Distinct Functions of the Cap-Binding Complex in Stimulation of Nuclear mRNA Export
Published in Molecular and cellular biology (01-04-2019)“…Cap-binding complex (CBC) associates cotranscriptionally with the cap structure at the 5′ end of nascent mRNA to protect it from exonucleolytic degradation…”
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An mRNA Capping Enzyme Targets FACT to the Active Gene To Enhance the Engagement of RNA Polymerase II into Transcriptional Elongation
Published in Molecular and cellular biology (01-07-2017)“…We have recently demonstrated that an mRNA capping enzyme, Cet1, impairs promoter-proximal accumulation/pausing of RNA polymerase II (Pol II) independently of…”
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An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function
Published in Molecular and cellular biology (16-03-2020)“…Although an F-box protein, Mdm30, is found to regulate ubiquitylation of the Sub2 component of TREX ( tr anscription- ex port) complex for proteasomal…”
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Two Distinct Regulatory Mechanisms of Transcriptional Initiation in Response to Nutrient Signaling
Published in Genetics (Austin) (01-01-2018)“…SAGA (Spt-Ada-Gcn5-Acetyltransferase) and TFIID (transcription factor IID) have been previously shown to facilitate the formation of the PIC (pre-initiation…”
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Genome-Wide Regulations of the Preinitiation Complex Formation and Elongating RNA Polymerase II by an E3 Ubiquitin Ligase, San1
Published in Molecular and cellular biology (20-01-2022)“…San1 ubiquitin ligase is involved in nuclear protein quality control via its interaction with intrinsically disordered proteins for ubiquitylation and…”
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Fine‐tuning of FACT by the ubiquitin proteasome system in regulation of transcriptional elongation
Published in The FASEB journal (01-04-2017)“…Abstract only FACT ( f acilitates c hromatin t ranscription), an evolutionarily conserved histone chaperone involved in transcription and other DNA…”
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Two Distinct Regulatory Mechanisms of Transcriptional Initiation in Response to Nutrient Signaling
Published in The FASEB journal (01-04-2019)“…SAGA (Spt‐Ada‐Gcn5‐Acetyltransferase) and TFIID (transcription factor IID) promote the formation of the PIC (pre‐initiation complex) at the promoters of two…”
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Journal Article -
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Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription
Published in Molecular and cellular biology (01-04-2021)“…FACT ( fa cilitates c hromatin t ranscription), an essential and evolutionarily conserved heterodimer from yeast to humans, controls transcription and is found…”
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Regulation of an Evolutionarily Conserved RNA Polymerase II‐Associated Factor 1 (Paf1) Involved in Pancreatic Oncogenesis
Published in The FASEB journal (01-04-2018)“…The multifunctional RNA polymerase II‐associated factor (Paf1) is highly conserved from yeast to humans and plays an important role in regulation of…”
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Fine‐Tuning of an Evolutionarily Conserved Histone Chaperone, FACT, by Ubiquitin‐Proteasome System, and its Targeting to the Active Gene by mRNA Capping Machinery to Regulate Transcriptional Elongation
Published in The FASEB journal (01-04-2018)“…Facilitates Chromatin Transcription (FACT), an evolutionarily conserved histone chaperone involved in multiple cellular processes, is upregulated in cancers,…”
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Regulation of Antisense Transcription by NuA4 Histone Acetyltransferase and Other Chromatin Regulatory Factors
Published in Molecular and cellular biology (01-03-2016)“…NuA4 histone lysine (K) acetyltransferase (KAT) promotes transcriptional initiation of TATA-binding protein (TBP)-associated factor (TAF)-dependent ribosomal…”
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Correction for Sen et al., "Fine-Tuning of FACT by the Ubiquitin Proteasome System in Regulation of Transcriptional Elongation"
Published in Molecular and cellular biology (15-07-2017)Get full text
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Ubiquitin–Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis
Published in Biochemistry (Easton) (21-11-2017)“…The evolutionarily conserved RNA polymerase II-associated factor 1 (Paf1) from yeast to humans regulates transcription and associated processes, and thus,…”
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