Search Results - "Kaiser, Stephen E"

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate by Crosignani, Stefano, Bingham, Patrick, Bottemanne, Pauline, Cannelle, Hélène, Cauwenberghs, Sandra, Cordonnier, Marie, Dalvie, Deepak, Deroose, Frederik, Feng, Jun Li, Gomes, Bruno, Greasley, Samantha, Kaiser, Stephen E, Kraus, Manfred, Négrerie, Michel, Maegley, Karen, Miller, Nichol, Murray, Brion W, Schneider, Manfred, Soloweij, James, Stewart, Albert E, Tumang, Joseph, Torti, Vince R, Van Den Eynde, Benoit, Wythes, Martin

“…Tumors use tryptophan-catabolizing enzymes such as indoleamine 2,3-dioxygenase (IDO-1) to induce an immunosuppressive environment. IDO-1 is induced in response…”
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The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins by Higgins, Reneé, Gendron, Joshua M., Rising, Lisa, Mak, Raymond, Webb, Kristofor, Kaiser, Stephen E., Zuzow, Nathan, Riviere, Paul, Yang, Bing, Fenech, Emma, Tang, Xin, Lindsay, Scott A., Christianson, John C., Hampton, Randolph Y., Wasserman, Steven A., Bennett, Eric J.

“…Insults to ER homeostasis activate the unfolded protein response (UPR), which elevates protein folding and degradation capacity and attenuates protein…”
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Atg8 Transfer from Atg7 to Atg3: A Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway by Taherbhoy, Asad M., Tait, Stephen W., Kaiser, Stephen E., Williams, Allison H., Deng, Alan, Nourse, Amanda, Hammel, Michal, Kurinov, Igor, Rock, Charles O., Green, Douglas R., Schulman, Brenda A.

“…Atg7 is a noncanonical, homodimeric E1 enzyme that interacts with the noncanonical E2 enzyme, Atg3, to mediate conjugation of the ubiquitin-like protein (UBL)…”
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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease by Hipp, Mark S, Patel, Chetan N, Bersuker, Kirill, Riley, Brigit E, Kaiser, Stephen E, Shaler, Thomas A, Brandeis, Michael, Kopito, Ron R

“…Pathognomonic accumulation of ubiquitin (Ub) conjugates in human neurodegenerative diseases, such as Huntington's disease, suggests that highly aggregated…”
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Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex by Sato, Yusuke, Fujita, Hiroaki, Yoshikawa, Azusa, Yamashita, Masami, Yamagata, Atsushi, Kaiser, Stephen E, Iwai, Kazuhiro, Fukai, Shuya

“…The linear ubiquitin chain assembly complex (LUBAC) is a key nuclear factor-κB (NF-κB) pathway component that produces linear polyubiquitin chains. The HOIL-1L…”
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Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures by Kaiser, Stephen E, Mao, Kai, Taherbhoy, Asad M, Yu, Shanshan, Olszewski, Jennifer L, Duda, David M, Kurinov, Igor, Deng, Alan, Fenn, Timothy D, Klionsky, Daniel J, Schulman, Brenda A

“…An early step in the autophagy process is the conjugation of the ubiquitin-like proteins (UBLs) Atg8 and Atg12 to their targets. Structural and functional…”
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Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection by Riley, Brigit E, Kaiser, Stephen E, Shaler, Thomas A, Ng, Aylwin C.Y, Hara, Taichi, Hipp, Mark S, Lage, Kasper, Xavier, Ramnik J, Ryu, Kwon-Yul, Taguchi, Keiko, Yamamoto, Masayuki, Tanaka, Keiji, Mizushima, Noboru, Komatsu, Masaaki, Kopito, Ron R

“…Genetic ablation of autophagy in mice leads to liver and brain degeneration accompanied by the appearance of ubiquitin (Ub) inclusions, which has been…”
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ALIX Is a Lys63-Specific Polyubiquitin Binding Protein that Functions in Retrovirus Budding by Dowlatshahi, Dara P., Sandrin, Virginie, Vivona, Sandro, Shaler, Thomas A., Kaiser, Stephen E., Melandri, Francesco, Sundquist, Wesley I., Kopito, Ron R.

“…The diversity of ubiquitin (Ub)-dependent signaling is attributed to the ability of this small protein to form different types of covalently linked polyUb…”
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Structural Basis of FFAT Motif-Mediated ER Targeting by Kaiser, Stephen E., Brickner, Jason H., Reilein, Amy R., Fenn, Tim D., Walter, Peter, Brunger, Axel T.

“…The FFAT motif is a targeting signal responsible for localizing a number of proteins to the cytosolic surface of the endoplasmic reticulum (ER) and to the…”
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Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3 by Qiu, Yu, Hofmann, Kay, Coats, Julie E., Schulman, Brenda A., Kaiser, Stephen E.

“…Ubiquitin‐like proteins (UBLs) are activated, transferred and conjugated by E1‐E2‐E3 enzyme cascades. E2 enzymes for canonical UBLs such as ubiquitin, SUMO,…”
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The Structure of the Yeast Plasma Membrane SNARE Complex Reveals Destabilizing Water-filled Cavities by Strop, Pavel, Kaiser, Stephen E., Vrljic, Marija, Brunger, Axel T.

“…SNARE proteins form a complex that leads to membrane fusion between vesicles, organelles, and plasma membrane in all eukaryotic cells. We report the 1.7Å…”
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Autophagy inhibition engages Nrf2-p62 Ub-associated signaling by Riley, Brigit E., Kaiser, Stephen E., Kopito, Ron R.

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Trans mechanism for ubiquitin-like protein transfer in autophagy by Taherbhoy, Asad M., Kaiser, Stephen E., Schulman, Brenda A.

“…Comment on: Taherbhoy AM, et al. Mol Cell 2011; 44:451-61…”
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Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A by Quinlan, Casey L, Kaiser, Stephen E, Bolaños, Ben, Nowlin, Dawn, Grantner, Rita, Karlicek-Bryant, Shannon, Feng, Jun Li, Jenkinson, Stephen, Freeman-Cook, Kevin, Dann, Stephen G, Wang, Xiaoli, Wells, Peter A, Fantin, Valeria R, Stewart, Al E, Grant, Stephan K

“…PF-9366 inhibits Mat2A by binding to an allosteric site that overlaps with the binding site of Mat2B, altering the active site and supporting a model in which…”
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Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools by Kaiser, Stephen E, Riley, Brigit E, Shaler, Thomas A, Trevino, R Sean, Becker, Christopher H, Schulman, Howard, Kopito, Ron R

“…Ubiquitin, an important post-translational modification that regulates a variety of biological processes is found in free and conjugated (monoubiquitin and…”
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Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis by Fadeyi, Olugbeminiyi, Parikh, Mihir D., Chen, Ming Z., Kyne Jr, Robert E., Taylor, Alexandria P., O'Doherty, Inish, Kaiser, Stephen E., Barbas, Sabrina, Niessen, Sherry, Shi, Manli, Weinrich, Scott L., Kath, John C., Jones, Lyn H., Robinson, Ralph P.

“…Sulfonyl fluoride (SF)‐based activity probes have become important tools in chemical biology. Herein, exploiting the relative chemical stability of SF to carry…”
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Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1 by Kaiser, Stephen E., Qiu, Yu, Coats, Julie E., Mao, Kai, Klionsky, Daniel J, Schulman, Brenda A.

“…Central to most forms of autophagy are two ubiquitin-like proteins (UBLs), Atg8 and Atg12, which play important roles in autophagosome biogenesis, substrate…”
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Ubiquitin-like modifiers by Taherbhoy, Asad M, Schulman, Brenda A, Kaiser, Stephen E

“…UBLs (ubiquitin-like proteins) are a major class of eukaryotic post-translational modifiers. UBLs are attached to numerous cellular proteins and to other…”
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Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins by Dalal, Seema, Canet, Denis, Kaiser, Stephen E., Dobson, Christopher M., Regan, Lynne

“…The amino acid sequence of a protein determines both its final folded structure and the folding mechanism by which this structure is attained. The differences…”
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Crystallographic Characterization of ATG Proteins and Their Interacting Partners by Qiu, Y, Zheng, Y, Taherbhoy, A M, Kaiser, S E, Schulman, B A

“…Autophagosome formation and specific substrate recruitment during autophagy require ligation of the ubiquitin-like protein (UBL) Atg8 to the head group of the…”
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