Search Results - "Kaiser, Fabian"

Collective cancer invasion forms an integrin-dependent radioresistant niche by Haeger, Anna, Alexander, Stephanie, Vullings, Manon, Kaiser, Fabian M P, Veelken, Cornelia, Flucke, Uta, Koehl, Gudrun E, Hirschberg, Markus, Flentje, Michael, Hoffman, Robert M, Geissler, Edward K, Kissler, Stephan, Friedl, Peter

“…Cancer fatalities result from metastatic dissemination and therapy resistance, both processes that depend on signals from the tumor microenvironment. To…”
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IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion by Kaiser, Fabian M. P., Janowska, Iga, Menafra, Roberta, de Gier, Melanie, Korzhenevich, Jakov, Pico-Knijnenburg, Ingrid, Khatri, Indu, Schulz, Ansgar, Kuijpers, Taco W., Lankester, Arjan C., Konstantinidis, Lukas, Erlacher, Miriam, Kloet, Susan, van Schouwenburg, Pauline A., Rizzi, Marta, van der Burg, Mirjam

“…•IL-7 induces a strong proliferative burst in early human B-cell progenitors but has a limited role in the prevention of cell death.•IL-7 enhances BACH2, EBF1,…”
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IL-17 silencing does not protect nonobese diabetic mice from autoimmune diabetes by Joseph, Julie, Bittner, Stefan, Kaiser, Fabian M P, Wiendl, Heinz, Kissler, Stephan

“…The long-held view that many autoimmune disorders are primarily driven by a Th1 response has been challenged by the discovery of Th17 cells. Since the…”
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Protein functionality as a potential bottleneck for somatic revertant variants by Kaiser, Fabian M.P., Reisli, Ismail, Pico-Knijnenburg, Ingrid, Langerak, Anton W., Kavelaars, François G., Artac, Hasibe, IJspeert, Hanna, van der Burg, Mirjam

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Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder by Kaiser, Fabian M P, Gruenbacher, Sarah, Oyaga, Maria Roa, Nio, Enzo, Jaritz, Markus, Sun, Qiong, van der Zwaag, Wietske, Kreidl, Emanuel, Zopf, Lydia M, Dalm, Virgil A S H, Pel, Johan, Gaiser, Carolin, van der Vliet, Rick, Wahl, Lucas, Rietman, André, Hill, Louisa, Leca, Ines, Driessen, Gertjan, Laffeber, Charlie, Brooks, Alice, Katsikis, Peter D, Lebbink, Joyce H G, Tachibana, Kikuë, van der Burg, Mirjam, De Zeeuw, Chris I, Badura, Aleksandra, Busslinger, Meinrad

“…The genetic causes of primary antibody deficiencies and autism spectrum disorder (ASD) are largely unknown. Here, we report a patient with…”
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Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency by van Schouwenburg, Pauline, Unger, Susanne, Payne, Kathryn J., Kaiser, Fabian M. P., Pico-Knijnenburg, Ingrid, Pfeiffer, Jens, Hausmann, Oliver, Friedmann, David, Erbel, Michelle, Seidl, Maximilian, van Zessen, David, Stubbs, Andrew P., van der Burg, Mirjam, Warnatz, Klaus

“…Common variable immunodeficiency (CVID), characterized by recurrent infections, low serum class-switched immunoglobulin isotypes, and poor antigen-specific…”
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Modelling of Static and Dynamic Elastomer Friction in Dry Conditions by Kaiser, Fabian, Savio, Daniele, Bactavatchalou, Ravindrakumar

“…Understanding the tribological behavior of elastomers in dry conditions is essential for sealing applications, as dry contact may occur even in lubricated…”
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Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing by Humbert, Michael, Rasmussen, Robert A, Ong, Helena, Kaiser, Fabian M P, Hu, Shiu-Lok, Ruprecht, Ruth M

“…Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and…”
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Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium by Hansen, Jan N, Kaiser, Fabian, Klausen, Christina, Stüven, Birthe, Chong, Raymond, Bönigk, Wolfgang, Mick, David U, Möglich, Andreas, Jurisch-Yaksi, Nathalie, Schmidt, Florian I, Wachten, Dagmar

“…Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that…”
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Correction: Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder by Kaiser, Fabian M P, Gruenbacher, Sarah, Oyaga, Maria Roa, Nio, Enzo, Jaritz, Markus, Sun, Qiong, van der Zwaag, Wietske, Kreidl, Emanuel, Zopf, Lydia M, Dalm, Virgil A S H, Pel, Johan, Gaiser, Carolin, van der Vliet, Rick, Wahl, Lucas, Rietman, André, Hill, Louisa, Leca, Ines, Driessen, Gertjan, Laffeber, Charlie, Brooks, Alice, Katsikis, Peter D, Lebbink, Joyce H G, Tachibana, Kikuë, van der Burg, Mirjam, De Zeeuw, Chris I, Badura, Aleksandra, Busslinger, Meinrad

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Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial by Antonakakis, Marios, Kaiser, Fabian, Rampp, Stefan, Kovac, Stjepana, Wiendl, Heinz, Stummer, Walter, Gross, Joachim, Kellinghaus, Christoph, Khaleghi-Ghadiri, Maryam, Möddel, Gabriel, Wolters, Carsten H.

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Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model by Serra, Ines, Manusama, Olivia R., Kaiser, Fabian M.P., Floriano, Izi Izumi, Wahl, Lucas, van der Zalm, Christian, IJspeert, Hanna, van Hagen, P. Martin, van Beveren, Nico J.M., Arend, Sandra M., Okkenhaug, Klaus, Pel, Johan J.M., Dalm, Virgil A.S.H., Badura, Aleksandra

“…The phosphoinositide-3-kinase (PI3K) family plays a major role in cell signaling and is predominant in leukocytes. Gain-of-function (GOF) mutations in the…”
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Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome by Bauer, Michael, Kölsch, Uwe, Krüger, Renate, Unterwalder, Nadine, Hameister, Karin, Kaiser, Fabian Marc, Vignoli, Aglaia, Rossi, Rainer, Botella, Maria Pilar, Budisteanu, Magdalena, Rosello, Monica, Orellana, Carmen, Tejada, Maria Isabel, Papuc, Sorina Mihaela, Patat, Oliver, Julia, Sophie, Touraine, Renaud, Gomes, Thusari, Wenner, Kirsten, Xu, Xiu, Afenjar, Alexandra, Toutain, Annick, Philip, Nicole, Jezela-Stanek, Aleksandra, Gortner, Ludwig, Martinez, Francisco, Echenne, Bernard, Wahn, Volker, Meisel, Christian, Wieczorek, Dagmar, El-Chehadeh, Salima, Van Esch, Hilde, von Bernuth, Horst

“…MECP2 (methyl CpG binding protein 2) duplication causes syndromic intellectual disability. Patients often suffer from life-threatening infections, suggesting…”
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Sphingolipids controlling ciliary and microvillar function by Kaiser, Fabian, Huebecker, Mylene, Wachten, Dagmar

“…Cilia and microvilli are membrane protrusions that extend from the surface of many different mammalian cell types. Motile cilia or flagella are only found on…”
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A Study on the Friction Reduction of Seal Ring for Automatic Transmission by Applying Surface Texture by Watanabe, Koji, Seki, Kazunari, Tadano, Hikaru, Kaiser, Fabian

“…Texturing on sliding surface of resin seal ring was attempted to improve lubrication in this study. Numerical analysis of hydrodynamic flow at the sliding…”
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The TH1 phenotype of follicular helper T cells indicates an IFN-γ–associated immune dysregulation in patients with CD21low common variable immunodeficiency by Unger, Susanne, Seidl, Maximilian, van Schouwenburg, Pauline, Rakhmanov, Mirzokhid, Bulashevska, Alla, Frede, Natalie, Grimbacher, Bodo, Pfeiffer, Jens, Schrenk, Klaudia, Munoz, Luis, Hanitsch, Leif, Stumpf, Ina, Kaiser, Fabian, Hausmann, Oliver, Kollert, Florian, Goldacker, Sigune, van der Burg, Mirjam, Keller, Baerbel, Warnatz, Klaus

“…A subgroup of patients with common variable immunodeficiency (CVID) experience immune dysregulation manifesting as autoimmunity, lymphoproliferation, and organ…”
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Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors by Klausen, Christina, Kaiser, Fabian, Stüven, Birthe, Hansen, Jan N, Wachten, Dagmar

“…The second messenger 3',5'-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic…”
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A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation by Hansen, Jan N, Kaiser, Fabian, Leyendecker, Philipp, Stüven, Birthe, Krause, Jens‐Henning, Derakhshandeh, Fatemeh, Irfan, Jaazba, Sroka, Tommy J, Preval, Kenley M, Desai, Paurav B, Kraut, Michael, Theis, Heidi, Drews, Anna‐Dorothee, De‐Domenico, Elena, Händler, Kristian, Pazour, Gregory J, Henderson, David J P, Mick, David U, Wachten, Dagmar

“…The primary cilium constitutes an organelle that orchestrates signal transduction independently from the cell body. Dysregulation of this intricate molecular…”
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A patient-based murine model recapitulates human STAT3 gain-of-function syndrome by Meesilpavikkai, Kornvalee, Zhou, Zijun, Kaikaew, Kasiphak, Phakham, Suphattra, van der Spek, Peter J., Swagemakers, Sigrid, Venter, Deon J., de Bie, Maaike, Schrijver, Benjamin, Schliehe, Christopher, Kaiser, Fabian, Dalm, Virgil A.S.H., van Hagen, P. Martin, Hirankarn, Nattiya, IJspeert, Hanna, Dik, Willem A.

“…STAT3 gain-of-function (GOF) variants results in a heterogeneous clinical syndrome characterized by early onset immunodeficiency, multi-organ autoimmunity, and…”
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Longitudinal ultrasonic vibration assisted guillotining of stacked paper by Deibel, Karl-Robert, Kaiser, Fabian, Zimmermann, Remo, Meier, Linus, Bolt, Peter, Wegener, Konrad

“…•A dynamic model for longitudinal vibration assisted guillotining of paper is developed.•Empirical model of a stack of thin paper material is identified.•Novel…”
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