Search Results - "Kaiser, Alyssa"

Deconstructing networks of p53-mediated tumor suppression in vivo by Kaiser, Alyssa M, Attardi, Laura D

“…The transcription factor p53 is a vital tumor suppressor. Upon activation by diverse stresses including oncogene activation, DNA damage, hypoxia and nutrient…”
Get full text

Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program by Bieging-Rolett, Kathryn T., Kaiser, Alyssa M., Morgens, David W., Boutelle, Anthony M., Seoane, Jose A., Van Nostrand, Eric L., Zhu, Changyu, Houlihan, Shauna L., Mello, Stephano S., Yee, Brian A., McClendon, Jacob, Pierce, Sarah E., Winters, Ian P., Wang, Mengxiong, Connolly, Andrew J., Lowe, Scott W., Curtis, Christina, Yeo, Gene W., Winslow, Monte M., Bassik, Michael C., Attardi, Laura D.

“…Although TP53 is the most commonly mutated gene in human cancers, the p53-dependent transcriptional programs mediating tumor suppression remain incompletely…”
Get full text

Intestinal calcium and bile salts facilitate germination of Clostridium difficile spores by Kochan, Travis J, Somers, Madeline J, Kaiser, Alyssa M, Shoshiev, Michelle S, Hagan, Ada K, Hastie, Jessica L, Giordano, Nicole P, Smith, Ashley D, Schubert, Alyxandria M, Carlson, Jr, Paul E, Hanna, Philip C

“…Clostridium difficile (C. difficile) is an anaerobic gram-positive pathogen that is the leading cause of nosocomial bacterial infection globally. C. difficile…”
Get full text

The Mettl3 epitranscriptomic writer amplifies p53 stress responses by Raj, Nitin, Wang, Mengxiong, Seoane, Jose A, Zhao, Richard L, Kaiser, Alyssa M, Moonie, Nancie A, Demeter, Janos, Boutelle, Anthony M, Kerr, Craig H, Mulligan, Abigail S, Moffatt, Clare, Zeng, Shelya X, Lu, Hua, Barna, Maria, Curtis, Christina, Chang, Howard Y, Jackson, Peter K, Attardi, Laura D

“…The p53 transcription factor drives anti-proliferative gene expression programs in response to diverse stressors, including DNA damage and oncogenic signaling…”
Get full text

p53 governs an AT1 differentiation programme in lung cancer suppression by Kaiser, Alyssa M., Gatto, Alberto, Hanson, Kathryn J., Zhao, Richard L., Raj, Nitin, Ozawa, Michael G., Seoane, José A., Bieging-Rolett, Kathryn T., Wang, Mengxiong, Li, Irene, Trope, Winston L., Liou, Douglas Z., Shrager, Joseph B., Plevritis, Sylvia K., Newman, Aaron M., Van Rechem, Capucine, Attardi, Laura D.

“…Lung cancer is the leading cause of cancer deaths worldwide 1 . Mutations in the tumour suppressor gene TP53 occur in 50% of lung adenocarcinomas (LUADs) and…”
Get full text

Variation in germination of Clostridium difficile clinical isolates correlates to disease severity by Carlson, Paul E., Kaiser, Alyssa M., McColm, Sarah A., Bauer, Jessica M., Young, Vincent B., Aronoff, David M., Hanna, Philip C.

“…Over the past two decades, Clostridium difficile infections have been increasing in both number and severity throughout the world. As with other spore forming…”
Get full text

Tissue-regeneration program underlies lung-cancer suppression

Get full text

A p53 Super Tumor Suppressor Reveals Fundamental Roles of p53 in Lung Cancer and Regeneration by Kaiser, Alyssa Marie

“…p53 is critical for tumor suppression. This is evidenced by (1) the fact that the TP53 gene is the most frequently mutated gene in human cancer, (2) patients…”
Get full text

Abstract 3403: Leveraging a p53 “super-tumor suppressor” to understand mechanisms of lung adenocarcinoma regression by Wang, Mengxiong, Kaiser, Alyssa, Bieging-Rolett, Kathryn, Brady, Colleen, Attardi, Laura

“…Lung cancer is the leading cause of cancer deaths worldwide, and lung adenocarcinoma (LUAD) comprises the majority of lung cancer cases. Inactivation of the…”
Get full text

Abstract IA07: Deconstructing p53 pathways in tumor suppression by Mello, Stephano Spano, Bieging-Rolett, Kathryn, Kaiser, Alyssa, Valente, Elizabeth Joy, Raj, Nitin, McClendon, Jacob, Flowers, Brittany Maria, Morgens, David Warren, Bassik, Michael Cory, Attardi, Laura Donatella

“…The p53 transcription factor is a critical tumor suppressor in humans and mice. Despite this essential function, the molecular pathways through which p53 acts…”
Get full text

Abstract C056: The initiation and progression of pancreatic ductal adenocarcinoma through a p53 lens by Hanson, Kathryn J., Minor, Allegra C., Flowers, Brittany M., Kaiser, Alyssa M., Hughes, Nicholas, Vogel, Hannes, Cong, Le, Attardi, Laura D.

“…Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of only 11%. Slated to be the 2nd most deadly cancer by 2026,…”
Get full text