Search Results - "Kaiser, Alaina"
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Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response
Published in Journal for immunotherapy of cancer (21-11-2017)“…It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency…”
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Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using d -Alanine Auxotrophy
Published in mSphere (10-06-2020)“…The skin microbiome is rich in opportunities for novel therapeutics for skin diseases, and synthetic biology offers the advantage of providing novel…”
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CD8+ T-cell mediated anti-malaria protection induced by malaria vaccines; assessment of hepatic CD8+ T cells by SCBC assay
Published in Human vaccines & immunotherapeutics (03-07-2017)“…Malaria is a severe infectious disease with relatively high mortality, thus having been a scourge of humanity. There are a few candidate malaria vaccines that…”
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Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL
Published in Blood (23-08-2018)“…After treatment with chimeric antigen receptor (CAR) T cells, interleukin-15 (IL-15) elevation and CAR T-cell expansion are associated with non-Hodgkin…”
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Proteogenomic detection of circulating biomarkers for clinical oncology
Published in Journal of clinical oncology (01-06-2022)“…e15010 Background: Circulating biomarkers have the potential to detect cancer in its earliest stages and monitor patients in remission. The integration of…”
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Abstract 19: Proteome-wide biomarker discovery using digital MosaicNeedles
Published in Cancer research (Chicago, Ill.) (01-07-2021)“…Abstract Changes in transcript levels detected by transcriptome profiling have been widely used as a surrogate for proteomics. However, recent studies have…”
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MosaicNeedles: A tool for multi-omic liquid biopsy sensitivity and specificity enhancement
Published in Journal of clinical oncology (20-05-2021)“…Abstract only e15019 Background: Liquid biopsy has evolved to be an important method complementary to tissue biopsy. It is not only non-invasive, but also has…”
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Abstract 3919: MosaicNeedles: A tool for large-scale proteomics combining antibodies and aptamers
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Proteomics have the potential to transform biomarker discovery, diagnostics, and personalized medicine as it provides functional and actionable…”
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Abstract 2990: Polyfunctional anti-CD19 CAR T cells determined by single-cell multiplex proteomics associated with clinical activity in patients with advanced non-Hodgkin’s lymphoma
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Abstract Introduction: Autologous anti-CD19 CAR T cells have shown promising clinical efficacy in B cell malignancies, with T cell expansion and blood levels…”
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