Search Results - "Kaisar, Mohammad A"

New experimental models of the blood-brain barrier for CNS drug discovery by Kaisar, Mohammad A, Sajja, Ravi K, Prasad, Shikha, Abhyankar, Vinay V, Liles, Taylor, Cucullo, Luca

“…The blood-brain barrier (BBB) is a dynamic biological interface which actively controls the passage of substances between the blood and the central nervous…”
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Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure? by Kaisar, Mohammad A., Villalba, Heidi, Prasad, Shikha, Liles, Taylor, Sifat, Ali Ehsan, Sajja, Ravi K., Abbruscato, Thomas J., Cucullo, Luca

“…Recently published in vitro and in vivo findings strongly suggest that BBB impairment and increased risk for stroke by tobacco smoke (TS) closely resemble that…”
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A convenient UHPLC-MS/MS method for routine monitoring of plasma and brain levels of nicotine and cotinine as a tool to validate newly developed preclinical smoking model in mouse by Kaisar, Mohammad A, Kallem, Raja Reddy, Sajja, Ravi K, Sifat, Ali Ehsan, Cucullo, Luca

“…A sensitive, rapid and selective UHPLC-MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using…”
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Conventional and electronic cigarettes dysregulate the expression of iron transporters and detoxifying enzymes at the brain vascular endothelium: In vivo evidence of a gender-specific cellular response to chronic cigarette smoke exposure by Kaisar, Mohammad A., Sivandzade, Farzane, Bhalerao, Aditya, Cucullo, Luca

“…•TS and e-Cig vapor similarly disrupt mitochondrial membrane potential in brain vascular endothelial cells.•The expression levels of Slc40a1 and Abcb6 are…”
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Nicotine and electronic cigarette (E‐Cig) exposure decreases brain glucose utilization in ischemic stroke by Sifat, Ali E., Vaidya, Bhuvaneshwar, Kaisar, Mohammad A., Cucullo, Luca, Abbruscato, Thomas J.

“…Previous studies in our laboratory have shown that nicotine exposure decreases glucose transport across the blood–brain barrier in ischemia‐reperfusion…”
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Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10? by Sajja, Ravi K., Prasad, Shikha, Tang, Suni, Kaisar, Mohammad A., Cucullo, Luca

“…•In vivo fluorescence imaging revealed BBB hyper-permeability in diabetic mice.•Nrf2 is significantly down-regulated in diabetic brain.•Nrf2 regulates…”
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In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity by Sajja, Ravi K., Kaisar, Mohammad A., Vijay, Vikrant, Desai, Varsha G., Prasad, Shikha, Cucullo, Luca

“…Sulforaphane (SFN) has been shown to protect the brain vascular system and effectively reduce ischemic injuries and cognitive deficits. Given the robust…”
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Hyperglycemia exacerbates antiretroviral drug combination induced blood-brain barrier endothelial toxicity by Prasad, Shikha, Sajja, Ravi K., Kaisar, Mohammad A., Cucullo, Luca

“…In this study, we sought to investigate how concomitant hyperglycemia influences the impact of combination antiretroviral therapy on blood-brain barrier (BBB)…”
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Chemical and biological investigations of Delonix regia (Bojer ex Hook.) Raf by Jahan, Israt, Rahman, Mohammad, Rahman, Mohammed, Kaisar, Mohammad, Islam, Mohammad, Wahab, Abdul, Rashid, Mohammad

“…In this study, five compounds, lupeol (1), epilupeol (2), β-sitosterol (3), stigmasterol (4) and p-methoxybenzaldehyde (5) were isolated from the petroleum…”
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Kemijsko i biološko ispitivanje biljke Delonix regia (Bojer ex Hook.) Raf by Jahan, Israt, Rahman, Mohammad S, Rahman, Mohammed Z, Kaisar, Mohammad A, Islam, Mohammad S, Wahab, Abdul, Rashid, Mohammad A

“…U radu je opisana izolacija pet sastojaka petroleterske i diklormetanske frakcije metanolnog ekstrakta kore biljke Delonix regia: lupeol (1), epilupeol (2),…”
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