Search Results - "Kainov, Yaroslav"

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells by Kainov, Yaroslav A., Makeyev, Eugene V.

“…Eukaryotic gene expression relies on extensive crosstalk between transcription and RNA processing. Changes in this composite regulation network may provide an…”
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PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells by Iannone, Camilla, Kainov, Yaroslav, Zhuravskaya, Anna, Hamid, Fursham, Nojima, Takayuki, Makeyev, Eugene V.

“…Many spliceosomal introns are excised from nascent transcripts emerging from RNA polymerase II (RNA Pol II). The extent of cell-type-specific regulation and…”
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An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion by Collins, Katherine M, Kainov, Yaroslav A, Christodolou, Evangelos, Ray, Debashish, Morris, Quaid, Hughes, Timothy, Taylor, Ian A, Makeyev, Eugene V, Ramos, Andres

“…RBM10 is an RNA-binding protein that plays an essential role in development and is frequently mutated in the context of human disease. RBM10 recognizes a…”
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Protocol for auxin-inducible depletion of the RNA-binding protein PTBP1 in mouse embryonic stem cells by Kainov, Yaroslav, Zhuravskaya, Anna, Makeyev, Eugene V.

“…Inducible degradation of proteins of interest provides a powerful approach for functional studies. Here, we present a protocol for tightly controlled depletion…”
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Conserved Noncanonical Residue Gly-126 Confers Instability to the Middle Part of the Tropomyosin Molecule by Nevzorov, Ilya A., Nikolaeva, Olga P., Kainov, Yaroslav A., Redwood, Charles S., Levitsky, Dmitrii I.

“…Tropomyosin (Tm) is a two-stranded α-helical coiled-coil protein with a well established role in regulation of actin cytoskeleton and muscle contraction. It is…”
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Complex Selection on Human Polyadenylation Signals Revealed by Polymorphism and Divergence Data by Kainov, Yaroslav A, Aushev, Vasily N, Naumenko, Sergey A, Tchevkina, Elena M, Bazykin, Georgii A

“…Polyadenylation is a step of mRNA processing which is crucial for its expression and stability. The major polyadenylation signal (PAS) represents a nucleotide…”
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Expression and clinical significance of CRABP1 and CRABP2 in non-small cell lung cancer by Favorskaya, Irina, Kainov, Yaroslav, Chemeris, Galina, Komelkov, Andrei, Zborovskaya, Irina, Tchevkina, Elena

“…The impairment of retinoic acid (RA)-dependent signaling is a frequent event during carcinogenesis. Cellular retinoic acid-binding proteins (CRABP1 and CRABP2)…”
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CRABP1 provides high malignancy of transformed mesenchymal cells and contributes to the pathogenesis of mesenchymal and neuroendocrine tumors by Kainov, Yaroslav, Favorskaya, Irina, Delektorskaya, Vera, Chemeris, Galina, Komelkov, Andrei, Zhuravskaya, Anna, Trukhanova, Lyubov, Zueva, Elina, Tavitian, Bertrand, Dyakova, Natalya, Zborovskaya, Irina, Tchevkina, Elena

“…CRABP1 (cellular retinoic acid binding protein 1) belongs to the family of fatty acid binding proteins. Retinoic acid binding is the only known functional…”
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